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The contribution of host genetic and nongenetic factors to immunological differences in humans remains largely undefined. Here, we generated bacterial-, fungal-, and viral-induced immune transcriptional profiles in an age- and sex-balanced cohort of 1,000 healthy individuals and searched for the determinants of immune response variation. We found that age and sex affected the transcriptional respo

Closed-loop controlled drug dosing has the potential of revolutionizing clinical anesthesia. However, interpatient variability in drug sensitivity poses a central challenge to the synthesis of safe controllers. Identifying a full individual pharmacokinetic–pharmacodynamic (PKPD) model for this synthesis is clinically infeasible due to limited excitation of PKPD dynamics and presence of unmodeled d

Metastatic melanoma is one of the most common deadly cancers, and robust biomarkers are still needed, e.g. to predict survival and treatment efficiency. Here, protein expression analysis of one hundred eleven melanoma lymph node metastases using high resolution mass spectrometry is coupled with in-depth histopathology analysis, clinical data and genomics profiles. This broad view of protein expres

Various emerging technologies, such as autonomous vehicles and fully autonomous flying, require precision positioning. This work presents a localization and tracking method based on joint direction of arrival (DOA), time delay, and range estimation using the SAGE algorithm. The proposed method does not rely on external sources of information such as global navigation satellite systems (GNSS). The

Generalized alternating projections is an algorithm that alternates relaxed projections onto a finite number of sets to find a point in their intersection. We consider the special case of two linear subspaces, for which the algorithm reduces to matrix multiplications. For convergent powers of the matrix, the asymptotic rate is linear and decided by the magnitude of the subdominant eigenvalue. In t

Sensitivity tests were conducted using a state-of-the-art aerosol–cloud to investigate the key microphysical and dynamical mechanisms by which solid aerosols affect glaciated clouds. The tests involved simulations of two contrasting cases of deep convection—a tropical maritime case and a midlatitude continental case, in which solid aerosol concentrations were increased from their pre-industrial (1

Simulations of a regional (approx. 50 km resolution) circulation model REMOiso with embedded stable water isotope module covering the period 1958-2001 are compared with the two instrumental climate and four isotope series (δ18O) from western Svalbard. We examine the data from ice cores drilled on Svalbard ice caps in 1997 (Lomonosovfonna, 1250 m asl) and 2005 (Holtedahlfonna, 1150 m asl) and the G

Ice core studies have proved thed18O in Greenland precipitation to be correlated to thephase of the North Atlantic Oscillation (NAO). This subject has also been investigated inmodeling studies. However, these studies have either had severe biases in thed18O levels,or have not been designed to be compared directly with observations. In this study wenudge a meso‐scale climate model fitted with stabl

We consider the problem of feasible coordination control for multiple homogeneous or heterogeneous mobile vehicles subject to various constraints (nonholonomic motion constraints, holonomic coordination constraints, equality/inequality constraints etc). We develop a general framework involving differential-algebraic equations and viability theory to describe and determine coordination feasibility

The sensitivity of interglacial Greenland temperature to orbital and CO 2 forcing is investigated using the NorthGRIP ice core data and coupled ocean-atmosphere IPSL-CM4 model simulations. These simulations were conducted in response to different interglacial orbital configurations, and to increased CO 2 concentrations. These different forcings cause very distinct simulated seasonal and latitudina

Future internet-of-things systems need to be able to combine heterogeneous services and support weak connectivity. In this paper, we introduce ComPOS, a new domain-specific language for composing services in IoT systems. We show how Maria, a bird watcher, can use ComPOS to build a system that allows her to spy on birds in the garden while she is not at home. We demonstrate how ComPOS handles the u

BACKGROUND: Robust comparisons of population-based cancer survival estimates require tight adherence to the study protocol, standardized quality control, appropriate life tables of background mortality, and centralized analysis. The CONCORD program established worldwide surveillance of population-based cancer survival in 2015, analyzing individual data on 26 million patients (including 10 million

Current global models of the carbon (C) cycle consider only vertical gas exchanges between terrestrial or oceanic reservoirs and the atmosphere, thus not considering the lateral transport of carbon from the continents to the oceans. Therefore, those models implicitly consider all of the C which is not respired to the atmosphere to be stored on land and hence overestimate the land C sink capability

The Arctic is warming at twice the global average speed, and the warming-induced increases in biogenic volatile organic compounds (BVOCs) emissions from Arctic plants are expected to be drastic. The current global models' estimations of minimal BVOC emissions from the Arctic are based on very few observations and have been challenged increasingly by field data. This study applied a dynamic ecosyst

Monoterpenes emitted from plants have an important role in atmospheric chemistry through changing atmospheric oxidative capacity, forming new particles and secondary organic aerosols. The emission rates and patterns can be affected by changing climate. In this study, emission responses to six years of climatic manipulations (elevated CO2, extended summer drought and night-time warming) were invest

Biogenic volatile organic compound (BVOC) emissions from subarctic ecosystems have shown to increase drastically in response to a long-term temperature increase of only 2°C. We assessed whether this increase takes place already after 3 years of warming and how the increase changes over time. To test this, we measured BVOC emissions and CO2 fluxes in a field experiment on a subarctic wet heath, whe

In this paper we address Industrial IoT control applications which are safety-critical and real-time, and which have very low latency and jitter requirements. These control applications are virtualized as software tasks running on a Fog Computing Platform that brings computing and deterministic communication closer to the edge of the network, where the industrial "things" are located. Due to the d

Modern control algorithms are frequently implemented in a distributed and decentralized way. Multiple fog devices communicate using paradigms borrowed from the Internet-of-Things. These control infrastructures are vulnerable to security threats. This position paper describes these threats and sketches future research on how to mitigate the security concerns that a modern distributed control infras

This chapter contains an outline of the Swedish social security system with a focus on sickness benefits in the social security and unemployment insurance. The Swedish legislator’s ambition has been to create parity between different forms of employment as well as between those who are self-employed and those who operate in different company structures. Legislative amendments in this area have mai