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The field of organ transplantation is experiencing a transformative shift with the rise of Advanced Therapy Medicinal Products (ATMPs), which include gene therapies, somatic cell therapies, and tissue-engineered products. These therapies offer new, potentially curative treatments for longstanding medical challenges, impacting numerous patients. However, their adoption is hindered by complex regula
Liquid crystalline nanoparticles (LCNPs), e.g. cubosomes and hexosomes, are receiving more and more attraction as drug delivery vehicles. Dry powder formulation that forms LCNPs upon hydration can be advantageous to make new routes of administration accessible. In this work, we investigate use of three disaccharides (lactose, trehalose and sucrose) as protective matrices for glycerol monooleate ba
The coefficient of friction (COF) and wear are critical parameters in assessing disc brake performance. However, their study is challenging due to their interdependence on contact pressure, sliding velocity, temperature, and material composition. The complex contact interactions between brake pads and discs involve the continuous formation and destruction of mesoscopic contact plateaus, which
Software is at the core of digitalisation and is often claimed to play a central role in innovation and in shaping competition across industries and firms. There are yet few studies of the extent and nature of software development across firms. We employ a unique firm-level survey comprising 3,929 firms across Sweden to analyse the distribution and characteristics of firms that invest in software
In the present work, we describe the design, synthesis, and evaluation of a galectin-8- binding fluorescent probe designed for a competitive fluorescence polarization (FP) assay for screening new galectin-8N inhibitors. The probe was characterized for its photophysical properties and its binding affinity for galectin-8N was determined by using FP. We evaluated the probe in a competitive FP assay w
Iran has gone through a very rapid urbanization in the last six decades. The fast pace of urbanization of the country calls for an integrated planning to move towards sustainable urban development and resilient and livable cities. Despite five decades of history in preparation of urban plans and two decades of history since the introduction of urban management in Iran, the urban policymaking, in
This systematic literature review assesses the current state of knowledge on how increased ICT use affects individual time-use patterns and the associated implications for lifestyle climate implications. While the environmental impacts of ICT have been widely debated in terms of direct energy consumption, there has been limited focus on the indirect time-use effects. The review draws on 101 articl
Background: Physiotherapy is usually the first line of treatment for musculoskeletal disorders. If pain persists, an appointment with an orthopaedic surgeon is indicated, but many disorders for which patients are placed on orthopaedic waiting lists cannot be treated in an orthopaedic clinic. Specialised manual therapy, although not mainstream, can be an effective alternative to orthopaedic care, a
Task 3.1 in Work Package (WP) 3 of the CULTIVATE project aims to investigate costs, investments, challenges, drivers, and success factors to establish and maintain urban and peri-urban food sharing initiatives (FSIs). This investigation builds on the conceptual framework, which has been developed from a systematic literature review on the topic of food sharing and enriched with topics from several
Background: Older adults have complex medical needs that causes increased use of resources at the emergency department (ED). The prevalence of non-specific complaint (NSC) as a chief-complaint in the ED is common among older adults and is not prioritized even though possibly having worse clinical outcome. The objective was to study hospital admission and mortality for older adults visiting the ED
This paper describes the development of a fixed dose dry powder combination of indacaterol maleate (Inda) and glycopyrronium bromide (Glyco) in Easyhaler® inhaler for a comparative pharmacokinetic (PK) study, as well as the outcome of such a study. The development aim was to produce formulations with three different in vitro dispersibility profiles for both Inda and Glyco. This so-called ‘rake’ ap
Aims/hypothesis: The aim of this study was to determine whether BMI in early childhood was affected by the COVID-19 pandemic and containment measures, and whether it was associated with the risk for islet autoimmunity. Methods: Between February 2018 and May 2023, data on BMI and islet autoimmunity were collected from 1050 children enrolled in the Primary Oral Insulin Trial, aged from 4.0 months to
Purpose: The apparel and textile sector poses a significant environmental challenge due to its substantial contribution to pollution in the form of air, water and soil pollution. To combat these issues, the adoption of sustainable practices is essential. This study aims to identify and analyse the barriers that hinder the progress of sustainability in the apparel and textile industry. By consultin
Literature reviews lay the foundation for almost every academic research project, and sometimes are a scholarly contribution in its own right. To increase rigor and credibility the findings have to be valid and reliable just as in any other type of research. This paper summarizes recent methodological developments in the application systematic literature reviews in supply chain management. It anal
