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OBJECTIVE: Critical limb ischemia (CLI) is a peripheral arterial disease manifested by drastically diminished blood flow to the legs, pain at rest, nonhealing wounds, and gangrene caused by atherosclerosis. Significant tissue necrosis is associated with late stage CLI and the patients have a poor prognosis. Necrotic and apoptotic cells activate complement and bind complement inhibitor C4b-binding
Consider a parametrized family of general hidden Markov models, where both the observed and unobserved components take values in a complete separable metric space. We prove that the maximum likelihood estimator (MLE) of the parameter is strongly consistent under a rather minimal set of assumptions. As special cases of our main result, we obtain consistency in a large class of nonlinear state space
In 2004 at the ATLAS (A Toroidal LHC ApparatuS) combined test beam, one slice of the ATLAS barrel detector (including an Inner Detector set-up and the Liquid Argon calorimeter) was exposed to particles from the H8 SPS beam line at CERN. It was the first occasion to test the combined electron performance of ATLAS. This paper presents results obtained for the momentum measurement p with the Inner De
Evacuation models generally include the use of distributions or probabilistic variables to simulate the variability of possible human behaviours. A single model setup of the same evacuation scenario may therefore produce a distribution of different occupant-evacuation time curves in the case of the use of a random sampling method. This creates an additional component of uncertainty caused by the i
The mechanisms of neuronal cell death are still only poorly understood, which has hindered the advancement of therapies for many currently untreatable neurodegenerative diseases. This calls for the development of new methods which reveal critical molecular mechanisms of the celldeath machinery with both high sensitivity and cellular resolution. Using animal models for hereditary neurodegeneration
In this contribution, a micro-mechanically motivated, energy relaxation-based constitutive model for phase transformation, martensite reorientation and twin formation in shape memory alloys is proposed. The formulation builds on an idealized parametrization of the austenite-twinned martensite microstructure through first- and second-order laminates. To estimate the effective rank-one convex energy
Context. The ESA space astrometry mission Gaia, planned to be launched in 2013, has been designed to make angular measurements on a global scale with micro-arcsecond accuracy. A key component of the data processing for Gaia is the astrometric core solution, which must implement an efficient and accurate numerical algorithm to solve the resulting, extremely large least-squares problem. The Astromet
L-type voltage-gated Ca2+ channels are expressed in the plasma membrane of muscles, neurons and endocrine cells where they serve as conductors of signals regulating cellular responses to changes in environment. Malfunctions of channels, as well as deregulations of their activity underlie numerous disorders and diseases commonly called channelopathies. In β-cells Ca2+ channels are central players f
The article may be seen as a sequel to my paper delivered at a conference on art historical subjectivity and methodology in Stockholm 1999, initiated by Margaretha Rossholm Lagerlöf. – Now I will try to move that analysis a little step further by discussing some problems concerning the more explicit performative effects and experiences of everyday technical objects and their occasionally strange v
Selected reaction monitoring mass spectrometry (SRM-MS) is a targeted proteomics technology used to identify and quantify proteins with high sensitivity, specificity and high reproducibility. Execution of SRM-MS relies on protein-specific SRM assays, a set of experimental parameters that requires considerable effort to develop. Here we present a proteome-wide SRM assay repository for the gram-posi
Recently, the incentive structure facing doctoral students and researchers in economics has changed significantly in many European countries as a result of the adoption of the US approach to evaluating research output. This poses a threat to the development and position of the subject of economics in Europe since evaluation for promotion is characterised by an excessive focus on publishing in the
The search for drugs that modulate NMDA receptors has been very active in the latest decades since they play a pivotal role in neuronal death and in several neurological conditions, including stroke, traumatic brain injury, and neurodegenerative diseases. Activating the receptor evokes an entry of calcium into the neuron, thus leading to a rapid depolarization that can be measured using electrophy
Least squares identification is considered from the Bayesian point of view. A necessary and sufficient condition for consistency almost everywhere is given under the assumption that the data are generated by a regression model with white and Ganssian noise.
We develop a simulation method for Markov Jump processes with finite time steps based in a quasilinear approximation of the process and in multinomial random deviates. The second order approximation to the generating function, Error$=O(dt^{2})$, is developed in detailand an algorithm is presented. The algorithm is implemented for a Susceptible-Infected-Recovered-Susceptible (SIRS) epidemic model a
Since August 2017, more than 655,500 Rohingyas fled from Myanmar to Bangladesh escaping what has been categorized as an Ethnic Cleansing. Their legal status of stateless and non-recognized refugees in Bangladesh, combined with multiple violent encounters and their currently precarious living conditions in Bangladesh is what have turned the world’s attention to The Cox Bazar, where arguably the mos
The release of insulin in vitro from isolated mouse islets was significantly inhibited in the presence of an islet protein extract equivalent to more than 100 times the normal serum level of insulin. The nature of the inhibitory islet substance remains unclear. The possibility that the blood circulation through the islets may be important for the local regulation of insulin release by reducing hig
Pneumothorax occurs more frequently in the neonatal period than at any other time of life and is associated with increased mortality and morbidity. It may be treated with either needle aspiration or insertion of a chest tube. The former consists of aspiration of air with a syringe through a needle or an angiocatheter, usually through the second or third intercostal space in the midclavicular line.
