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Empiric combination antibiotic therapy (ECAT) is commonly used to treat healthcare-associated bloodstream infections (HA-BSIs) and sepsis. However, the level of supporting evidence is low and clinical practice varies significantly. We conducted a post hoc analysis using the EUROBACT-2 international cohort study database, which contained data on 2406 adult patients from 328 intensive care units (IC
Stormwater management is essential for preventing urban flooding and protecting water quality in receiving bodies. Traditionally viewed as a nuisance, stormwater is now being re-evaluated as an alternative resource for non-potable uses such as toilet flushing and irrigation through rainwater harvesting systems (RWHS). Within the European Union's Horizon 2020 project REWAISE, pilot studies with cer
Galactoglucomannan (GGM) has been identified as a valuable resource and can be used in fields such as oxygen barrier films, food coatings or hydrogels. This hemicellulose can be extracted from softwood using steam explosion (STEX) under mild conditions. However, the GGM-solution also contains impurities such as lignin, lignin-carbohydrate complexes, organic acids, and salts, which require further
Alternative food initiatives are vital for transforming food systems towards sustainability by challenging, replacing, and complementing the status quo. Understanding how these initiatives contribute to transformation requires attention not only to their intended outcomes but also to the processes through which these outcomes contribute to broader social change. Existing assessment frameworks rare
INTRODUCTION: There is substantial heterogeneity in the reporting of outcomes in the global cranioplasty literature. This study aimed to establish a core outcome set (COS) for cranioplasty after decompressive craniectomy for stroke or traumatic brain injury.METHODOLOGY: The scope was defined according to the criteria recommended by the Core Outcome Measures in Effectiveness Trials (COMET) Initiati
This paper explores the challenges and barriers of forced migrants at the nexus of housing and social integration, presenting the outcomes of an international and interdisciplinary collaboration funded by the JPI Urban Europe programme. Research includes the case study cities Leipzig, Lund, Riga, and Vienna, utilizing primary and secondary data in a transdisciplinary process involving theoretical
Multilevel Analysis of Individual Heterogeneity and Discriminatory Accuracy (MAIHDA) is a multilevel regression approach grounded in intersectionality theory. It examines inequalities across intersections of social identities (e.g., gender, ethnicity, class) and is argued to provide more accurate predictions of intersectional means than conventional methods that estimate group means directly or vi
For circular retail models to successfully replace linear consumption in the future, retailers must understand the lived reality of second-hand customer journeys. However, existing customer journey mapping methods often fail to capture the non-linear, phygital, and multi-retailer nature of such journeys. This article introduces ‘messy customer journey self-mapping’, a novel qualitative method desi
Cardiac rehabilitation (CR) is a well established intervention for secondary prevention after myocardial infarction (MI), yet substantial variability in CR delivery and patient outcomes persists globally. This review provides an in-depth overview of the SWEDEHEART-CR registry, a comprehensive Swedish national quality registry that has facilitated continuous quality improvement and clinical researc
The purpose of this work is to identify and analyze the key important barriers to uptake the compressed biogas (CBG) plants in India for enhancing their role as a sustainable energy source. Initially, the barriers are identified from the past academic literature using literature review process and are then validated through the fuzzy Delphi method with expert opinions. The finalized barriers were
The legal opacity of AI technologies has long posed challenges in addressing algorithmic harms, as secrecy enables companies to retain competitive advantages while limiting public scrutiny. In response, ideas such as qualified transparency have been proposed to provide AI accountability within the confidentiality constraints. With the introduction of the EU AI Act, the foundations for human-centri
A crystallogenesis study of human transthyretin using the counter-diffusion method is described as an alternative to conventional convective vapour diffusion and batch approaches for protein crystallization. The X-ray diffraction results show systematic trends that exhibit unique patterns of crystallization and high crystal quality as well as a remarkable degree of coherence within extended crysta
INTRODUCTION: Behavioral and psychological symptoms of dementia (BPSD) are a common driver of suffering and high care needs. We describe the Swedish BPSD registry, founded in 2010 to develop an evidence base for quality improvement in the care of patients with BPSD. Further, we illustrate the potential of the registry by evaluating how individual BPSD affects mortality. METHODS: The registry provi
Combined density functional theory (DFT) and X-ray standing wave (XSW) studies have previously provided evidence for the preferential adoption of an inverted conformation of 2H-TPP on Cu(111) in contrast to the saddle conformation usually favored by porphyrin molecules adsorbed on metals. We experimentally demonstrate, via X-ray photoelectron spectroscopy (XPS) analysis, that the binding energies
Background/Objectives: Antibiotic resistance presents an urgent public health threat. By developing a streamlined and effective method for studying bacteriophage induction, this research marks a step further in understanding how antibiotic-resistant genes might spread across different environments. This knowledge is essential for creating strategies to reduce the spread of antimicrobial resistan
Density functional theory (DFT) thermochemistry of 3d transition-metal complexes is well-known to be sensitive to the amount of exact Hartree-Fock exchange incorporated into the exchange-correlation functional. For example, relative energies of different protonation states of iron-sulfur complexes may vary by hundreds of kJ/mol among different DFT methods. In the present study, we examine the rela
False lumen management of chronic aortic dissections has evolved during the past decade. Thoracic endovascular aortic repair (TEVAR) continues to be the mainstay of endovascular dissection treatment and relies on the adequate sealing of the proximal entry tear. However, TEVAR alone often fails to achieve aortic remodeling due to persistent distal retrograde perfusion of the false lumen with contin
Automated sorption balances are widely used for characterizing the interaction of water vapor with hygroscopic materials. This paper is part of an interlaboratory study investigating the stability and performance of automated sorption balances. A previous paper in this study investigated the mass, temperature, and relative humidity (RH) stability of automated sorption balances by looking at the ma
This report reviews the published results of searches for possible additional scalar particles and exotic decays of the Higgs boson performed by the ATLAS Collaboration using up to 140 fb−1 of 13 TeV proton–proton collision data collected during Run 2 of the Large Hadron Collider. Key results are examined, and observed excesses, while never statistically compelling, are noted. Constraints are plac
