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Establishment of human embryonic stem cells (hES) from surplus human IVF embryos has been successful when both fresh and frozen-thawed cleavage stage embryos have been cultured to the blastocyst stage. This study reports the characteristics of the starting material, the blastocysts, for hES cell lines that were first derived at the University of Gothenburg, Sahlgrenska University Hospital in 1999.
A high resolution injector system has recently been installed at the Lund 3 MV tandem Pelletron accelerator. The new injector, designed mainly for Al-26 ions, will increase the experimental potential of the Lund AMS facility considerably. High quality energy- and mass-resolution is obtained by using a 90degrees spherical electrostatic analyzer followed by a 90degrees magnetic analyzer. The injecto
Portfolio choice by full-scale optimization applies the empirical return distribution to a parameterized utility function, and the maximum is found through numerical optimization. Using a portfolio choice setting of three UK equity indices we identify several utility functions featuring loss aversion and prospect theory, under which full-scale optimization is a substantially better approach than t
AlSb-V-W-oxide catalysts were prepared and used for propane ammoxidation to give acrylonitrile. The preparations were characterized, both as freshly prepared and after use in propane ammoxidation, using XRD, XPS, Raman spectroscopy, and transmission electron microscopy together with electron diffraction and X-ray microanalysis. Activity tests of the freshly prepared samples reveal a remarkable act
The aim of this study was to determine the number of tibialis anterior biopsy samples and muscle fibers required to estimate the capillary supply of individual muscle fibers (C:F-i). C:F-i was calculated for 25 type 1 fibers in each of 8 images from 3 biopsies of 5 young healthy individuals. Sequential estimation analysis indicated that 50 fibers from one biopsy are sufficient to characterize the
Different ways of approximating the exchange-repulsion energy with a classical potential function have been investigated by fitting various expressions to the exact exchange-repulsion energy for a large set of molecular dimers. The expressions involve either the orbital overlap or the electron-density overlap. For comparison, the parameter-free exchange-repulsion model of the effective fragment po
Tissue-based diagnostics and research is incessantly evolving with the development of new molecular tools. It has long been realized that immunohistochemistry can add an important new level of information on top of morphology and that protein expression patterns in a cancer may yield crucial diagnostic and prognostic information. We have generated an immunohistochemistry-based map of protein expre
We consider a Fermi pencil-beam model in two-space dimensions (x,y), where x is aligned with the beam’s penetration direction and y together with the scaled angular variable z correspond to a, bounded symmetric, transversal cross-section. The model corresponds to a forward–backward degenerate, convection dominated, convection–diffusion problem. For this problem we study some fully discrete numeric
The relationships and the zoogeography of the three extant pinniped families, Otariidae (sea lions and fur seals), Odobenidae (one extant species, the walrus), and Phocidae (true seals), have been contentious. Here, we address these topics in a molecular study that includes all extant species of true seals and sea lions, four fur seals and the walrus. Contrary to prevailing morphological views the
Anaesthesia systems that minimize the use of volatile anaesthetics to reduce cost and pollution are of interest. Closed circuit anaesthesia is the ideal solution, but requires continuous adjustment of fresh gas flow and composition and thus is demanding in routine practice. We describe an alternative system, the Reflector system, which is open in regard to oxygen, nitrogen and N2O, and semiclosed
For the first time we checked the fundamental Gerasimov-Drell-Hearn (GDH) sum rule for the proton experimentally in the photon energy range from 0.2-2.9 GeV with the tagged photon facilities at MAMI (Mainz) and ELSA (Bonn). New data of the doubly polarized total cross section difference are presented in the energy range from 1.6 to 2.9 GeV. The contribution to the GDH integral from 0.2-2.9 GeV yie
Lentiviral vectors have been used extensively as gene transfer tools for the central nervous system throughout the past decade since they transduce most cell types in the brain, resulting in high-level and long-term transgene expression. This review discusses some of the recent progress in this field, including preclinical gene therapy experiments in disease models, development of regulated vector
Through the concept of friction, this article critically examines how the liberal peace travels across differences, accommodates, as well as is accommodated by the spaces it engages, and how it transforms, enables or constrains local as well as international agency. As the liberal peace interplays with the post-conflict realities three sites of friction are identified and examined in the divided c
In spring 1986, Lindsay Anderson appeared in a television programme on British cinema. This was part of a series of three under the heading British Cinema: Personal View, produced by Thames Television. Anderson’s contribution, Free Cinema 1956–? An Essay on Film by Lindsay Anderson, was written and directed by him. He was also the star of the programme, providing a lecture on the history of Britis
ESS will be a premier neutron source facility. Unprecedented neutron beam intensities are ensured by spallation reactions of a 5 MW, 2.0 GeV proton beam impinging on a tungsten target equipped with advanced moderators. The work presented here aims at investigating possibilities for installing an ultra cold neutron (UCN) source at the ESS. One consequence of using the recently proposed flat moderat
In this review, we summarise the current understanding of the potential link between cancer and anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV), including granulomatosis with polyangiitis (Wegener's; GPA) and microscopic polyangiitis (MPA). As is true for many autoimmune or inflammatory rheumatic diseases, AAV diagnosis and therapy are associated with an increased risk of de novo
To develop concise, up-to-date, patient-focused, evidence-based, expert consensus guidelines for the management of knee osteoarthritis (OA), intended to inform patients, physicians, and allied healthcare professionals worldwide.
Radioactive beams of B-14,B-15 produced by fragmentation of a primary Ar-40 beam were directed onto a Pb target to investigate the neutron breakup within the Coulomb field. The experiment was performed at the LAND/(RB)-B-3 setup. Preliminary results for the Coulomb dissociation cross sections as well as for the astrophysically interesting inverse reactions, B-13,B-14(n,gamma), are presented.
First, we study geometric variants of the standard set cover motivated by assignment of directional antenna and shipping with deadlines, providing the first known polynomial-time exact solutions. Next, we consider the following general (non-necessarily geometric) capacitated set cover problem. There is given a set of elements with real weights and a family of sets of the elements. One can use a s
