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BACKGROUND: Pramipexole, a dopamine agonist, has demonstrated antidepressant efficacy as an augmentation strategy in unipolar and bipolar depression. However, dopaminergic treatments are associated with impulse control disorders, including gambling disorder, and evidence regarding behavioural risks in psychiatric populations remains limited.METHODS: We conducted a nationwide register-based cohort
Background: Home oxygen therapy (HOT) improves survival in patients with hypoxaemic chronic respiratory disease. Most patients evaluated for HOT are former or active smokers. Oxygen accelerates combustion and smoking may increase the risk of burn injuries and fire hazards; therefore, it is considered a contraindication for HOT in many countries. However, there is variability in the practices and p
Alla dör, men våra upplevelser av livets slut ser olika ut beroende på hur vårt liv och våra relationer sett ut. Denna avhandling undersöker hur genus, ålder och relationer påverkar människors erfarenheter och möjligheter under livets slutskede. I en tid då såväl hälso- och sjukvårdssystemen som informellt vård- och omsorgsgivande är satta under press är det extra viktigt att utveckla kunskap om The way that we die and care for the dying today is changing, related to extended life expectancy, neoliberalization, as well as shifting caring roles in relation to gender. In a time of “care crisis”, both formal and informal care resources are under duress, making the question of how to provide “a good death” complex and contested in new ways. Scholars in public health have posited a health prom
The emergence of new high brilliance and high coherence facilities such as X-ray Free Electron Lasers (XFELs) and 4th generation synchrotrons open a new era in X-ray optics. Dynamical diffraction effects before disregarded are starting to play a role in the beam control of large scale facilities. In the case of XFEL facilities the temporal characteristics of the dynamical diffraction by thin perfe
The requirements on increasing functionality, quality, and, customisation, while reducing cost has lead to the introduction of an architecture centred development process for electronic systems at Volvo Cars. This process enables better control of system integration and achieving non-functional requirements, such as reusability, understandability, etc. The result of the process is a reference arch
From the ultraviolet induced absorption, we have found a broad blue band and little involvement of Pr ions in ultraviolet illumination. Ultraviolet excited photoluminescence and the excitation spectra for visible emission were also measured in Pr:LiNbO3. We estimated photovoltaic constant and photoconductivity by measuring photovoltaic current and voltage with different boundary conditions. With u
Background Exertional breathlessness is commonly assessed using incremental exercise testing (IET), but reference equations for breathlessness responses are lacking. We aimed to develop reference equations for breathlessness intensity during IET. Methods A retrospective, consecutive cohort study of adults undergoing IET was carried out in Sweden. Exclusion criteria included cardiac or respiratory
One of the characteristics of Polish foreign aid is its focus on the ‘transition experience’ and civil society. This specific celebration of the ‘Polish success story’ contrasts sharply with public debates that frequently criticise the weaknesses of Polish civil society and the difficulties in state – non-state relations. The Polish Aid apparatus itself is not immune to these problems, often exhib
This article provides an insight into the world of Polish development workers operating in South Sudan. It shows that the conceptualisations of aid work in terms of a ‘mission’, a unique job with a special, ethical goal, a difficult, risky operation requiring specific skills are not incidental. Instead, the point is made, that such ways of thinking about foreign aid and distant locations are stron
Forskare och praktiker betonar alltmer vikten av tvärvetenskapliga och experimentella sätt att förstå och bemöta hållbarhetsutmaningar. Det finns en bred enighet om att samhället måste genomgå djupa och radikala förändringar, alltså omvandling (transformation). Men detta berorpå många dynamiska faktorer i lokala sammanhang. I denna avhandling utforskar jag hur man kan främja experimentella tvärvetScholars and practitioners increasingly emphasize the importance of transdisciplinary and experimental approaches for understanding and addressing sustainability challenges. While there is widespread agreement that human society must undergo deep and radical changes, or so-called transformation, how transformation happens depends on multiple and dynamic factors in local contexts. In this thesis, I
Fibre-optic based sensing technologies are becoming popular in the field of geophysics since enable long range and high spatial resolution acoustic measurements. In this work, we present preliminary results obtained using quasi-distributed Fibre-Bragg grating sensing and Distributed Acoustic Sensing (DAS) to monitor seismic activities in an operational underground mine. 12 FBGs and 800 metres of f
Aim: The primary objective of this study was to describe demographics and end-of-life treatments of children with cancer at a government tertiary cancer center in India. Methods: A retrospective review was undertaken of medical charts of all children younger than 18 years, who died as inpatients while undergoing treatment at the pediatric oncology department between April and September 2016. Data
The movement of XbaI digested O-DNA in 20 nanometer and O-DNA in 12 nanometer high slits was investigated. We found that DNA moved intermittently and following preferential pathways, indicating an important influence of surface roughness. From these intermittent movements two different mobilities were calculated, the total averaged mobilities and averaged mobilities between the intermittent sticki
Objectives: In India, cervical cancer is the most common cancer among women and makes up for up to 29% of all registered cancer in females. Cancer-related pain is one of the major distressing symptoms for all cancer patients. Pain is characterised as somatic or neuropathic, and the total pain experience is often mixed. Conventional opioids are the backbone of analgesic treatment but are most often
Estimating age distributions, or star formation histories, of stellar populations in the Milky Way is important in order to study the evolution of trends in elemental abundances and kinematics. We build on previous work to develop an algorithm for estimating the age-metallicity distribution which uses the full age-metallicity probability density functions (PDFs) of individual stars. No assumptions
