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Safe languages like Java provide a much more programmerfriendly environment than the low-level languages in which real-time and embedded software have traditionally been implemented. However, an obstacle for widespread use of Java in control applications has been the predictability and real-time performance of garbage collection, and the cumbersome memory management associated with RTSJ NoHeapReal
Purpose: A cost minimisation analysis compares the costs of different interventions’ to ascertain the least expensive over time. We compared different prostate targeted drug treatments with TURP to identify the optimal cost saving duration of a medical therapy for symptomatic benign prostatic enlargement (BPE). Methods: The Evolution registry is a prospective, multicentre registry, conducted by th
Patient specific QA procedures for IMRT from Lund University Hospital
Background: Surgery for prostate cancer has a large impact on quality of life (QoL). Objective: To evaluate predictors for the level of self-assessed QoL at 3 mo, 12 mo, and 24 mo after robot-assisted laparoscopic (RALP) and open radical prostatectomy (ORP). Design, setting, and participants: The LAParoscopic Prostatectomy Robot Open study, a prospective, controlled, nonrandomised trial of more th
Over the last decade, universities and other institutions of higher education (HEIs) worldwide have witnessed an evolution to their role relative to society – with increasing attention to external engagement and expectations on societal impact. This has fostered an upswing in activity as research and innovation funding bodies and universities alike explore new approaches to working with external eOver the last decade, universities and other institutions of higher education (HEIs) worldwide have witnessed an evolution to their role relative to society – with increasing attention to external engagement and expectations on societal impact. This has fostered an upswing in activity as research and innovation funding bodies and universities alike explore new approaches to working with external e
Background Nocturia is one of the most prevalent and bothersome lower urinary tract symptoms (LUTS) in men, leading to increased morbidity and mortality and a considerable economic burden on healthcare systems. Understanding its natural history, effect of pharmacotherapy, and predictors of failure of pharmacotherapy would allow optimised patient management. Objective To evaluate the prevalence an
Statement of Purpose: Chronic lung diseases are one of the major health problems that cause death and disability. Approximately 65 million people suffer from chronic lung diseases, and the number of patients is predicted to increase worldwide 1 . Lung transplantation is the only available treatment option for patients at end-stage disease. However, there is a chronic shortage of donor organs, re
Statement of Purpose: Many chronic pulmonary diseases, including idiopathic pulmonary fibrosis (IPF), pulmonary hypertension (PH) and chronic obstructive pulmonary disease (COPD), are complex and poorly understood. While great progress has been made to elucidate the cellular and molecular pathways underlying these diseases, treatment options remain limited. The dynamic alterations in mechanical pr
Obesity and cardiometabolic disease often, but not always, coincide. Distinguishing subpopulations within which cardiometabolic risk diverges from the risk expected for a given body mass index (BMI) may facilitate precision prevention of cardiometabolic diseases. Accordingly, we performed unsupervised clustering in four European population-based cohorts (N ≈ 173,000). We detected five discordant p
We compared vaccine effectiveness against severe COVID-19 between December 2021 and March 2022 when Omicron BA.1 and BA.2 were the dominating SARS-CoV-2 variants in Scania county, Sweden. Effectiveness remained above 80% after the transition from BA.1 to BA.2 among people with at least three vaccine doses but the point estimate decreased markedly to 54% among those with only two doses. Protection
Train delays are often monitored using lag indicators of achieved punctuality levels, but indicators can also be used proactively as lead indicators to help reach a certain level of punctuality. In this paper, two lead indicators – the share of delayed dwell times and the share of delayed run times – are formulated and tested on Swedish commuter train data for the years 2001-2020. Results show tha
The consecutive binding of two potassium ions to a bis(18-crown-6) analogue of Tröger’s base (BCETB) in water was studied by isothermal titration calorimetry using four different salts, KCl, KI, KSCN, and K2SO4. A counterintuitive result was observed: the enthalpy change associated with the binding of the second ion is more negative than that of the first (ΔH°bind,2 < ΔH°bind,1). This remarkable f
Cushioned lipid bilayers are structures consisting of a lipid bilayer supported on a solid substrate with an intervening layer of soft material. They offer possibilities for studying the behavior and interactions of biological membranes more accurately under physiological conditions. In this work, we continue our studies of cushion formation induced by histatin 5 (24Hst5), focusing on the effect o
The production team behind the television series Holocaust had a challenging task to find a character who the audience could relate to and try to understand, despite the knowledge that he was deeply involved in the mass executions on the Eastern front. In my paper, I analyse the fictional SS member Erik Dorf (Michael Moriarty). Dorf was based on several people, including the SS officer Otto OhlenThe production team behind the television series Holocaust had a challenging task to find a character who the audience could relate to and try to understand, despite the knowledge that he was deeply involved in the mass executions on the Eastern front. In my paper, I analyse the fictional SS member Erik Dorf (Michael Moriarty). Dorf was based on several people, including the SS officer Otto Ohlen
Introduction: The purpose of this study was to experimentally investigate the effects of changes in both quantity and quality of use of social networking sites (SNS) on measures of anxiety, depression, stress, self-esteem, loneliness, problematic social media use, and present focused awareness. Method: Participants were randomly assigned to three different conditions: reducing SNS time to 30 minut
To make glomerular filtration rate (GFR) estimating equations applicable across populations with different creatinine generation by using rescaled serum creatinine (sCr/Q) where sCr represents the individual creatinine level and Q the average creatinine value in healthy persons of the same population. GFR measurements (mGFR, plasma clearance of 51Cr-EDTA) were conducted in 964 adult Black European
BACKGROUND: There are important unmet clinical needs to develop cell enrichment technologies to enable unbiased label-free isolation of both single cell and clusters of circulating tumor cells (CTCs) manifesting heterogeneous lineage specificity. Here, we report a pilot study based on microfluidic acoustophoresis enrichment of CTCs using the CellSearch CTC assay as a reference modality.METHODS: Ac
Background: High breast density is a risk factor for breast cancer. However, whether density is a prognostic factor is debatable. Also, tumor appearances are related to tumor characteristics. Here we investigate the relationship between breast cancer-specific survival and mammographic breast density and mammographic tumor appearances. Methods: Women in the Malmö Diet and Cancer study with invasive
