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The immunosuppressant cyclosporin A (CsA) has been shown to have neuroprotective action. The inhibition of both calcineurin activation and mitochondrial permeability transition pore (mtPTP) opening are considered the primary neuroprotective mechanisms of CsA. Here we have evaluated the effect of CsA on significantly reducing infarct size induced by transient middle cerebral artery occlusion (MCAO)
Distal tephra horizons, particularly within lacustrine sequences, are increasingly being used as time-synchronous marker horizons within palaeoclimatic and palaeoenvironmental investigations. As sedimentary features marking the presence of these so-called cryptotephras are absent to the naked eye, it is of some importance that the stratigraphic position representing primary airfall, and likewise t
Degradation of bovine nasal cartilage induced by interleukin-1 (IL-1) was used to study catabolic events in the tissue over 16 days. Culture medium was fractionated by two-dimensional electrophoresis (isoelectric focusing and SDS-PAGE). Identification of components by peptide mass fingerprinting revealed released fragments representing the NC4 domain of the type IX collagen {alpha}1 chain at days
The six chapters of this study approach the work of Cornelis Vreeswijk from different perspectives with an emphasis on the motifs, poetic technique, and intertextuality of individual songs amd Iyrical texts. Vreeswijks s work is interpreted in the context of contemporary history and debate, the cultural tradition to which it belongs and important events in the author's life. The first chapter foc
Popular Abstract in Swedish Denna avhandling sammanfattar studier av en ny biologisk markör för påvisande av alkoholmissbruk. Alkoholmissbruk är ett omfattande hälsoproblem i många delar av världen och Sverige är inte på något sätt undantaget. Man har beräknat att ca 15% av alla män och 10% av alla kvinnor i detta land står för hälften av all alkoholkonsumtion. Det föreligger alltså en onormal förBiological markers offer a way of assessing ethanol intake and determining whether a health problem is alcohol related. This study investigated the use of phosphatidylethanol (PEth) in blood as a new marker of alcohol abuse. PEth is an abnormal phospholipid, formed only in the presence of ethanol via the transphosphatidylation reaction of phospholipase D (PLD). A new HPLC-evaporative light scatter
The aim of this study was to investigate potential dose reductions to the heart, left anterior descending coronary artery (LAD), and ipsilateral lung for left-sided breast cancer using visually guided deep inspiration breath-hold (DIBH) with the optical surface scanning system Catalyst™, and how these potential dosimetric benefits are affected by intrafractional motion in between breath holds. For
RATIONALE: The alveolar pathology in chronic obstructive pulmonary disease (COPD) involves antigen-driven immune events. However, the induction sites of alveolar adaptive immune responses have remained poorly investigated. OBJECTIVES: To explore the hypothesis that interfaces between the alveolar lumen and lymphoid aggregates (LAs) provide a structural basis for increased alveolar antigen uptake i
Objective To evaluate the psychometric properties of the Fatigue Severity Scale (FSS), the Fatigue Impact Scale (FIS), and the Multidimensional Fatigue Inventory (MFI-20) in persons with late effects of polio (LEoP). More specifically, we explored the data completeness, scaling assumptions, targeting, reliability, and convergent validity. Methods A postal survey including FSS, FIS, and MFI-20 was
We present smoothed particle hydrodynamic models of the interactions in the compact galaxy group, Stephan’s Quintet. This work is extension of the earlier collisionless N-body simulations of Renaud et al. in which the large-scale stellar morphology of the group was modelled with a series of galaxy–galaxy interactions in the simulations. Including thermohydrodynamic effects in this work, we further
Background: Pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH) are rare diseases with a gradual decline in physical health. Adherence to treatment is crucial in these very symptomatic and life threatening diseases. Objective: To describe PAH and CTEPH patients experience of their self-reported medication adherence, beliefs about medicines and informatio
This article presents the results of a questionnaire survey carried out during the spring of 2000. The results are based on the answers provided by a total of 99 respondents. Among other results the survey revealed that more than half of the responding companies have a formally documented strategy for product development work. Regarding disciplinary competencies, it is shown that design engineers
Organometal halide perovskites have attracted tremendous attention for optoelectronic applications. Charge carrier trapping is one of the dominant processes often deteriorating the performance of devices. Here, we investigate the details of trap behavior in colloidal nanoparticles (NPs) of CH3NH3PbBr3 perovskites with mean size of 8 nm and the corresponding bulk crystals (BCs). We use excitation i
Urban tourism depends on the place specific qualities of destinations. In many cities, climate change poses a threat to these qualities, through increasing risk of excessive heat, draught and flooding. Cities need to adapt to reduce these risks. One way of doing this is to improve their green infrastructure. Urban forests, parks, rivers and wetlands may help reduce the effects of climate change in
In current times of global change, several sources of stress such as contaminants and high temperatures may act synergistically. The extent to which organisms persist in stressful conditions will depend on the fitness consequences of multiple simultaneously acting stressors and the genetic basis of compensatory genetic responses. Ivermectin is an antiparasitic drug used in livestock that is excret
Aims: The aim of the study was to describe child health in relation to housing renovations in more than 800 rental units, consisting of repairs of dilapidated kitchens and bathrooms, in the disadvantaged neighbourhood of Herrgården in Rosengård, Malmö, Sweden. Methods: Data on housing conditions and self-reported health were collected during home visits to families living in Herrgården (building r
Very few countries have managed to decouple economic growth from resource use and greenhouse gas emissions in absolute terms and at rates to meet the climate targets of the Paris Agreement. To achieve this, technological solutions would need to be combined with sufficiency-oriented policies in a postgrowth context. This paper develops policy ideas for a sustainable welfare–work nexus via citizen e
Segmentation of grey matter in magnetic resonance images of the spinal cord is an important step in assessing disease state in neurological disorders such as multiple sclerosis. However, manual delineation of spinal cord tissue is time-consuming and susceptible to variability introduced by the rater. We present a novel segmentation method for spinal cord tissue that uses fully convolutional encode
HYPOTHESIS: Self-assembling molecular structures responding to light stimulus are appealing for applications as sensing and drug delivery. Supramolecular nanotubes have a relevant potential in nanotechnology as they can be used to encapsulate different loads like drugs, biological macromolecules, and nanomaterials. In addition, they are suitable elements for novel supracolloidal materials. Structu
Urban tourism depends on the place specific qualities of destinations. In many cities, climate change poses a threat to these qualities, through increasing risk of excessive heat, draught and flooding. Cities need to adapt to reduce these risks. One way of doing this is to improve their green infrastructure. Urban forests, parks, rivers and wetlands may help reduce the effects of climate change in
