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BACKGROUND: Children, adolescents, and young adults with cancer (referred to as CAYAs) are at risk of long-term health complications, with cardiovascular disease (CVD) being a major concern. In addition, sociodemographic characteristics and traditional cardiovascular risk factors may also contribute to disparities in outcomes compared with those of the general population. The aim of this study was

This study aimed to investigate the potential impact of neighborhood deprivation on the incidence of type 2 diabetes mellitus (T2DM) among individuals with asthma. This nationwide, open cohort study conducted in Sweden from 1997 to 2018 included asthma patients of all ages (n = 1,051,240) to assess their subsequent risk of developing T2DM. The study compared asthma patients residing in highly depr

Background and aims: Targeted omics techniques can be used to identify systemic blood biomarkers associated with coronary artery disease (CAD) and cardiovascular disease (CVD) events. Our aim was to study associations between plasma protein, metabolite biomarkers and subclinical CAD in a low and a high CVD risk population. Methods: The Swedish CArdioPulmonary bioImage Study (SCAPIS) was used for i

Background We investigate whether, in Swedish national registers, social and psychiatric outcomes for six major psychiatric and substance disorders - drug use disorder (DUD), alcohol use disorder (AUD), major depression (MD), bipolar disorder (BD), anxiety disorder (AD), and schizophrenia (SZ) - reflect the primary genetic risk for each disorder and the level of genetic heterogeneity. Methods We u

IntroductionEquitable access to maternal and reproductive health (MRH) services remains a major challenge in low- and lower-middle-income countries (LLMICs), including Zambia. Despite health system reforms such as the National Health Insurance Scheme (NHIS) and family planning (FP) communication strategies, disparities persist, particularly among socioeconomically disadvantaged populations. This t

Messenger RNA (mRNA) vaccines based on lipid nanoparticles (LNPs) are stabilized with cholesterol, which is thought to be a critical LNP component because it is essential for membrane integrity and endosomal escape. Here, it is shown that cholesterol in LNPs can be replaced with an immunopotentiating lipid, i.e., a synthetic analogue of the C-type lectin receptor agonist monomycoloyl glycerol (MMG

Consumption of ultra-processed food is associated with increased caloric intake and impaired health. Here, we conducted a nutrition trial (NCT05368194) with controlled, 2 × 2 crossover design and tested whether ultra-processed food impairs reproductive and metabolic fitness, with further aggravation by excess caloric intake. Comparing the response from an unprocessed to ultra-processed diet identi

Background Alzheimer's disease (AD) may cause significant psychosocial distress not only in the patient but also their partner. However, long-term risks of major depression in partners of AD patients are largely unknown. Methods A national cohort study was conducted of all 145 289 partners of people diagnosed with all-cause dementia, including 57 113 partners of people diagnosed with AD, in Sweden

Background: Understanding pesticide exposure variability over time among children is crucial towards understanding potential acute and long-term health effects of pesticides but data is lacking. Objective: We assessed spatiotemporal and seasonal variability of urinary biomarkers in children at five time points across two years within three agriculturally intensive areas of the Western Cape, South

Many first trimester sporadic miscarriages are unexplained and the role of environmental exposures is unknown. The present aim was to study if levels of Perfluoroalkyl substances (PFASs) in early pregnancy are associated with unexplained, sporadic first trimester miscarriage. The study was performed within the Swedish SELMA pregnancy cohort. Seventy-eight women with non-recurrent first trimester m

Introduction: Postnatal pesticide exposure and its association with child and adolescent behavioural outcomes remain underexplored in rural agricultural settings, particularly in Africa. This study examined behavioural outcomes in relation to urinary pesticide biomarkers and contextual exposure proxies in participants from the Child health Agricultural Pesticide (CapSA) cohort, South Africa. Metho

Objective: Both attention-deficit/hyperactivity disorder (ADHD) and neighborhood deprivation have been previously associated with an increased risk of type 2 diabetes (T2D). However, the potential association between neighborhood deprivation and T2D in ADHD patients remains underexplored. Our aim was to study the potential effect of neighborhood deprivation on incident T2D in patients with ADHD. M

A Large Ion Collider Experiment (ALICE) has been conceived and constructed as a heavy-ion experiment at the LHC. During LHC Runs 1 and 2, it has produced a wide range of physics results using all collision systems available at the LHC. In order to best exploit new physics opportunities opening up with the upgraded LHC and new detector technologies, the experiment has undergone a major upgrade duri

Background: Alcohol intake increases recurrence of atrial fibrillation (AF), but its relationship with cardiovascular outcomes is less well characterized. We aimed to study the association between different levels of alcohol intake and cardiovascular outcomes in a global cohort of patients with AF. Methods: This is a cross-sectional analysis of the RE-LY AF registry, including 15,400 patients with

Background: CD40 agonists have the potential to enhance the efficacy of standard of care chemotherapy and to trigger antitumor immunity. Preclinical models indicate that the success of this approach depends on appropriate sequencing of chemotherapy with a CD40 agonist. Preliminary efficacy results from the OPTIMIZE-1 Phase II study (NCT04888312) combining mitazalimab (anti-CD40) with mFFX chemothe