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Objectives To update the Assessment of SpondyloArthritis international Society (ASAS)-EULAR recommendations for the management of axial spondyloarthritis (axSpA). Methods Following the EULAR Standardised Operating Procedures, two systematic literature reviews were conducted on non-pharmacological and pharmacological treatment of axSpA. In a task force meeting, the evidence was presented, discussed
Objectives: This is a protocol for a Cochrane Review (intervention). The objectives are as follows:. To evaluate the benefits and harms of stem cell-based interventions for the treatment of stroke in newborn infants compared to control (placebo or no treatment) or stem-cell based interventions of a different type or source.
We currently use Convection-Enhanced Delivery (CED) of the platinum-based drug, carboplatin as a novel treatment strategy for high grade glioblastoma in adults and children. Although initial results show promise, carboplatin is not specifically toxic to tumour cells and has been associated with neurotoxicity at high infused concentrations in pre-clinical studies. Our treatment strategy requires in
Drawing on the review of quality assurance policies in higher education already set out of the introduction, this chapter explores the impact of national quality assurance processes adopted to aid consistency in the judgement of academic standards in UK higher education. Specifically, it will examine the ways in which the processes adopted to support marking and to moderate marks, known collective
The Russian invasion of Ukraine has brought an unprecedented chance to end the existence of harmful stereotype of Central and Eastern Europe as a region where the Kremlin has special interests. It has cost a lot of political efforts to bring Czechia, Poland, or the Baltic states out of this equation and join the Western institutional framework. Now there is enough momentum for doing the same with
Paperboard is a thin and lightweight material made of cellulose fibers and it is an important component in packaging material where it provides stiffness and rigidity. The scope of this work is the development of continuum models, and its numerical treatments, for simulating the processes of converting paperboard into packages. The thesis begins with a general introduction to paperboard and a revi
BACKGROUND AND PURPOSEMyelin water imaging (MWI) is a magnetic resonance imaging technique that quantifies myelin in-vivo. Although MWI has been extensively applied to study myelin-related diseases in groups, clinical use in individual patients is challenging mainly due to population heterogeneity. The purpose of this study was twofold: (1) create a normative brain myelin water atlas depicting the
The International Court of Justice has consistently required a stricter standard of proof for ‘charges of exceptional gravity’. The Bosnia Genocide and Croatia Genocide cases saw the Court require the high standard of ‘fully conclusive’ evidence across all elements of the allegations of genocide. Despite the difficulties associated with obtaining the necessary evidence of the intent of the perpetr
The nature of the few known solar-mass stars simultaneously containing debris disks and planets remains an open question. A number of works have shown that this property appears to be independent of planetary masses as well as of stellar age, but possible correlations with stellar kinematics and metallicity have not been investigated. In this paper, we show that the majority of known stars contain
The CO2 Human Emissions project has generated realistic high-resolution 9 km global simulations for atmospheric carbon tracers referred to as nature runs to foster carbon-cycle research applications with current and planned satellite missions, as well as the surge of in situ observations. Realistic atmospheric CO2, CH4 and CO fields can provide a reference for assessing the impact of proposed desi
The constituents of dark matter are still unknown, and the viable possibilities span a vast range of masses. The physics community has established searching for sub-GeV dark matter as a high priority and identified accelerator-based experiments as an essential facet of this search strategy. A key goal of the accelerator-based dark matter program is testing the broad idea of thermally produced sub-
Inspired by the flow description of su(N) colour calculations, we recently showed how to simplify the spinor-helicity formalism (at the algebra level two copies of complexified su(2)) by treating each Weyl spinor as part of a flow line with definite chirality and momentum. This formalism, dubbed the chirality-flow formalism, eliminates all non-trivial algebra from tree-level spinor-helicity calcul
A search for the K+ → π+X decay, where X is a long-lived feebly interacting particle, is performed through an interpretation of the K+ → π+νν¯ analysis of data collected in 2017 by the NA62 experiment at CERN. Two ranges of X masses, 0–110 MeV/c2 and 154–260 MeV/c2, and lifetimes above 100 ps are considered. The limits set on the branching ratio, BR(K+ → π+X), are competitive with previously repor
The luminosity monitor LUCID (LUminosity Cherenkov Integrating Detector) employed in the ATLAS experiment at the LHC had to be upgraded for the second run of LHC (Run 2) that started in spring 2015. The increased energy of the proton beams and the higher luminosity implied that the Photomultipliers of the original LUCID detector had to be replaced for Run 2 to cope with the more demanding conditio
Objective: For many years, functional tricuspid regurgitation (FTR) was considered negligible after treatment of left-sided heart valve surgery. The aim of the present network meta-analysis is to summarize the results of four approaches to establish the possible gold standard. Methods: A systematic search was performed to identify all publications reporting the outcomes of four approaches for FTR,
Background: Transient tachypnoea of the newborn (TTN) is characterised by tachypnoea and signs of respiratory distress. It is caused by delayed clearance of lung fluid at birth. TTN typically appears within the first two hours of life in term and late preterm newborns. Although it is usually a self-limited condition, admission to a neonatal unit is frequently required for monitoring, the provision
Farmers who keep livestock in large carnivore areas are exposed to threat of predation directly impacting on finances and workload as well as the associated psychological stress indirectly impacting on farmers well-being. So far, little is known about such stress responses. The concept of “stress” or “stress reaction” is often used as an undifferentiated umbrella concept for the experience of nega
In this paper, we analyze one of the early welfare interventions in the Swedish welfare state targeted towards mothers and young children: the introduction of a child day-care system. Because quantitative research on day-cares in historical settings is generally scarce, in this study, we focus on the determinants of day-care enrollment in southern Sweden during the early twentieth century. We use
