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Background: von Willebrand disease (VWD) type 1 is a congenital bleeding disorder caused by genetic defects in the von Willebrand factor (VWF) gene and characterized by a reduction of structurally normal VWF. The diagnosis of type 1 VWD is difficult because of clinical and laboratory variability. Furthermore, inconsistency of linkage between type 1 VWD and the VWF locus has been reported. Objectiv
[1] The timing of magmatic events forming Jurassic basaltic rocks in Dronning Maud Land (DML), Antarctica, and hydrothermal activity that affected them is addressed with detailed Ar-40/Ar-39 incremental heating dating of feldspars. Plagioclase from an Utpostane gabbro and from a Kirwanveggen dolerite dike yield indistinguishable plateau ages at 177 +/- 1.8 Ma. Because of geologic controls, this es
A research-based understanding of permafrost distribution at a sufficient spatial resolution is important to meet the demands of science, education and society. We present a new permafrost map for Norway, Sweden and Finland that provides a more detailed and updated description of permafrost distribution in this area than previously available. We implemented the CryoGRID1 model at 1km2 resolution,
One-neutron removal cross-sections (σ-1n) of 17,19C in various targets at about 900 MeV/nucleon, and one-proton removal cross-sections (σ-1p) of 8,10B at about 1400 MeV/nucleon were measured using the fragment separator FRS at GSI. A significant increase of σ-1n for 19C compared to its neighbors was observed. The same behavior was found for σ-1p for the neutron-deficient nucleus 8B compared to the
We present parameterized algorithms for the k-path problem, the p-packing of q-sets problem, and the q-dimensional p-matching problem. Our algorithms solve these problems with high probability in time exponential only in the parameter (k, p, q) and using polynomial space. The constant bases of the exponentials are significantly smaller than in previous works; for example, for the k-path problem th
III-V compound semiconductors are used in, among many other things, high-frequency electronics. They are also considered as a replacement for silicon in CMOS technology. Yet, a III-V transistor outperforming state-of-the-art silicon devices in VLSI-relevant metrics has not yet decisively been demonstrated. In this work, the limits of III-V FET performance, for both RF and VLSI applications, are ex
As more people move to cities and urban areas are growing, demand for urban transport increases. This leads not only to pressure on sustainability and climate goals, but also on the attractiveness and liveability of urban areas. Thus, it is necessary to decrease the use of private cars and create a modal shift towards more sustainable modes of transport, such as walking, cycling and public transpo
Ischemic stroke is a leading cause of death and disability worldwide. Currently, there is no treatment that can promote recovery in the chronic phase. It has been shown that neurogenesis occurs in ischemic striatum in rodents and probably also in humans. Moreover, blood-borne macrophages have been found to enhance spontaneous post- stroke recovery in mice. These findings have suggested potentia
Important factors behind high levels of vulnerability and low adaptive capacity to climate variability and change in the developing world are direct reliance on natural resources, poverty and limited abilities to adapt financially and institutionally. In this study, focusing on the Lake Victoria Basin, a multitude of stressors on livelihoods, including climate related factors, are faced by the rur
An overview is given of general-purpose event generators, especially PYTHIA and HERWIG. The current status is summarized, some recent physics improvements are described, and planned future projects are outlined.
Cardiovascular disease is the leading cause of death in the western world. With the application of theoretical physics to the clinic, a variety of imaging technologies are available to the physician for diagnosing and accurately quantifying disease progression. These tools can influence how therapies are applied and impact patient outcome. Radiographic methods based on x-rays are used for diagnosi
[3H]Arachidonic (20:4) and [14C]linoleic acid (18:2) were fed to thoracic duct-cannulated rats in test meals of either tracers alone, cream, Intralipid, pure arachidonic acid, or pure linoleic acid. Less [3H]20:4 than [14C]18:2 was recovered in chyle during the first 5 h. After cream feeding, the proportion of radioactivity found in phospholipids was high and increased during the first 3 h. After
In the management of Parkinson's disease, reliable diagnostic and prognostic biomarkers are urgently needed. The diagnosis of Parkinson's disease mostly relies on clinical symptoms, which hampers the detection of the earliest phases of the disease—the time at which treatment with forthcoming disease-modifying drugs could have the greatest therapeutic effect. Reliable prognostic markers could help
In polaritons, the properties of matter are modified by mixing the molecular transitions with light modes inside a cavity. Resultant hybrid light-matter states exhibit energy level shifts, are delocalized over many molecular units, and have a different excited-state potential energy landscape, which leads to modified exciton dynamics. Previously, non-Hermitian Hamiltonians have been derived to des
This chapter examines the role and responsibilities of the individual academic developer and how these reflect the context of the engagement. It considers how different responses to the development context can be identified - not as a prescription designed to treat each individual case, but as a framework for evaluating the need and creating an environment for meeting it successfully. It will make
The COVID-19 pandemic has presented many challenges that have spurred biotechnological research to address specific problems. Diagnostics is one area where biotechnology has been critical. Diagnostic tests play a vital role in managing a viral threat by facilitating the detection of infected and/or recovered individuals. From the perspective of what information is provided, these tests fall into t
Digital signatures are widely deployed to authenticate the source of incoming information, or to certify data integrity. Common signature verification procedures return a decision (accept/reject) only at the very end of the execution. If interrupted prematurely, however, the verification process cannot infer any meaningful information about the validity of the given signature. We notice that this
The following thesis examines the work of the early swedish transplant surgeons with special regards to the question of organ procurement. Through a careful reading of letters during 1971-1986, left from one prominent swedish transplant surgeons of that time – Sven-Eric Bergentz – I investigate how clinicians sought ways to solve the controversial problem of organ procurement. The institutionaliza
