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Immunoglobulin G (IgG) glycosylation modulates antibody activity and represents a major source of heterogeneity within antibody preparations. Depending on their glycosylation pattern, individual IgG glycovariants present in recombinant antibody preparations may trigger effects ranging from enhanced pro-inflammatory activity to increased anti-inflammatory activity. In contrast, reduction of IgG gly

Protein kinase C (PKC) plays a prominent role in immune signaling, and the paradigms for isoform selective signaling are beginning to be elucidated. Real-time microscopy was combined with molecular and biochemical approaches to demonstrate a role for PKC-epsilon in Fcgamma receptor (FcgammaR)-dependent phagocytosis. RAW 264.7 macrophages were transfected with GFP-conjugated PKC isoforms, and GFP m

The immune processes associated with atherogenesis have received considerable attention during recent years. IgG FcRs (FcgammaR) are involved in activating the immune system and in maintaining peripheral tolerance. However, the role of the inhibitory IgG receptor FcgammaRIIB in atherosclerosis has not been defined. Bone marrow cells from FcgammaRIIB-deficient mice and C57BL/6 control mice were tra

OBJECTIVE: To investigate the possible role of FCGR2A 519A>G and FCGR3A 559A>C functional polymorphisms in the genetic predisposition to susceptibility to systemic sclerosis (SSc) or clinical phenotype. METHODS: A total of 1566 patients with SSc and 2271 geographically matched controls were included in our study. We analyzed the genotype and allele frequencies of the FCGR2A 519A>G and FCGR3A 559A>

In a previous study we presented data indicating that the expanded population of CD4(-)CD8(-) (DN) alphabeta T cells in TCRalpha-chain-transgenic mice was partially if not entirely derived from gammadelta T cell lineage cells. The development of both gammadelta T cells and DN alphabeta T cells is poorly understood; therefore, we thought it would be important to identify the immediate precursors of

The received wisdom has long been that people in Europe reacted with great enthusiasm as war was approaching in August, 1914. However, scholars who have investigated the matter have found little evidence of enthusiasm. There was no unique “spirit of 1914,” and people in general were not happy about the prospect of war. This revisionist thesis is now the new orthodoxy and should as such be subject

Brevmall Postadress Box 117, 221 00 Lund Besöksadress Paradisgatan 5C Telefon 046-222 77 71, 046-222 00 00 E-post anneli.wiklander@fs.lu.se Rektor Föreskrifter rörande hantering av ekonomiska intresse- konflikter relaterade till viss amerikansk forskningsfinansiering Bakgrund I samband med ansökan om forskningsbidrag och för att kunna ta emot forskningsmedel från USA:s statliga finansiärer, särski

https://www.medarbetarwebben.lu.se/sites/medarbetarwebben.lu.se/files/foreskrifter-rorande-hantering-av-ekonomiska-intressekonflikter-relaterade-till-viss-amerikansk-forskningsfinansiering.pdf - 2026-05-19

Desert vernacular architecture has always been the product of a sustainable building cycle. People inherited the traditional way of building from their ancestors and the knowledge was transferred and developed from one generation to another. Inhabitants responded to their environment and climate through trial and error in a way that satisfied their needs and aspirations to create a developing buil

A trend, which can be noted in the field of cash handling, is the increase of ATMs that are able to recirculate banknotes. Cash recycling means that notes deposited by one customer are then available for withdrawal by another from the same machine. Cash recycling has both economic advantages and reduces environment impact, as transport to machines for filling and emptying them can be decreased. Wh

20191022 Inresande forskningspraktikanter (grund- eller masterstudenter) Den internationella kommittén vid Institutionen för psykologi har beslutat om riktlinjer för att skapa bra förutsättningar för ett ömsesidigt givande forskningssamarbete mellan inkommande forskningspraktikanter samt ansvariga forskare. Då du som forskare blir kontaktad av internationella studenter som önskar delta i ett forsk

https://www.psy.lu.se/sites/psy.lu.se/files/inresande_forskningspraktikanter.pdf - 2026-05-19

Particles that are a hundred- to ten thousand times smaller than the width of a hair are commonly referred to as colloidal particles. Colloidal particles occur in a variety of products, like foodstuffs (marmelade and dairy products), construction materials (cement) and stained glass. In water, these particles are strongly affected by the Brownian force: an force that was discovered in 1827 by the Thermoresponsive colloidal microgels expel solvent from their interior upon crossing a threshold temperature, resulting in a significantly reduced size. The collapse of microgels can reversibly switch the interparticle interactions from soft repulsive to attractive, and the accompanying size reduction allows for precise control over volume fraction. Mixing two microgels that collapse at different

https://www.pi.lu.se/evenemang/invisible-nation-screening-film-followed-panel-discussion - 2026-05-17