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Radiocarbon dating is the gold standard in archeology to estimate the age of skeletons, a key to studying their origins. Many published ancient genomes lack reliable and direct dates, which results in obscure and contradictory reports. We developed the temporal population structure (TPS), a DNA-based dating method for genomes ranging from the Late Mesolithic to today, and applied it to 3,591 ancie
We consider a numerical approximation of a linear quadratic control problem constrained by the stochastic heat equation with nonhomogeneous Neumann boundary conditions. This involves a combination of distributed and boundary control, as well as both distributed and boundary noise. We apply the finite element method for the spatial discretization and the linear implicit Euler method for the tempora
Calculations of unsteady two-dimensional-flow around rectangular cylinders at incidence are presented. The Reynolds numbers are low ( ⩽ 200), so that the flow presumably is laminar. The results are in reasonable agreement with the indeed scarce experimental data available at these low Reynolds numbers. An incompressible SIMPLEC code is used employing non-staggered grid arrangement. A third-order Q
Cosmogenic radionuclide records (e.g., 10Be and 14C) contain information on past geomagnetic dipole moment and solar activity changes. Disentangling these signals is challenging, but can be achieved by using independent reconstructions of the geomagnetic dipole moment. Consequently, solar activity reconstructions are directly influenced by the dipole moment uncertainties. Alternatively, the known
Background: The instant, single-sampling rule-out of acute myocardial infarction (AMI) is still an unmet clinical need. We aimed at testing and comparing diagnostic performance and prognostic value of two different single-sampling biomarker strategies for the instant rule-out of AMI. Methods: From the Biomarkers in Acute Cardiac Care (BACC) cohort, we recruited consecutive patients with acute ches
Analytical solutions for a one-line model for shoreline changes are employed to investigate the formation of two wave-dominated river delta coastlines, along with a small-scale laboratory experiment. Since the present analytical solution can be applied only to a river delta with infinite shorelines, a new analytical solution was developed to consider the effects of lateral boundaries to the evolut
Analogs of the incretin hormones Gip and Glp-1 are used to treat type 2 diabetes and obesity. Findings in experimental models suggest that manipulating several hormones simultaneously may be more effective. To identify small molecules that increase the number of incretin-expressing cells, we established a high-throughput in vivo chemical screen by using the gip promoter to drive the expression of
Background: There is growing attention and policy debate about the sharing of personal information that the modernization of electricity grids requires. This is particularly important for big data management in smart grids that needs access to data generated and sent through devices such as smart meters. Using the Nordic Countries as a case study, this study investigates the willingness of people
The construction of interfacial engineered heterojunctions is an effective strategy to broaden the optical response and facilitate charge separation. Herein, a novel 0D/1D Ag2S/Sb2S3 heterojunction is prepared by in-situ growth of Ag2S quantum dots on Sb2S3 nanorods using a simple hydrothermal approach. The 10% Ag2S/Sb2S3 (10AS) heterojunction exhibited efficient CO2 photoreduction activity with a
OBJECTIVES: Our aim was to derive, based on the SWEDEHEART registry, and validate, using the Western Denmark Heart registry, a patient-oriented risk score, the SweDen score, which could calculate the risk of 1-year mortality following a myocardial infarction (MI).METHODS: The factors included in the SweDen score were age, sex, smoking, diabetes, heart failure and statin use. These were chosen a pr
Background: Mutations in BRCA2 cause a higher risk of early-onset aggressive prostate cancer (PrCa). The IMPACT study is evaluating targeted PrCa screening using prostate-specific-antigen (PSA) in men with germline BRCA1/2 mutations. Objective: To report the utility of PSA screening, PrCa incidence, positive predictive value of PSA, biopsy, and tumour characteristics after 3 yr of screening, by BR
Purpose: Multiple vendors are currently offering artificial intelligence (AI) computer-aided systems for triage detection, diagnosis, and risk prediction of breast cancer based on screening mammography. There is an imminent need to establish validation platforms that enable fair and transparent testing of these systems against external data. Approach: We developed validation of artificial intellig
The Western Gneiss Region (WGR) is a Precambrian basement domain in the Scandinavian Caledonides and one of the world's largest high- and ultrahigh-pressure terranes. The south–central WGR underwent regional eclogite facies metamorphism 415–400 Ma ago when Baltica subducted beneath Laurentia, during the Scandian orogeny. Eclogites in the WGR group into two traditional types: (1) Precambrian mafic
Esophagectomy is a complex and complication laden procedure. Despite centralization, variations in perioparative strategies reflect a paucity of evidence regarding optimal routines. The use of nasogastric (NG) tubes post esophagectomy is typically associated with significant discomfort for the patients. We hypothesize that immediate postoperative removal of the NG tube is non-inferior to current r
Research on personality traits predicting life outcomes has typically been investigated using the Big Five factors and only occasionally their facets. However, recent research suggests that the use of items (reflecting personality nuances) can account for more predictive variance. The aim of the present study was to examine the predictive validity for various life outcomes comparing the hierarchic
The Saccharomyces cerevisiae Elongator complex consisting of the six Elp1-Elp6 proteins has been proposed to participate in three distinct cellular processes: transcriptional elongation, polarized exocytosis, and formation of modified wobble uridines in tRNA. Therefore it was important to clarify whether Elongator has three distinct functions or whether it regulates one key process that leads to m
Introduction: The Interpersonal-Psychological Theory of Suicide proposes that capability for suicide is acquired through exposure to painful and provocative events (PPEs). Although there is robust evidence for a positive association between aggregate measures of PPEs and risk for suicidal behavior, little is known about the contributions of physical injuries. The present study investigated the rel
