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The identity of the RNA-binding proteins (RBPs) that govern cancer stem cells remains poorly characterized. The MSI2 RBP is a central regulator of translation of cancer stem cell programs. Through proteomic analysis of the MSI2-interacting RBP network and functional shRNA screening, we identified 24 genes required for in vivo leukemia. Syncrip was the most differentially required gene between norm
The aggregation of the most common natural cyclodextrins (α-, β-, and γ-) in aqueous solutions is addressed by studying the CD-CD interactions using deuterium relaxation rates for deuterium labeled CDs. Relaxation times (T1) and their corresponding relaxation rates (R1 = 1/T1) provide information about the rotational correlation times of CDs and serve as a proxy for solute-solute interactions. Mea
This paper presents two case studies of Swedish ICT 'gap exploiter' companies to provide a nuanced perspective in the investigation of ICT reuse business models and policies. Gap exploiters are third-party firms that create value through the re-utilization of existing products. While extending product life through the gap exploiter model is promising in the transition to a circular economy, busine
Normalisation of measured energy use in buildings is important in order to verify their performance in user phase. Two methods for normalisation have been presented in Sweden, static and dynamic normalisation. The static normalisation considers deviating hot water use, indoor temperature, internal loads and external climate. The dynamic normalisation is based on repeated simulation, meaning that t
A methodology for designing and scaling the performance and thermal characteristics of electric powertrain components is presented. This methodology is aimed at finding optimum component combinations based on a set of requirements. Both drive-cycle performance and specific operating modes such as curb-climbing and maximum wheel speed are considered. This allows the selection of electrical machine
Human intrahepatic lymphocytes are enriched in CD1d-unrestricted T cells coexpressing NKR. Although the origin of this population remains controversial, it is possible to speculate that the hepatic microenvironment, namely epithelial cells or the cytokine milieu, may play a role in its shaping. IL-15 is constitutively expressed in the liver and has a key role in activation and survival of innate a
The likelihood that females will breed or how much they invest in reproduction can depend on the characters of their male partners. Such differential allocation may enhance or limit gene flow between hybridizing lineages, in particular when the lineages have diverged in sexually selected characters. Populations of the common wall lizard (Podarcis muralis) in some regions of Italy exhibit striking
Purpose: The superior soft tissue contrast of magnetic resonance imaging (MRI) compared to computed tomography (CT) has urged the integration of MRI and elimination of CT in radiotherapy treatment (RT) for prostate. An intraprostatic gold fiducial marker (GFM) appears hyperintense on CT. On T2-weighted (T2w) MRI target delineation images, the GFM appear as a small signal void similar to calcificat
The measurement of azimuthal correlations of charged particles is presented for Pb-Pb collisions at sNN=2.76 TeV and p-Pb collisions at sNN=5.02 TeV with the ALICE detector at the CERN Large Hadron Collider. These correlations are measured for the second, third and fourth order flow vector in the pseudorapidity region |η| < 0.8 as a function of centrality and transverse momentum pT using two obser
The ESS Linac project, phase I, requires 12 long pulse klystron modulators with compact footprint, high pulse power and improved quality both on the output pulse waveform and on the input AC power line. Conventional long pulse modulators are typically based on HV pulse transformers and commonly exhibit poor efficiency, low power density, large footprint and cost, with still limited performance on
A new method to determine the concentration of the free protein S in plasma is described. It is an enzyme-linked ligandsorbent assay (ELSA) which utilises the protein S binding capacity of the natural ligand C4b-binding protein (C4BP) to capture the free protein S from plasma samples. The use of C4BP as ligand in the assay is possible due to the high affinity (Kd = 0.1 nM) of the interaction betwe
In 2015 Afghans were the second largest group of asylum seekers in Sweden (and Europe). In this article, I analyze interviews conducted in early 2017 in Scania County with six adult male Afghan asylum seekers, an executive officer at the Swedish Migration Agency, the head of a private asylum seeker camp, and a voluntary worker. I show how the asylum seekers made their way to Sweden not so much thr
The paper presents results from a comparative study of selected biological and technical functions for thermal adaptability, which are based on an extensive literature review in biology and façade engineering. Several selected biological role models have been analysed in detail to identify their principles for dealing with thermal adaptation. These principles have been further abstracted through s
Phosphorylation is a protein post-translational modification (PTM) that plays an important role in cell signaling, cell differentiation, and metabolism. The hyper phosphorylated forms of certain proteins have been appointed as biomarkers for neurodegenerative diseases, and phosphorylation-related mutations are important for detecting cancer pathways. Due to the low abundance of phosphorylated prot
Academic teacher development is an educational meeting place for academics already practising the art of teaching. Yet, it is in courses for this development that academics are supposed to be taught how to teach and how to improve their teaching skills. In my article I propose a new conceptual methodological framework for teaching teachers how to teach – Didactic Reasoning. Its foundation can be t
Background: Quality of supervision is a major predictor for successful PhD projects. A survey showed that almost all PhD students in the Health Sciences in Denmark indicated that good supervision was important for the completion of their PhD study. Interestingly, approximately half of the students who withdrew from their program had experienced insufficient supervision. This led the Research Educa
Summary: Background: In 2014, the Swedish Association of Clinical Physiology recommended the use of a new reference material for exercise capacity in bicycle exercise stress testing, 'the Kalmar material'. Compared to the formerly used reference material, 'the Kristianstad material', an increase in the amount of patients being classified as having decreased exercise capacity was expected, but the
Do Chinese cities compete for investments with lax environmental law enforcement? The here presented study suggests that this is true for some municipalities but not all of them. Based on data for 126 key environmental protection cities and regional economic hubs between 2010 and 2012 we show that economic decentralization and political centralization both shape spatial patterns of compliance with
