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Despite recent improvement in adjuvant therapies, triple-negative, and ER+ subtypes of breast cancer (BC) with metastatic potentials remain the leading cause of BC-related deaths. We investigated the role of phosphatidylinositol-4-phosphate 5-kinase alpha (PIP5Kα), a key upstream factor of PI3K/AKT, and the therapeutic effect of PIP5Kα inhibitor on subtypes of BC. The clinical importance of PIP5K1Despite recent improvement in adjuvant therapies, triple-negative, and ER+ subtypes of breast cancer (BC) with metastatic potentials remain the leading cause of BC-related deaths. We investigated the role of phosphatidylinositol-4-phosphate 5-kinase alpha (PIP5Kα), a key upstream factor of PI3K/AKT, and the therapeutic effect of PIP5Kα inhibitor on subtypes of BC. The clinical importance of PIP5K1

Objective: A pay for performance programme was introduced in 2009 by a Swedish county with 1.6 million inhabitants. A process measure with payment linked to coding for medication reviews among the elderly was adopted. We assessed the association with inappropriate medication for five years after baseline.Design and setting: Observational study that compared medication for elderly patients enrolled

The LHCb system requires high efficiency muon detection into LHC bunch crossing: 95% into a 25 ns time window. To reach such efficiency many parameters of the detector readout apparatus have to be calibrated and adjusted and its channels must be aligned in time. In addition, essential characteristics must be monitored to guarantee a good working condition of the apparatus (to avoid loss of efficie

FK506 binding protein 65 (FKBP65) belongs to a group of proteins termed immunophilins that have a high binding affinity to immunosuppressant drugs as FK506 (tacrolimus) and rapamycin (sirolimus). Treatment of female premenopausal women with tacrolimus, which binds to FKBP65, has been reported to be followed by a strongly increased risk of ovarian cysts. We performed the present study to reveal how

Väpnade aktörer, terrorism och illegal handel (med människor, narkotika och vapen) är alla företeelser som, i varierande omfattning, florerar i fallerade stater. Dessa företeelser återfinns inte minst i Colombia, som trots det inte bedöms vara fallerad. Uppsatsens syfte är att påvisa behovet av kvalitativa och kontextspecifika studier, då vår förförståelse är att analyser av fallerade stater, som

Accessibility is an important factor in land-use planning and several methods have been developed to calculate and to predict it. Nevertheless, it is seldom applied in planning situations, maybe because many land-use planners and elected officials lack the knowledge and resources needed to use traffic models. Consequently, accessibility is often used as a concept and a goal in daily planning, but

A somewhat self-critical discussion of the role played by socio-historical information (e.g. about money in social relations) in historical interpretation of ancient and early Christian history, and of the standpoints of Gerd Theissen, Justin Meggitt and Eckehard and Wolfgang Stegemann in this area. The article also explores the role of sociological or social-scientific models in historical recons

BackgroundMale involvement in maternal health care has proven to be beneficial for improving maternal and child health and is often crucial in areas of family planning and contraceptive use. However, compared to male involvement in maternal health care, male involvement in contraceptive counselling is complex and controversial and thus faces certain challenges. Immigrant men in Sweden are often ac

This paper explores the evolution of Swedish stabilization policies through six policy regimes between 1873 and 2019. We focus on discretionary policy decisions by estimating policy shocks using a SVAR model. Through these shocks, we explore how stabilization policies have evolved over time and how policymakers responded to key economic events such as financial crises and wars. Our results show thThis paper explores the evolution of Swedish stabilisation policies through six policy regimes between 1873 and 2019. We focus on discretionary policy decisions by estimating policy shocks using a SVAR model. Through these shocks, we explore how stabilisation policies have evolved over time and how policymakers responded to key economic events such as financial crises and wars. Our results show th

In recent years, countries, regions, municipalities and the EU Commission have introduced a significant number of innovation policy initiatives under the banner of ‘missions’, ‘societal challenges’, sustainability, and ‘transformation’, or systemic change. In parallel, there has been a rapidly growing body of literature seeking to analyze or assess these real-world manifestations of attempts to pi