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The recent randomized controlled phase III CLEAR trial results are the last to complement immune checkpoint inhibitor (ICI)-based doublet combination therapies for treatment-naïve metastatic clear-cell renal cell carcinoma. The CLEAR trial demonstrated an improved progression-free survival (PFS), overall survival (OS), and an objective response rate (ORR) benefit for the combination of lenvatinib
BACKGROUND: A resection with clear margins (R0 resection) is the most important prognostic factor in patients with locally recurrent rectal cancer (LRRC). However, this is achieved in only 60 per cent of patients. The aim of this study is to investigate whether the addition of induction chemotherapy to neoadjuvant chemo(re)irradiation improves the R0 resection rate in LRRC.METHODS: This multicentr
OBJECTIVE: Health system resilience can increase a system's ability to deal with shocks like floods. Studying health systems that currently exhibit the capacity for resilience when shocked could enhance our understanding about what generates and influences resilience. This study aimed to generate empirical knowledge on health system resilience by exploring how public antenatal and childbirth healt
Högkvarteren av den satiriska tidningen Charlie Hebdo i Paris blev mål för en dödlig terrorist attack i januari 2015. Syftet med denna studie är att undersöka stigmatiseringen av franska muslimer i ljuset av efterdyningarna av attacken. Denna studie undersöker elva öppna brev som skrevs av franska medborgare i samma månad som tragedin. Jag genomförde en kvalitativ innehållsanalys av breven följand
I juli 2014 föreslog Europakommissionen ett cirkulärt ekonomipaket som skulle bidra till att göra EU mer resurseffektivt genom att recirkulera resurser in i det ekonomiska systemet. En cirkulär ekonomi syftar till att tillvarata värdefulla naturresurser samtidigt som man motverkar behovet av att extrahera nya. Det föreslagna paketet innehöll bland annat ändringar i avfallsdirektiven, höjda återvinIn order to become more resource efficient and circulate resources back into the economic system, the European Commission adapted a circular economy package in 2014. This is in line with the idea of a circular economy. This study investigates how the legislative proposal to review recycling and other waste-related targets in the EU, which was a part of the proposed circular economy package, would
PICT (Pollution Induced Community Tolerance) to Cu is a useful and sensitive tool to assess the effects of Cu pollution in soils under laboratory conditions. However, in field situations, the absence of reference values, i.e. bacterial community tolerance to Cu baseline from non-polluted soils, make the method uncertain when we want to know if a soil is or is not polluted from a microbiological po
A search is presented for the production of the Standard Model Higgs boson in association with a high-energy photon. With a focus on the vector-boson fusion process and the dominant Higgs boson decay into b-quark pairs, the search benefits from a large reduction of multijet background compared to more inclusive searches. Results are reported from the analysis of 132 fb−1 of pp collision data at s
This thesis examines the Multifunctional Land Redistribution Fund, launched in March 2020 by the Danish Ministry of Environment and Food, and the outcomes this policy may propel. The Fund takes aim at multiple issues of sustainability related to land use: biodiversity loss, groundwater contamination, nutrient leaching, and rural development. The Fund is to serve as a pilot project for large-scale
Denna studie undersökte gymnasieelevers sexualkunskapsnivå, deras attityder kring könsroller samt deras benägenhet att acceptera våldtäktsmyter. Våldtäktsmyter innebär falska påståenden kring våldtäkt som anses vara sanningsenliga av allmänheten, men som saknar empiriskt stöd. En webbenkät skickades ut till svenska och finlandssvenska ungdomar. Tre test användes för undersökningen; ett egenkonstru
A search for Higgs boson decays to invisible particles is performed using 20.3 [Formula: see text] of pp collision data at a centre-of-mass energy of 8 TeV recorded by the ATLAS detector at the Large Hadron Collider. The process considered is Higgs boson production in association with a vector boson ([Formula: see text] or Z) that decays hadronically, resulting in events with two or more jets and
This paper presents a search for hypothetical massive, charged, long-lived particles with the ATLAS detector at the LHC using an integrated luminosity of 139 fb−1 of proton–proton collisions at s = 13 TeV. These particles are expected to move significantly slower than the speed of light and should be identifiable by their high transverse momenta and anomalously large specific ionisation losses, dE
Purpose: Histologic grade, Nottingham Prognostic Index (NPI), estrogen receptor (ER) and progesterone receptor (PSR) status, and tumor size have previously been shown to be important prognostic indicators for distant recurrence of breast cancer. The purpose of this study was to compare the prognostic value of these factors with flow cytometric S-phase fraction (SPF), urokinase plasminogen activato
We present a model for developing health services for men who have sex with men (MSM) in sub-Saharan Africa and other places where MSM are heavily stigmatized and marginalized. The processes of the SPEND model include Safe treatment for sexually transmissible infections (STIs) and HIV; Pharmacy sites for treatment of STIs in countries where pharmacies and drug stores are the source of medical advi
Background: Previous studies on domestic violence in Indonesia have focused primarily on women's experiences and little research has been undertaken to understand men's views on domestic violence or their involvement in the prevention of domestic violence. This study aimed to explore men's views on masculinity and the use of violence within marriage, in order to gain knowledge on how to involve me
A search for production of supersymmetric particles in final states containing jets, missing transverse momentum, and at least one hadronically decaying tau lepton is presented. The data were recorded by the ATLAS experiment in root s = 7 TeV proton-proton collisions at the Large Hadron Collider. No excess above the Standard Model background expectation was observed in 2.05 fb(-1) of data. The res
