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Complementary measures for the assessment of patient thermoregulatory state, such as subjective judgement scales, might be of considerable importance in field rescue scenarios where objective measures such as body core temperature, skin temperature, and oxygen consumption are difficult to obtain. The objective of this study was to evaluate, in healthy subjects, the reliability of the Cold Discomfo
The molecular basis of type 2 diabetes predisposition at most established susceptibility loci remains poorly understood. KCNQ1 maps within the 11p15.5 imprinted domain, a region with an established role in congenital growth phenotypes. Variants intronic to KCNQ1 influence diabetes susceptibility when maternally inherited. By use of quantitative PCR and pyrosequencing of human adult islet and fetal
AIMS: Lipoprotein lipase (LPL) is a major regulator of triglyceride clearance. A genetic variant of the LPL gene on chromosome 8p22, Asn291Ser, has previously been associated with dyslipidaemia and an increased frequency of cardiovascular disease as well as familial disorders of lipoprotein metabolism. The aim of this study was to test whether the phenotypic expression of the LPL Asn291Ser variant
Popular Abstract in Swedish Oberoende av om det är i ett samhälle, datornätverk eller organen i en mänsklig kropp, så är behovet av kommunikation stort i en komplex miljö. Eftersom den komplicerade människokroppen är beroende av kommunikation för att reglera funktioner, skickas otaliga mängder signaler oavbrutet. För att signalerna skall vara meningsfulla så måste de kunna tas emot och behandlas. Intercellular communication is of crucial importance in regulating physiology and G-protein coupled receptors (GPCRs) have evolved as an important mechanism in this process. Of the approximately 800 human GPCRs, about 160 are still considered to be “orphan” receptors for which an endogenous ligand remains to be identified. Since an estimated 50% of all clinical drugs act on 30 known GPCRs, the rem
This paper quantitatively analyzes the importance of taste versus health in food demand, as well as the effect on consumers’ experienced taste of the non-intrinsic value of healthy labels. Our analysis is based on taste experiments and Vickrey second price auctions on potato chips and bread. Our findings imply a large positive effect on demand for potato chips from higher taste scores: when consum
The short-term evolutionary effect of pheromone-based mating disruption on the mating ability of the Indian meal moth, Plodia interpunctella, was investigated. Three independent selection lines were established, and the mating ability of moths in plastic tents treated with high doses of pheromone and in control tents was compared for two consecutive generations. In addition, the heritability of th
This paper quantitatively analyzes the importance of taste versus health in food demand,as well as the effect on consumers’ experienced taste of the non-intrinsic value of healthy labels. Our analysis is based on taste experiments and Vickrey second price auctions on potato chips and bread. Our findings imply a large positive effect on demand for potato chips from higher taste scores: when consume
The long-lived, light-induced radical Y-D(.) of the Tyr161 residue in the D2 protein of Photosystem 11 (PSII) is known to magnetically interact with the CaMn4 cluster, situated similar to 30 angstrom away. In this study we report a transient step-change increase in YD EPR intensity upon the application of a single laser flash to S, state-synchronised PSII-enriched membranes from spinach. This tran
Protein C inhibitor (PCI) and antithrombin (AT) are serine protease inhibitors (serpins) that are involved in the regulation of coagulation. Like other inhibitory serpins, PCI and AT adopt different structural conformations that are related to their functions. The cleaved, inactive form is a result of cleavage by a protease, and the latent form, which is also inactive, can arise due to a mutation
Social, ecological, and cultural impacts associated with the U.S. military in Hawaii are egregious. However, due to the historical oppressions and injustices to Hawaiians, the U.S. military maintains their hegemony by wielding a disproportionate decisive political and economic power. This study aims to explore perceptions of Native Hawaiian and non-native activists regarding the military impacts a
Sedan det europeiska projektets tidiga dagar har de underliggande ekonomiska motiven för integrationen konfronterats med allmänna intressen såsom oro för miljön. Denna spänning har varit påtaglig, i synnerhet förhållandet mellan nationella åtgärder som syftar till att skydda miljön och allmänna bestämmelser som reglerar EU:s inre marknad. Med tiden har miljöskydd och hållbar utveckling blivit inteSince the early days of the European project the economic rationale of integration has been confronted by public interests such as concerns for the environment. This tension has been tangible particularly in the relationship between national measures aimed at protecting the environment and the general rules governing the internal market. Over time environmental protection and sustainability have b
This paper has its starting point with the discrepancy between the ICPD Plan of Action and the Millennium Development Goals with regards to their separate emphasis on the importance of family planning services as a reproductive health component. The population problem can be looked upon from various theoretical schools. This paper examines the sharply contrasting views of economists, on the one ha
As a transition economy, China faces the reality of shortage of innovation resources and unbalanced allocation of innovation resources among regions when operating innovation activities. In order to solve these two problems, China needs to make efforts in increasing innovation efficiency and narrowing disparities between eastern regions and other regions. Among them, central regions are the area t
Denna uppsats syftar till att fastställa hur införandet av Enhetliga Patent och den Europeiska- och EU-patentdomstolen kommer att påverka läkemedelsindustrins val av patentansökningsförfarande när de ansöker om patent i Europa i framtiden. För att fastställa de förväntade effekterna av Enhetliga Patent på branschen har intervjuer med ett urval personer inom forskning- och utvecklingsföretag och enThis thesis aims to establish how the introduction of the Unitary Patent and the European and European Union Patent Court will affect the pharmaceutical industry’s choice of patent application route when applying for patents in Europe in the future. To establish the expected effect of the Unitary Patent on the industry interviews with a selection of professionals in the research and development in
The peace accord between the government of Colombia and the FARC-guerrilla has caught the attention of the world, not least for its deliberate focus on gender and the inclusion of women in the peace process. This essay aims to investigate the relation between theoretical outlining guidelines presented within the IDDRS framework. As to the construction of Disarmament, Demobilization and Reintegrati
This paper examines the relationship between oil prices and its pass-through to inflation and inflation differentials in the European Monetary Union from the first quarter of 1999 to the last quarter of 2021. By using local projections to derive impulse response functions of an oil price shock, the pass-through to the inflation level is examined focusing on the role of energy-related transmission
Directive 2003/54/EC of the European Commission set the ground for an integrated and liberalized electricity market in Europe. According to the law of one price the possibility for perfect arbitrage and the absence of trade restrictions lead to homogeneous goods being priced uniformly across countries. The aim of this study is to test whether the law of one price is applicable to the electricity m
Volatile conflicts, poverty and suppression of basic human rights stemming from one's political or religious affiliations, gender and race, are some of the various reasons why thousands flee home in the hopes of finding some kind of security. As the world observes the appalling deterioration of conflicts in Western Sudan, Iraq and Haiti, we simultaneously observe neighbouring or developed coun
