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The c-kit-encoded tyrosine kinase receptor for stem cell factor (Kit/SCFR) is crucial for the development of hematopoietic cells, melanoblasts, and germ cells. Ligand stimulation of Kit/SCFR leads to receptor dimerization and autophosphorylation on tyrosine residues. We recently showed, that protein kinase C (PKC) acts in an SCF-stimulated negative feedback loop, which controls Kit/SCFR tyrosine k
Growth anomaly of trees in some regions was detected under current episode of rapid warming. Thisraises a dilemma for temperature reconstructions by using tree-ring width which is believed to be themost important proxy on inter-annual temperature reconstruction during the past millenniums. Here weemployed the tree-ring d13C to reconstruct temperature variations for exploring their potential oncapt
In 2000, the Clinton Administration in the U.S. adopted the Commodity Futures Modernization Act, which deregulated the U.S. trade with financial instruments on commodity markets. With respect to this adoption, it has been regarded as one catalyst for the Global food crisis 2008, where millions of individuals lacked provision and access to agricultural products and nutrition. From the perspective o
Hittills har över 50 miljoner ton e-avfall genererats globalt (World Economic Forum, 2019), vilket väcker frågan om den cirkulära ekonomins roll i kampen mot klimatförändringarna (Ellen MacArthur Foundation, 2021). I detta examensarbete undersöks möjligheterna för Axis Communications att införa ett system i USA för att ta tillbaka produkter som tagits ur bruk och återvinna dem. Inom detta område So far, over 50 million tonnes of e-waste have been generated globally (World Economic Forum, 2019), raising the question of the role of circular economy in combating climate change (Ellen MacArthur Foundation, 2021). This thesis explores the opportunities for Axis Communications to introduce a take back system for recycling decommissioned products in the US. Within this scope, several areas are
This thesis explores the socially constructed phenomenon that has arisen as a result of the proliferation of social network sites that has penetrated our daily lives. The qualitative study analysed how university students experienced the global outage of Facebook, Instagram and, WhatsApp on October 4th, 2021, because of the Meta-owned ecosystem of social media. Moreover, the study examined how 2 g
The European Union’s identity as a normative power has long been examined and contested, most famously by Ian Manners' conceptualization in his 2002 work, Normative Power Europe. This study critically reassesses the EU's proposed identity through the lens of its responses to two pivotal crises: the Syrian conflict (2012-2015) and the 2016 EU-Türkiye Refugee Deal. The research interrogates
Current automated haematology systems lack the functionality of avian blood analysis using 10x magnification, which is an important feature as it allows for faster and more cost-effective blood analysis. The problem originates from the difference in red blood cell morphology in avian blood compared to mammalian blood, as the former are nucleated. The project was divided in two objectives, finding
Due to a warming climate, tundra ecosystems are subject to shrub and treeline expansions which could lead to increased above- but decreased belowground carbon (C) stocks. An observed low soil C stock in some subarctic forests and tall shrublands has been suggested to be induced by priming of organic matter decomposition, possibly mediated by ectomycorrhizal fungi. On the other hand, the higher bel
Semantic Web technology has attracted much interest for its ability to integrate and deliver information from different sources, and increasingly, geodata are being published as triple data according to the graph structure laid out in the Resource Description Framework (RDF). Although the Semantic Web already contains a large volume of geotagged information, there is still a lack of suitable geome
Background: Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by tau and amyloid brain pathology. With the gradual degeneration of neurons, cognitive symptoms will arise and the affected individual will eventually develop AD dementia. The neuropathologic hallmarks of AD have been observed also in cognitively healthy individuals, which has led to the assumption that the disorde
With the rise of serious environmental threats brought about by climate change, governments, organizations, leaders, and academics are constantly seeking ways to address this growing concern, and the development of a circular economy model is seen as a viable solution towards ensuring environmental sustainability alongside economic growth. The concept of circular economy has been defined in a mult
Great investments are planned in the north of Sweden the coming years, not the least in the county of Norrbotten where the projects collectively are referred to as the green transition due to the focus on fossil-free techniques. But to be able to secure a sustainable energy supply and reach the goal set by the member states of the European Union of a carbon dioxide neutral union in 2050 the produc
Type 2 diabetes mellitus (T2DM) in children and adolescents is increasing in the world and the United States of America (US). Previous research has shown that the nurse has an important role in the management of T2DM in children and adolescents but few studies has covered how the nurses perceive and experience this role. This paper aimed to describe how nurses in the US experience their role and t
Olympic legacy was previously seen as a potential burden on the host city, however an evolutionary shift has occurred whereby it can now be regarded as an instrument in wider urban policy planning. Sustainable development is a requirement set by some governments, and London 2012 aimed to use the Olympic legacy for sustainable development in the form of urban regeneration. This paper is a case stud
Seeing how climate change disproportionately affects women and children, the voices of young people and women are vital to incorporate into discussions and decision-making processes regarding climate change. This thesis explores the experiences of young women in the climate movement who have participated at the COP climate conferences between 2015-2023. By drawing on the theoretical framework of f
The European spruce bark beetle (Ips typographus L.) is a major disturbance agent in Norway spruce (Picea abies (L.) Karst) forests in Europe and it is estimated that a changing climate will result in more severe outbreaks in the future. To reduce the risk of large outbreaks it is important to have methods that enable early detection of bark beetle attacks to help forest managers to prevent popula
BACKGROUND: Smoking cessation treatment is an important prognostic factor for survival after a cancer diagnosis, especially for tobacco-related cancers. After being diagnosed with lung cancer, approximately 50% of patients continue smoking or frequently relapse after a quit attempt. Given the importance of smoking cessation treatment for cancer survivors, the objective was to compare the effective
