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Objective: Five double-blind, randomized, saline-controlled trials (RCTs) were included in the United States marketing application for an intra-articular hyaluronan (IA-HA) product for the treatment of osteoarthritis (OA) of the knee. We report an integrated analysis of the primary Case Report Form (CRF) data from these trials. Method. Trials were similar in design, patient population and outcome
Homeodomain-interacting protein kinase 2 (Hipk2) has previously been implicated in the control of several transcription factors involved in embryonic development, apoptosis, cell proliferation, and tumor development, but very little is understood about the exact mechanisms through which Hipk2 influences these processes. Analysis of gene expression in normal tissues from genetically heterogeneous m
Annually laminated sediments of Lake Woserin in north-eastern Germany are investigated using sedimentological and palynological methods. They facilitate high-resolution reconstruction of environmental and land-use change during ca. 7000–4000 cal. BP. Between 6100 and 5800 cal. BP, changes in woodland composition and structure are evident which coincide with a change in subsistence strategy, that i
Objectives: To examine whether the mix of community and institutional long-term care (ILTC) for people with dementia (PwD) in Europe could be improved; assess the economic consequences of providing alternative services for particular groups of ILTC entrants and explore the transnational application of the ‘Balance of Care’ (BoC) approach. Method: A BoC study was undertaken in Estonia, Finland, Fra
IntroductionGovernment and public agencies in Sweden have promoted the expansion of eHealth. The strategy behind many of the eHealth services is to increase quality of care, enhance efficiency, patient empowerment and patient safety. Patient online access to their electronic health record (EHR) is one of the most important civic eHealth services. By 2017, all patients in Sweden will be able to acc
MultiConfiguration Dirac-Hartree-Fock (MCDHF) and relativistic configuration interaction (RCI) calculations were performed for 28 and 78 states in neutral and singly ionized aluminium, respectively. In Al I, the configurations of interest are 3s2nl for n = 3, 4, 5 with l = 0 to 4, as well as 3s3p2 and 3s26l for l = 0, 1, 2. In Al II, in addition to the ground configuration 3s2, the studied configu
The Tsenkher structure in the Gobi-Altai, Mongolia is a c. 3.7 km diameter crater with a well-preserved ejecta blanket. It has been hypothesized to be either of impact or volcanic origin in our previous work. Observations during our 2007 expedition and related sample analyses give further support for an impact origin. The evidence includes the presence of a structurally uplifted near-circular rim
After crossing an initial barrier to break the first base-pair (bp) in double-stranded DNA, the disruption of further bps is characterized by free energies up to a few kBT. Thermal motion within the DNA double strand therefore causes the opening of intermittent single-stranded denaturation zones, the DNA bubbles. The unzipping and zipping dynamics of bps at the two zipper forks of a bubble, where
This paper describes a search for beyond the Standard Model decays of the Higgs boson into a pair of new spin-0 particles subsequently decaying into b-quark pairs, H→aa→(bb¯)(bb¯), using proton-proton collision data collected by the ATLAS detector at the Large Hadron Collider at center-of-mass energy s=13 TeV. This search focuses on the range 15 GeV≤ma≤30 GeV, where the decay products are collimat
Heat integration and industrial symbiosis have been identified as key strategies to foster energy eficient and low carbon manufacturing industries (see e.g. contribution of Working Group III in IPCC's 5th assessment report). As energy efficiency potentials through horizontal and vertical integration are highly specific by site and technology they are often not explicitly reflected in national ener
1. Five groups of male Sprague Dawley rats were given for 6 months a diet with high protein and fat contents but a very low dietary fibre content (group B), and this diet mixed with (g/kg) 50 low-methoxyl pectin (group L), 50 high-methoxyl pectin (group H), 50 guar gum (group G) and 200 wheat bran (group WB, corresponding to 100 wheat fibre) respectively. 2. The weight increment was significantly
OBJECTIVES: Acute Type A aortic dissection remains a life-threatening disease, but there are indications that its surgical mortality is decreasing. The aim of this report was to study how surgical mortality has changed and what influences those changes.METHODS: Nordic Consortium for Acute Type A Aortic Dissection is a retrospective database comprising 1159 patients (mean age 61.6 ± 12.2 years, 68%
Background: Allergic contact dermatitis caused by henna-based hair-colouring products has been associated with adulteration of henna with p-phenylenediamine (PPD). Objectives: To develop a testing approach based on in vitro techniques that address key events within the skin sensitization adverse outcome pathway in order to evaluate the allergenic potential of hair-colouring products. Methods: The
Business challenges today are becoming more numerous, and more urgent. Many companies are expanding beyond their traditional product and market boundaries, while others are forming new alliances or outsourcing supporting functions to other producers. The concept of product-service system (PSS), analysed in this study, has the potential to improve companies’ competitiveness and provide new business
Artikeln presenterar resultat från en enkätundersökning bland 2000 personer bosatta i Sverige. I enkäten ställdes bland annat frågor om synen på förhållandet mellan naturvetenskap och religion. Resultaten ger vid handen att man uppfattar naturvetenskap och religion som kompletterande varandra, och att denna uppfattning är vanligare med högre utbildning. Uttalade ateister uppfattar i hög utsträckni
The Nairobi Summit on ICPD25 provided an opportunity to complete the unfinished business of the International Conference on Population and Development Programme of Action and also a chance to commit to a forward-looking sexual and reproductive health and rights agenda to meet the Sustainable Development Goals and targets by 2030.This background document for the Nairobi Summit on ICPD25 was conceiv
Background: Population-based patient reported outcome data in oesophageal cancer are rare. The main purpose of this study was to describe health-related quality of life (HRQOL) 1 year after the diagnosis of oesophageal cancer, comparing subgroups of curatively and palliatively managed patients. Methods: This is a nationwide population-based cohort study, based on the Swedish National Registry for
