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Antibody-free measurement of cerebrospinal fluid tau phosphorylation across the Alzheimer's disease continuum

BACKGROUND: Alzheimer's disease is characterized by an abnormal increase of phosphorylated tau (pTau) species in the CSF. It has been suggested that emergence of different pTau forms may parallel disease progression. Therefore, targeting multiple specific pTau forms may allow for a deeper understanding of disease evolution and underlying pathophysiology. Current immunoassays measure pTau epitopes

Response to the Proposal for a Directive on Corporate Sustainability Due Diligence by Nordic and Baltic Company Law Scholars

On February 23, 2022, The EU Commission published its Proposal for a Directive of the European Parliament and of the Council on Corporate Sustainability Due Diligence and amending Directive (EU) 2019/1937 (“CSDDD” or “the Proposal”). The purpose of the Proposal, to further the “Union’s transition to a climate-neutral and green economy in line with the European Green Deal and in delivering on the U

Endogenous incretin levels and risk of first incident cancer: a prospective cohort study

Concerns have been raised regarding a potentially increased risk of cancer associated with treatment with glucagon-like peptide-1 (GLP-1) receptor agonists. Here, we explored whether fasting and oral glucose tolerance test post-challenge glucose-dependent insulinotropic peptide (GIP) and GLP-1 levels were associated with incident first cancer. Within the cardiovascular re-examination arm of the po

The optimal operative protocol to accomplish CO2-EVAR resulting from a prospective interventional multicenter study

Objectives: Carbon dioxide (CO2) angiography for endovascular aortic repair (CO2-EVAR) is used to treat abdominal aortic aneurysms (AAAs), especially in patients with chronic kidney disease or allergy to iodinated contrast medium (ICM). However, some technical issues regarding the visualization of the lowest renal artery (LoRA) and the best quality image through angiographies performed from pigtai

Impact of Covid- 19 on Science, Education, Health Care, Environment, Economy, and Lifestyle

Epidemics and pandemics are associated with a variety of life-threatening conditions and have serious effects on physical as well as mental wellbeing. The Covid-19 pandemic raised the same difficulties for public and private sectors including schools, businesses, healthcare sectors, etc. The disease, which originated in Wuhan, China in December 2019, has ravaged nearly every country in the world.

Prevalence of serious bacterial infections and management of febrile infants ≤60 days in Swedish Pediatric Emergency Departments

BACKGROUND. The reported prevalence of serious bacterial infections (SBI: urinary tract infection (UTI), bacteremia, and meningitis) among febrile infants ≤60 days of age varies from 8% to 23%. There are indications that the prevalence of infections differs between the sexes. Infants with fever at home but afebrile at the pediatric emergency department (PED) might have a lower risk of SBIs. Furthe

Detection of Brain Tau Pathology in Down Syndrome Using Plasma Biomarkers

Importance: Novel plasma biomarkers, especially phosphorylated tau (p-tau), can detect brain tau aggregates in Alzheimer disease. Objective: To determine which plasma biomarker combinations can accurately detect tau pathological brain changes in Down syndrome (DS). Design, Setting, and Participants: The cross-sectional, multicenter Alzheimer's Biomarker Consortium-Down Syndrome study included adul

Higher education and inclusion : A comparative study of immigrants’ challenges, opportunities and strategies in Sweden and South Africa

This study aims to analyse and compare the challenges and opportunities that refugees and asylum seekers experience in Sweden and South Africa along with the strategies they develop in relation to higher education. As both countries have undertaken a more restrictive refugee and asylum policy, this study hopes to contribute to the debate of inclusion and its challenges. The data-collection entails