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Insomnia and short and long sleep durations have all been linked to cardiovascular disease. Male gender and low socioeconomic status are also related to cardiovascular disease, but it is unclear whether these two factors modify the impact of poor sleep on cardiovascular disease incidence.
Background: Activated microglia with macrophage-like functions invade and surround beta-amyloid (A beta) plaques in Alzheimer's disease (AD), possibly contributing to the turnover of A beta, but they can also secrete proinflammatory factors that may be involved in the pathogenesis of AD. Microglia are known to modulate adult hippocampal neurogenesis. Objectives/Methods: To determine the role of mi
To evaluate drug adherence, clinical response and predictors thereof for tocilizumab in patients with RA in routine care based on prospectively collected data from the Swedish biologics register, Anti-Rheumatic Therapies in Sweden.
Exposure to inorganic arsenic has been identified as a risk factor for elevated blood pressure and cardiovascular disease. Our aim with this study was to elucidate effects of arsenic on blood pressure and early risk markers of cardiovascular disease in a population with efficient arsenic metabolism that can modify other arsenic-related health effects.
Yeast xylose metabolism is generally considered to be restricted to respirative conditions because the two-step oxidoreductase reactions from xylose to xylulose impose an anaerobic redox imbalance. We have recently developed, however, a Saccharomyces cerevisiae strain that is at present the only known yeast capable of anaerobic growth on xylose alone. Using transcriptome analysis of aerobic chemos
The four major autoantigens (IA-2, IA-2 beta, GAD65 and insulin) of type 1 diabetes are all associated with dense core or synaptic vesicles. This raised the possibility that other secretory vesicle-associated proteins might be targets of the autoimmune response in type 1 diabetes. To test this hypothesis 56 proteins, two-thirds of which are associated with secretory vesicles, were prepared by in v
Objective: Little is known about the etiology of small bowel carcinoid tumor (SBC), but a few studies have pointed to certain medical and lifestyle factors as potential risk factors. This study aims to evaluate these findings and to identify new associations. Methods: A population-based European multicenter case-control study was conducted from 1995 through 1997. Incident histologically verified 3
During recent years, the radial movement of the arterial wall has been extensively studied, and measurements of the radial movement are now an important tool in cardiovascular research for characterizing the mechanical properties of the arterial wall. In contrast, the longitudinal movement of vessels has gained little or no attention as it has been presumed that this movement is negligible. With m
Previous cytogenetic and comparative genomic hybridization (CGH) analyses have shown that the gain of chromosome arm 12p is frequent in pancreatic carcinomas. We investigated 15 pancreatic carcinoma cell lines using CGH, fluorescence in situ hybridization (FISH), and semiquantitative polymerase chain reaction (PCR) to characterize 12p amplifications in detail. The CGH analysis revealed gains of 12
In this study, a method was developed for determining the concentration of the pharmaceutical fluoxetine and its metabolite, norfluoxetine, in sewage water samples. Sample preparation was performed by hollow-fibre supported liquid membrane (HF-SLM) extraction with final analysis using liquid chromatography with UV detection. Several parameters were studied including type of organic solvent, sample
Larsson PG, Bergstrom M. Forsum U, Jacobsson B, Strand A, Wolner-Hanssen P Bacterial vaginosis. Transmission, role in genital tract infection and pregnancy outcome: an enigma. APMIS 2005; 113:233-45. Whether bacterial vaginosis (BV) is acquired from an endogenous or an exogenous source is subject to controversy Despite findings of an association between sexual behaviour and BV some data indicate t
To further develop and evaluate a pharmacophore model previously proposed by Cook and co-workers (Drug Des. Discovery 1995,12,193-248) for ligands binding to the benzodiazepine site of the GABA(A) receptor, 40 new flavone derivatives have been synthesized and their affinities for the benzodiazepine site have been determined. Two new regions of steric repulsive interactions between ligand and recep
Study purpose: The primary aim of this study is to explore the performance of different supply chain configurations made in response to various U.S. tariff rate conditions, particularly those impacting imports from China. Previous research has predominantly addressed this topic at the macro level, whereas this study employs a single-case firm, Nexus, to provide a more comprehensive analysis of the
Cash holding strategy is an important financial decision for firms. It is highly related to firms’ operation and development because cash is an important guarantee to meet the business payment and investment opportunity. However, some scholars believe that due to agency problems, too much cash holdings are likely to produce negative impact on enterprise value. Compared to listed firms on Chinese A
The aim of this master thesis is to provide an indication of the suitability, or otherwise usage, of spray-drying for production of powder aimed for inhalation formulation and comparing the characteristics of the product, with and without lipids. Lipids have a proven effect of delaying release of active drug substances in the cardiovascular system and pulmonary systemic delivery has a number of ad
Based on the imbalances caused by asymmetric information and opaque supply chains, this study aims to contribute to the research field of logistics and supply chain management by exploring the potential of blockchain technology within logistics. The main focus is on increasing supply chain transparency for both suppliers and consumers, and improving contractual coordination in order to secure fulf
This master thesis project was performed in collaboration with Johnson Matthey. Johnson Matthey is a worldwide company working with sustainable technologies. The site in Perstorp, where this work was performed, focus on formaldehyde production. In order to continuously improve chemical processes, simulation and modeling are advantageous tools. They can give a better understanding of the processes
This thesis poses structural and behavioural competition problems in digital markets in terms of core platforms services provided by the gatekeepers under the proposed Digital Markets Act by the European Commission, where such problems are the most evident. This thesis analyses whether existing competition and more sector-specific legal tools are functional to address these problems. Traditional l
