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Background Risk factors included in the cardiovascular (CHA2DS2‐VASc) score, currently used for atrial fibrillation (AF), may predispose to cardiovascular events whether or not AF is present. The aim was to explore the predictive role of CHA2DS2‐VASc score on cardiovascular outcomes in diabetic patients without AF. Methods We accessed individual data from 610 diabetic patients without AF at baseli
The title compound forms as biphasic single crystals containing the α- and β-polymorphs. The structure of both polymorphs was solved and refined from single crystal X-ray data in a simultaneous refinement. The structures consist of rods of composition Sb3O4 separated by isolated iodine ions. The two phases differ only in the next nearest neighbour arrangement. The orthorhombic α-phase crystallizes
A search for heavy long-lived multicharged particles is performed using the ATLAS detector at the LHC. Data with an integrated luminosity of 36.1 fb-1 collected in 2015 and 2016 from proton-proton collisions at s=13 TeV are examined. Particles producing anomalously high ionization, consistent with long-lived massive particles with electric charges from |q|=2e to |q|=7e, are searched for. No events
Population ageing affects most European countries, pressurizing pension and care systems. This combination fuels demand for formal and informal care, implying that many, particularly women, are faced with dual responsibilities of paid work and unpaid caregiving. We study the relationship between unpaid caregiving for parents and labor supply (in terms of employment and work hours) among older adul
The isolation, identification and structure of the spalt gene is described. This novel homeotic gene of Drosophila is required for the establishment of the posterior-most head and the anterior-most tail segments of the embryo. It encodes a small mRNA of 0.8 kb which is under the control of over 15 kb of upstream sequences as indicated by the phenotype of transformed embryos. The putative spalt pro
In order to generate monoclonal antibodies (MAb) directed against the low molecular weight glycoprotein alpha 1-microglobulin, a BALB/c mouse was immunized with a mixture of human, guinea pig, rat and rabbit alpha 1-microglobulin homologues (multi-species immunization) and boosted several times. On day 194, the mouse splenocytes were fused to SP2/0 myeloma cells. The resulting hybridomas were scre
Designing high-rise buildings is a complex and challenging task involving several parameters and variables. Recently, there have been major attempts to design the overall form of these buildings based on optimization approaches. This paper introduces a multi-objective optimization framework based on Genetic Algorithm, namely Energy Efficient Form-finder (EEF), consisting of four main steps of Form
The impact of business model innovation (BMI) on business ecosystems, society, and planet is of growing theoretical and practical importance for strategic management. Increasing sustainability pressures warrant a better understanding of the impact of companies’ BMI through a more comprehensive analysis of innovation and its consequences. We discuss four foci of innovation (BMI, sustainable BMI, ec
Adjuvant treatment of nonmetastatic high-risk renal cell carcinoma is an unmet medical need. In the past, several tyrosine kinase inhibitor trials have failed to demonstrate an improvement of disease-free survival (DFS) in this setting. Only one trial (S-TRAC) provided evidence for improved DFS with sunitinib but without an overall survival (OS) signal. Keynote-564 is the first trial of an immune
This document is the final report of the ATLAS-CMS Dark Matter Forum, a forum organized by the ATLAS and CMS collaborations with the participation of experts on theories of Dark Matter, to select a minimal basis set of dark matter simplified models that should support the design of the early LHC Run-2 searches. A prioritized, compact set of benchmark models is proposed, accompanied by studies of t
A search for magnetic monopoles and high-electric-charge objects is presented using 34.4 fb-1 of 13 TeV pp collision data collected by the ATLAS detector at the LHC during 2015 and 2016. The considered signature is based upon high ionization in the transition radiation tracker of the inner detector associated with a pencil-shape energy deposit in the electromagnetic calorimeter. The data were coll
A measurement of the Higgs boson production cross sections via associated WH and ZH production using H→WW⁎→ℓνℓν decays, where ℓ stands for either an electron or a muon, is presented. Results for combined WH and ZH production are also presented. The analysis uses events produced in proton–proton collisions collected with the ATLAS detector at the Large Hadron Collider in 2015 and 2016. The data cor
Water demand growth coupled with its high spatial-temporal mismatch of water resources will lead to an increasing water scarcity worldwide. In order to investigate a robust long-term water stress for ecosystems and regions across China, the improved maximum entropy production (MEP) method was utilized to obtain a reliable evapotranspiration (ET) product during 1982–2015. Afterwards four water stre
Purpose: Air monitoring has been the accepted exposure assessment of toxic metals from, e.g., welding, but a method characterizing the actual dose delivered to the lungs would be preferable. Sampling of particles in exhaled breath can be used for the biomonitoring of both endogenous biomarkers and markers of exposure. We have explored a new method for the sampling of metals in exhaled breath from
PMCA4 is a critical regulator of Ca2+ homeostasis in mammalian cells. While its biological and prognostic relevance in several cancer types has already been demonstrated, only preclinical investigations suggested a metastasis suppressor function in melanoma. Therefore, we studied the expression pattern of PMCA4 in human skin, nevus, as well as in primary and metastatic melanoma using immunohistoch
The transition from fossil jet fuel to biojet fuel is an important step towards reducing greenhouse gas (GHG) emissions from aviation. To enable such a fuel shift, the Swedish Government introduced a GHG emission reduction mandate of 27% by 2030 for aviation fuel sold in Sweden, forcing fuel suppliers to blend in biojet fuel in fossil jet fuel. A similar policy instrument is being discussed within
Latest generations of district heating and cooling systems are characterised by low network temperature with uninsulated pipes, decentralised heat pumps and chillers to modulate the network temperature, and shared energy flows between interconnected buildings. This paper presents a simulation model for the design and analysis of these systems. The model was developed using the Modelica language an
