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This book is just what we needed to gather the knowledge accumulated on Usher syndrome throughout the past fifteen years. The epidemiology and pathophysiology of the disease are discussed in several chapters. The great importance of an early diagnosis of the disease in affected children in order to provide them with appropriate education and therapeutic choices is suitably emphasized. Present ther
Contrasting Greenland and Antarctic temperatures during the last glacial period (115,000 to 11,650 years ago) are thought to have been driven by imbalances in the rates of formation of North Atlantic and Antarctic Deep Water (the 'bipolar seesaw'). Here we exploit a bidecadally resolved 14C data set obtained from New Zealand kauri (Agathis australis) to undertake high-precision alignment of key cl
This study is based on fine-mode aerosol samples collected in the upper troposphere (UT) and the lowermost stratosphere (LMS) of the Northern Hemisphere extratropics during monthly intercontinental flights at 8.8-12 km altitude of the IAGOS-CARIBIC platform in the time period 1999-2014. The samples were analyzed for a large number of chemical elements using the accelerator-based methods PIXE (part
Here we report new reconstructions of winter temperature and summer moisture during the past millennium in southeastern Sweden, based on stable-isotope data from a composite tree-ring sequence, that further enhances our knowledge and understanding of seasonal climate variability in the Northern Hemisphere over the past millennium. Key features of these new climate proxy records include evidence fo
Vehicular traffic density is a key factor in determining the behaviour of radio overlapping and thus impacts performance of data and safety message communication in Vehicular Ad hoc Networks (VANETs). In this paper, we propose a novel density model for urban traffic systems and employ this model for the purpose of spatial-temporal analysis of radio overlapping. To model traffic density, we conside
Families of asymptotically regular LDPC block code ensembles can be formed by terminating (J, K)-regular protograph-based LDPC convolutional codes. By varying the termination length, we obtain a large selection of LDPC block code ensembles with varying code rates, minimum distance that grows linearly with block length, and capacity approaching iterative decoding thresholds, despite the fact that t
A threshold analysis of terminated braided block codes (BBCs) is presented for the binary erasure channel. Protograph based BBCs (PG-BBCs) are considered, which can be derived by lifting the Tanner graph of a tightly braided block code. They can be interpreted as GLDPC convolutional codes that are structured in a particular way. It is shown that the terminated PG-BBCs have better thresholds than t
Window decoding schedules are very attractive for message passing decoding of spatially coupled LDPC codes. They take advantage of the inherent convolutional code structure and allow continuous transmission with low decoding latency and complexity. In this paper we show that the decoding complexity can be further reduced if suitable message passing schedules are applied within the decoding window.
In this paper we investigate the frame-error correcting performance of two newly developed, non-binary belief propagation based, soft-in/soft-out decoding algorithms when decoding Reed-Solomon codes. We present results for the AWGN channel indicating that non-binary belief propagation can come close to the performance of the binary adaptive Belief-Propagation algorithm or even slightly better when
Addressing the challenges of extreme scale computing re- quires holistic design of new programming models and sys- tems that support those models. This paper discusses the Angstrom processor, which is designed to support a new Self-aware Computing (SEEC) model. In SEEC, applications explicitly state goals, while other systems components provide actions that the SEEC runtime system can use to meet
The Younger Dryas (YD) cold reversal interrupts the warming climate of the deglaciation with global climatic impacts. The sudden cooling is typically linked to an abrupt slowdown of the Atlantic Meridional Overturning Circulation (AMOC) in response to meltwater discharges from ice sheets. However, inconsistencies regarding the YD-response of European summer temperatures have cast doubt whether the
The Holocene Series/Epoch is the most recent series/epoch in the geological timescale, spanning the interval from 11,700 yr to the present day. Together with the subadjacent Pleistocene, it comprises the Quaternary System/Period. The Holocene record contains diverse geomorphological, biological, climatological and archaeological evidence, within sequences that are often continuous and extremely w
The second phase of the Fifth International Ice Nucleation Workshop (FIN-02) involved the gathering of a large number of researchers at the Karlsruhe Institute of Technology's Aerosol Interactions and Dynamics of the Atmosphere (AIDA) facility to promote characterization and understanding of ice nucleation measurements made by a variety of methods used worldwide. Compared to the previous workshop
During the transition from the last glacial into the Holocene interglacial, the atmospheric circulation in the North Atlantic area changed from a glacial mode, influenced by the presence of large ice sheets, into a system more similar to that of the present day. This change had implications for wind, temperature and precipitation patterns that can be traced in geological archives. Here, we focus o
This article summarizes the processes that are responsible for cosmogenic radionuclide variations in ice cores and the results that can be inferred from these records. The article starts with the production in the atmosphere caused by the influx of galactic cosmic ray particles and its modulation by the solar and geomagnetic fields. Subsequently, the geochemical behavior of cosmogenic radionuclide
Timescale uncertainties between paleoclimate reconstructions often inhibit studying the exact timing, spatial expression and driving mechanisms of climate variations. Detecting and aligning the globally common cosmogenic radionuclide production signal via a curve fitting method provides a tool for the quasi-continuous synchronization of paleoclimate archives. In this study, we apply this approach
The volcanic fingerprint on the winter North Atlantic atmospheric circulation and climate is analyzed in six ensemble runs of ECHAM5/MPI-OM covering 800–2000 CE, both for equatorial and Northern Hemisphere (NH) eruptions. Large volcanic eruptions influence climate on both annual and decadal time scales due to dynamic interactions of different climate components in the Earth's system. It is well kn
From December 1993 to January 1995 and from October 2009 to October 2010, a total of 320 and 365 daily samples of the PM2.5 were collected at a rural background site (National Atmospheric Observatory Košetice) in Central Europe. The PM2.5 samples were analyzed for 29 and 26 elements respectively by Particle-Induced X-ray Emission (PIXE) and water-soluble inorganic ions by Ion Chromatography (IC) i
Spatial correlation across an antenna array is known to be detrimental to the terminal signal-to- interference-plus-noise-ratio (SINR) and system spectral efficiency. For a downlink multiuser multiple-input multiple-output system (MU-MIMO), we show that the widely used, yet overly simplified, correlation models which generate fixed correlation patterns for all terminals tend to underestimate the s
