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Genetic susceptibility accounts for similar to 35% of all colorectal cancer (CRC). Ten common low-risk variants contributing to CRC risk have been identified through genome-wide association studies (GWASs). In our GWAS, 610 664 genotyped single-nucleotide polymorphisms (SNPs) passed the quality control filtering in 371 German familial CRC patients and 1263 controls, and replication studies were co

Patients with adult acquired flatfoot deformity (AAFD) due to posterior tibial tendon dysfunction (PTTD) may require surgery but few reports have evaluated the outcome.

Parfymföretag har traditionellt sett förlitat sig på sekretess för att skydda sina mest värdefulla tillgångar, parfymdofterna. I modern tid har parfymbranschen blivit alltmer konkurrensbetonad och ett ännu större intresse än tidigare av att skydda värdefulla tillgångar föreligger därför. Det traditionella förlitandet på sekretess för att skydda parfymdofter har i ljuset av modern teknik liten betyPerfume companies have traditionally relied upon secrecy to protect their most valuable assets, their scents. In modern times the perfume business has become very competitive and a greater interest in protecting valuabe assets have arisen. The traditional reliance upon secrecy to protect perfume scents is due to modern technology of little help. Competitors can easily analyze perfume scents as soo

Title: Mapping the usage of returnable packaging material and a proposal for improvements - a Case Study at Haldex AB in Landskrona Author: Annika Jönsson Supervisor: Enes Hasic & Anders Pålsson, Haldex AB, Landskrona Eva Berg, Department of Industrial Management and Logistics, Division of Engineering Logistics, Faculty of Engineering, Lund University Examiner: Jan Olhager, Department of Indus

Background: Arthroscopic partial meniscectomy has been shown to be of no benefit to patients with concomitant knee osteoarthritis, but the optimal treatment of a degenerative meniscus tear in patients with mild or no knee osteoarthritis is unknown. This article describes the rationale and methodology of a randomized sham-controlled trial to assess the benefit of arthroscopic partial meniscectomy o

The incretin - glucose-dependent insulinotropic polypeptide (GIP) - and the pro-inflammatory cytokine osteopontin are known to have important roles in the regulation of adipose tissue functions. In this work we show that GIP stimulates lipogenesis and osteopontin expression in primary adipocytes. The GIP-induced increase in osteopontin expression was inhibited by the NFAT (the transcription factor

A bioanode with high current density and coulombic efficiency was developed by co-immobilization of pyranose dehydrogenase from Agaricus meleagris (AmPDH) with the dehydrogenase domain of cellobiose dehydrogenase from Corynascus thermophiles (recDHCtCDH) expressed recombinantly in Escherichia coli. The two enzymes were entrapped in Os-complex modified electrodeposition polymers (Os-EDPs) with spec

Background: In evaluating complex interventions, it is a challenge for researchers to provide transparent reporting of the intervention content with sufficient detail and clarity such that effects can be compared across studies or countries. Objective: To describe and compare the content of current rehabilitation for patients with inflammatory arthritis across 4 northern European countries. Patien

In this study, the potential of a chitosan-agarose-gelatin (CAG) cryogel scaffold for the repair of subchondral cartilage defects was explored in female New Zealand white rabbits. Custom-made CAG cryogel scaffold was implanted in a surgically created subchondral defect (diameter of 4 mm, depth of 4 mm) in knee joint of rabbit. The repair of the subchondral defect was evaluated at regular time inte

Purpose of the Study: To identify risk factors for early nursing home placement (NHP) in Alzheimer's disease (AD), focusing on the impact of longitudinal change in cognition, activities of daily living (ADL), service utilization, and cholinesterase inhibitor treatment (ChEI). DESIGN AND METHODS: In an open, 3-year, prospective, multicenter study in a routine clinical setting, 880 AD patients were

Syftet med denna studie var att undersöka om rekryterares personlighet, baserat på de personlighetsdimensionerna från Big Five, men även social önskvärdhet, är relaterat till preferens för särskilda rekryteringsmetoder i en rekryteringsprocess. Social önskvärdhet mättes genom den evaluativa faktorn, som kan beskrivas som en preferens för evaluativ information och en tendens att beskriva sig själv

Syringe exchange has been suggested as a potential conduit to treatment for drug dependence, but this never has been documented in Europe. The primary aim was to compare the effectiveness of strength-based case management intervention against referral only to facilitate treatment attendance in a syringe exchange programme. We also assessed effectiveness of a syringe exchange programme for referral

Background: Embolic strokes of undetermined source comprise up to 20% of ischemic strokes. The stroke recurrence rate is substantial with aspirin, widely used for secondary prevention. The New Approach riVaroxaban Inhibition of Factor Xa in a Global trial versus ASA to prevenT Embolism in Embolic Stroke of Undetermined Source international trial will compare the efficacy and safety of rivaroxaban,

BACKGROUND: The cornerstones in the assessment of emergency department (ED) patients with suspected acute coronary syndrome (ACS) are patient history and physical examination, electrocardiogram, and cardiac troponins. Although there are several prior studies on this subject, they have in some cases produced inconsistent results.OBJECTIVE: The aim of this study was to evaluate the diagnostic and pr

Introduction: A new grading of exercise capacity during bicycle stress testing has been proposed in Sweden based on the new reference material (‘the Kalmar material’), which has not been validated. We aimed to examine the prognostic information of the new grading of exercise capacity during exercise stress testing. Methods: Data on all bicycle exercise tests performed at the Department of Clinical