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Hematopoietic stem cells are an ideal target for genetic manipulation for the purpose of curing hematological disorders as they have the ability to develop into all blood lineages and to self-renew. In this study we demonstrate that lentiviral vectors, based on HIV-1, can efficiently transfer genes into human hematopoietic progenitor and stem cells as assessed following stem cell transplantation i
The paper presents a new family of strategies for swinging up a pendulum. They are derived from physical arguments based on two ideas: shaping the Hamiltonian for a system without damping; and providing damping or energy pumping in relevant regions. A two-parameter family of simple strategies without switches with nice properties is obtained. The main result is that all solutions that do not start
Since year 2000 a number of national energy management systems (EnMS) standards and specifications have been developed. To support EnMS implementation in industry some governments have launched agreements centered around energy management practices. National experiences show that such policy programs can achieve significant energy efficiency improvements. Implementation of industrial EnMSs has gra
Firms began to abandon the “silo” approach to risk management for more integration in the risk management system. Enterprise risk management (ERM) emerged as a framework for the management of integrated risks in a strategy setting supported by risk governance. Practically and empirically there has been no real consensus about what an ERM firm looks like. ERM frameworks provide a variety of concept
A computer-based tool has been developed to support the planning of adaptations for the physically disabled. The prototype development and evaluation were based on six case-studies, which also provided information on the needs and requirements in real-life planning situations. The tool was found useful in supporting an iterative planning process, where it is important to encourage and activate not
Iterative learning control (ILC) is used as a means for task execution of a time sub-optimal trajectory. The use of cascaded ILC procedures in a robot application is experimentally shown to drastically enlarge the region of convergence and efficiently compensate for unmodeled dynamics in the motion system. Objectives considered are the duration of motion, maximum liquid slosh during the motion, an
Peoples' relations to animals and their various roles took many different expressions in the pre-Christian era. In certain contexts animals had practical functions, but others they also had symbolic values. Domsticated animals were a kind of life style metaphors in grave rituals. Wild animals and transformation between humans and animals in pictorial images signified social identity. The archaeolo
In a dispatchable wind power plant, turbines are free to continuously vary their power production as long as the sum of their productions meets the total power demand. Previous research has shown that this freedom can be used to reduce structural loads by allowing turbines in the plant to coordinate their power. This paper explains the mechanisms that make power coordination useful for reducing st
Present digital logic gates are primarily built from field effect transistors (FETs) such as complementary metal oxide semiconductors with the gate length in the deep sub-μm regime. As device feature sizes approach the nanometer regime, fundamental physical constraints and increasingly prohibitive economic costs will make further miniaturization in electronic circuits difficult, and this has motiv
Social anxiety disorder (social phobia) is a debilitating and common anxiety disorder, with a lifetime prevalence ranging from 6 % to 12 %. The condition has its onset in childhood and early adolescence, affects females more often than males, and if untreated is associated with high risk of developing comorbid anxiety and mood disorders, as well as substance abuse. The increasingly growing body of
This book focuses on domain-specific heterogeneous reconfigurable architectures, demonstrating for readers a computing platform which is flexible enough to support multiple standards, multiple modes, and multiple algorithms. The content is multi-disciplinary, covering areas of wireless communication, computing architecture, and circuit design. The platform described provides real-time processing c
In modern chemical process industry, process state transitions, or grade changes, are common operations. Frequent production changes increase the focus on efficient operator support for such procedures. The aims of a grade change may be complex, and sometimes conflicting.Fast transitions are desirable in order to minimize production loss. There may also be safety aspects that must be considered, i
