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The cystatin C gene (CST3) encodes a low-molecular-weight cysteine proteinase inhibitor belonging to family II of the cystatin super family and is mutated in cases of hereditary cystatin C amyloid angiopathy (HCCAA). CST3, which along with other family II cystatin genes is a member of the cystatin gene family, has been assigned to chromosome 20. To investigate the genomic organization on chromosom

Background: The national programs for the harmonization of hemoglobin (Hb)A(1c) measurements in the US [National Glycohemoglobin Standardization Program (NGSP)], Japan [Japanese Diabetes Society (JDS)/Japanese Society of Clinical Chemistry (JSCC)], and Sweden are based on different designated comparison methods (DCMs). The future basis for international standardization will be the reference system

The Archean basement in the northeastern part of the Kaapvaal craton is intruded by a large number of mafic dykes, defining three major dyke swarms, which collectively appear to fan out from the Bushveld Complex. Herein we present U-Pb baddeleyite ages for two of these dyke swarms, the northwest trending Badplaas Dyke Swarm and the east-west trending Rykoppies Dyke Swarm, and infer their correlati

Palaeomagnetic and geochronological studies on mafic rocks in the Lake Ladoga region in South Russian Karelia provide a new, reliably dated Mesoproterozoic key paleopole for the East European Craton (Baltica). U-Pb dating on baddeleyite gives a crystallisation age of 1452 +/- 12 Ma for one of the studied dolerite dykes. A mean palaeomagnetic pole for the Mesoproterozoic dolerite dykes. Valaam sill

Artikeln presenterar resultat från en enkätundersökning bland 2000 personer bosatta i Sverige. I enkäten ställdes bland annat frågor om synen på förhållandet mellan naturvetenskap och religion. Resultaten ger vid handen att man uppfattar naturvetenskap och religion som kompletterande varandra, och att denna uppfattning är vanligare med högre utbildning. Uttalade ateister uppfattar i hög utsträckni

I denna uppsats härleds och testas en ny omviktningsalgoritm med vars hjälp det nativa tillståndet av aminosyresekvenser, bestående av 16 aminosyror, kan förutspås. Algoritmen används till att kartlägga de neutrala näten av α-helixes och β-sheets inom ett kontinuerligt proteinmodell. För att undersöka omviktningsalgoritmens potential för att förutsäga den termodynamiska stabiliteten av olika aminIn this thesis, a new reweighting algorithm for predicting the native conformations of amino acid sequences, consisting of 16 residues in a reduced representation continuous protein model, is derived and tested to map neutral nets of α-helices and β-sheets. For examining the potential of the reweighting algorithm for predicting the thermodynamic stability of amino acid sequences, it is applied to

För ca 13 000 år sedan bildades ett skarpt avgränsat mörkare sedimentlager i Barsebäcks mosse, då en sjö, idag ett kärr, i sydvästra Skåne. Detta ”mystiska lager” skiljer sig markant från omgivande lager. Vid tidigare studier samt vid fältkurser med studenter från Lunds universitet har detta mystiska lager dykt upp på några meters djup i borrkärnor. För att lösa mysteriet med hur ”det mystiska lagSediment cores from Barsebäcks mosse, an overgrown lake in southwestern Sweden, display a mysterious sediment layer at a few meters depth. The enigmatic dark-coloured layer is in clear contrast to surrounding light coloured calcareous sediments. A 14C analysis provides an age of 12,760-13,075 cal. yr BP. The dating puts the depositional time to the end of the Late-glacial Allerød warm period. This

En grundläggande utgångspunkt i både den kontradiktoriska rättegången inför allmän domstol och i skiljeförfarande är att parterna svarar för bevisningen. Eftersom tillgången till relevant bevisning ofta är avgörande för utgången i en tvist, är möjligheten att göra gällande en motparts eller tredje mans processuella editionsplikt av central betydelse för en informationsfattig part. Vid framställaIn both adversarial litigation and arbitration, a key principle is that each party is responsible for presenting their own evidence. Since the availability of relevant evidence is often crucial to the outcome of a dispute, the ability to invoke the duty of disclosure from an opposing or third party is of particular importance for a party with limited access to information. Section 26 of the Swed

Humanity is faced with multiple interconnected crises, ranging from the climate breakdown to searing inequalities. There is thus an urgent need to move towards a different socio-political-economic system. Degrowth scholars envision a post-capitalist society centered around ecological and social wellbeing. One way to get there is by building on existing interstitial initiatives. At the same time su

The Tsenkher structure in the Gobi-Altai, Mongolia is a c. 3.7 km diameter crater with a well-preserved ejecta blanket. It has been hypothesized to be either of impact or volcanic origin in our previous work. Observations during our 2007 expedition and related sample analyses give further support for an impact origin. The evidence includes the presence of a structurally uplifted near-circular rim

OBJECTIVES: Acute Type A aortic dissection remains a life-threatening disease, but there are indications that its surgical mortality is decreasing. The aim of this report was to study how surgical mortality has changed and what influences those changes.METHODS: Nordic Consortium for Acute Type A Aortic Dissection is a retrospective database comprising 1159 patients (mean age 61.6 ± 12.2 years, 68%

Background: Allergic contact dermatitis caused by henna-based hair-colouring products has been associated with adulteration of henna with p-phenylenediamine (PPD). Objectives: To develop a testing approach based on in vitro techniques that address key events within the skin sensitization adverse outcome pathway in order to evaluate the allergenic potential of hair-colouring products. Methods: The

PURPOSE: To verify MR measurements of myocardial extracellular volume fraction (ECV) based on clinically applicable T1-mapping sequences against ECV measurements by radioisotope tracer in pigs and to relate the results to those obtained in volunteers.METHODS: Between May 2016 and March 2017, 8 volunteers (25 ± 4 years, 3 female) and 8 pigs (4 female) underwent ECV assessment with SASHA, MOLLI5(3b)

Background: P-selectin is activated early after stroke, followed by a rapid decline. This time course can be used to generate important information on stroke onset. The latter is crucial for therapeutic decision-making of wake-up strokes (i.e. thrombolysis or not). Here, we evaluated the specific p-selectin inhibitor fucoidan labeled with gallium-68 (68Ga-Fucoidan) as an imaging biomarker for asse

The diabetic syndrome of the BB rat shows many homologies with that of human insulin-dependent diabetes and evidence that the onset of the disease is associated with the presence of autoantibodies, including islet cell surface antibodies. In this study, sera were sampled serially from weaning to 157 days of age from 26 BB rats in two low-incidence litters, and 22 rats of three high-incidence litte

Heat integration and industrial symbiosis have been identified as key strategies to foster energy eficient and low carbon manufacturing industries (see e.g. contribution of Working Group III in IPCC's 5th assessment report). As energy efficiency potentials through horizontal and vertical integration are highly specific by site and technology they are often not explicitly reflected in national ener

Background: Listening effort seems to depend on input-related listening demands and several factors internal to the individual listener. Input-related demands may be listening in noise compared with listening in quiet, and internal factors may be cognitive functions. Purpose: The purpose was to apply measures of listening effort and perceived listening effort in participants with normal hearing, t