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Inbreeding depression (ID) has since long been recognized as a significant factor in evolutionary biology. It is mainly the consequence of (partially) recessive deleterious mutations maintained by mutation-selection balance in large random mating populations. When population size is reduced, recessive alleles are increasingly found in homozygous condition due to drift and inbreeding and become mor
BACKGROUND:: In soft tissue sarcoma, better distinction of high-risk and low-risk patients is needed to individualize treatment and improve survival. Prognostic systems used in clinical practice identify high-risk patients based on various factors, including age, tumor size and depth, histological type, necrosis, and grade. METHODS:: Whole-tumor sections from 239 soft tissue sarcomas of the extrem
Although the clinical manifestations of type 2 diabetic nephropathy and decline in kidney function are similar to those in type 1, the clinical course and the renal structural changes are more heterogeneous in type 2 diabetic patients. Previous studies have shown that an increased urine IgM excretion in patients with type 1 diabetic nephropathy was associated with poor outcome. In the present foll
AIM: To evaluate long-term endocrine and exocrine pancreatic function, quality of life and health care costs after mild acute pancreatitis and severe acute pancreatitis (SAP). METHODS: Patients prospectively included in 2001-2005 were followed-up after 42 (36-53) mo. Pancreatic function was evaluated with laboratory tests, the oral glucose tolerance test (OGTT), fecal elastase-1 and a questionnair
Recent animal studies have shown that D-glucose is a potential biodegradable MRI contrast agent for imaging glucose uptake in tumors. Here, we show the first translation of that use of D-glucose to human studies. Chemical exchange saturation transfer (CEST) MRI at a single frequency offset optimized for detection of hydroxyl protons in D-glucose (glucoCEST) was used to image dynamic signal changes
The World Health Organization (WHO) tuberculosis (TB) symptom screening instrument (WHO-TB) can identify human immunodeficiency virus (HIV)-infected individuals at low risk of tuberculosis (TB); however, many patients report WHO-TB symptoms and require further TB investigations. We hypothesized that further clinical scoring could classify subjects with a positive WHO-TB screening result (WHO-TB(+)
Background and purpose Tibial osteotomy by the hemicallotasis technique (HCO) requires strong pin fixation. We compared pin fixation in HCO using a new self-drilling XCaliber pin (Orthofix) with optimized thread and tip design, with the commonly used standard pin (Orthofix). Patients and methods 50 patients, mean age 51 (35-66) years, to be treated by HCO were randomized to standard pins or XCalib
Scand J Caring Sci; 2011 Individual placement and support - a model to get employed for people with mental illness - the first Swedish report of outcomes Lack of participation in the open labour market is highly prevalent for people with a mental illness across countries, and the proportion of people who get some kind of sickness benefit because of mental illness is steadily growing in Europe. Voc
We propose a method for dividing large regions into biogeographical sub-regions based mainly on natural disturbance regime, forest history and potential tree species distribution. This subdivision could be used as a guide when designing conservational strategies and management plans for landscapes and protected areas. At present, conservational strategies and management of valuable areas on the on
The problem of classifying short atrial fibrillatory segments in ambulatory ECG recordings as being either paroxysmal or persistent is addressed by investigating a robust approach to signal characterization. The method comprises preprocessing, estimation of the dominant atrial frequency for the purpose of controlling the subbands of a filter bank, and computation of the relative subband (harmonics
This thesis is devoted to fundamental aspects, and to spectroscopic applications of radiative properties in free atoms and ions, as well as in ions doped into crystals. Using the time-resolved laser-induced fluorescence technique, measurements of radiative lifetimes for rare earth elements have been performed in neutral Pr, Nd, Tm, and in singly ionized Sm, Er, Nd, Tm, Yb, as well as in doubly io
It is investigated how the erasure efficiency for a single bit of data, stored using photon echoes, depends on the data writing time and data storage time. A comparative analysis of the erasure efficiency using a Ti:S laser system and a ring dye laser system is performed. The results clearly establish that the Ti:S laser system, which has a narrower line width than the dye laser system, could be u
Introduction A Swedish data-driven cluster study identified four distinct type 2 diabetes (T2D) clusters, based on age at diagnosis, body mass index (BMI), hemoglobin A1c (HbA1c) level, and homeostatic model assessment 2 (HOMA2) estimates of insulin resistance and beta-cell function. A Danish study proposed three T2D phenotypes (insulinopenic, hyperinsulinemic, and classical) based on HOMA2 measur
This research explores socio-technical perspectives of the demand-side management strategy of using the built environment for short term thermal energy storage. Here conceptualised as a niche innovation within the Danish socio-technical district heating landscapes, the research explores potentials and limitations of this building energy flexibility strategy from the perspective of district heating
C4b binding protein (C4BP) regulates the complement system. It also interacts with anticoagulant protein S and with serum amyloid P component. Human C4BP is composed of seven identical 70-kDa alpha-chains and one 45-kDa beta-chain. The binding site for C4b is located on the alpha-chain, whereas the beta-chain binds protein S. Nothing is known about the structure and function of bovine C4BP. No com
A search is presented for the production of a single top quark via left-handed flavour-changing neutral-current (FCNC) interactions of a top quark, a gluon and an up or charm quark. Two production processes are considered: u+ g→ t and c+ g→ t. The analysis is based on proton–proton collision data taken at a centre-of-mass energy of 13 TeV with the ATLAS detector at the LHC. The data set correspond
BACKGROUND: Anastomotic leaks are associated with significant risk of morbidity, mortality and treatment costs after oesophagectomy. The aim of this study was to evaluate international variation in unit-level clinical practice and resource availability for the prevention and management of anastomotic leak following oesophagectomy.METHOD: The Oesophago-Gastric Anastomosis Audit (OGAA) is an interna
Many astrophysical observations indicate the existence Dark Matter, which is not predicted by the Standard Model (SM) of particle physics. Many theories beyond the Standard Model (BSM) predict new heavy particles called WIMPs (Weakly Interacting Massive Particles). One way to search for WIMP dark matter is through its pair-production in collider experiments. A possible signature, in this case, is
