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We aim to identify novel interventions for prevention and treatment of diabetes-related cardiovascular disease (CVD). Our strategy is to identify genetic, endocrine and metabolic disturbances in humans which are causally related to disease development and are detectable many years before disease presents. We then test in both animals and in human intervention studies if manipulation of such molecu
Välkommen till Institutionen för hälsovetenskaper, en av sex institutioner vid Medicinska fakulteten, Lunds universitet. Genom vår forskning ökar vi kunskapen och förståelsen om människors hälsa och livskvalitet. Hälsofrämjande och förebyggande insatser, behandlande åtgärder, vård och omsorg och rehabilitering är centrala forskningsområden. Vi arbetar i nära samarbete med hälso- och sjukvård och kThe Department of Health Sciences is one of six departments at the Faculty of Medicine, Lund University. We conduct research within the field of health sciences. Health promotion and prevention efforts, Treatment measures, Health and social care and Rehabilitation are key research areas. We work in close collaboration with health care and municipalities to translate research results into practical
Hjärt-kärlsjukdom är världens vanligaste dödsorsak. Det främsta underliggande tillståndet är ateroskleros: plack som bildas i blodkärlens väggar och kan orsaka akuta komplikationer, såsom hjärtinfarkt och stroke. Genom vår forskning ämnar vi identifiera kliniska metoder som kan hjälpa oss att hitta plack med hög komplikationsrisk, för att i tid kunna ge adekvat förebyggande behandling. Vi vill äveCardiovascular disease is the most common cause of death. The main underlying condition is atherosclerosis: plaques formed in the arteries which can cause complications as stroke or myocardial infarction. Our research aims to prevent complications by identifying clinical methods to detect patients with high-risk plaques to personalize treatment strategies as well as novel mechanisms to use as ther
Existing metastatic disease represents a major clinical challenge. The long-term goal of our study is to gain deeper understanding of cellular mechanisms underlying cancer metastasis. We focus on identification and validation of new predictive biomarkers and drug targets that are specifically for metastatic cancer. We recently focus on studying the role of lipid kinases in particular, phosphatidyl
Cytokines play an important role in the regulation of homeostasis and inflammation. A de-regulated cytokine function can subsequently promote chronic inflammation. This is supported by clinical evidence showing the beneficial effect of inhibiting TNF-alpha through injection of antibodies and soluble receptor in disorders such as rheumatoid arthritis and Crohn's disease. Systemic anti-TNF-alpha the
BACKGROUND: Glioblastomas (GBM) are therapy-resistant tumors with a profoundly immunosuppressive tumor microenvironment. Chemotherapy has shown limited efficacy against GBM. Systemic delivery of chemotherapeutic drugs is hampered by the difficulty of achieving intratumoral levels as systemic toxicity is a dose-limiting factor. Although some of its effects might be mediated by immune reactivity, sy
