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In the present study, the involvement of cytochrome P450 enzyme( s) in the primary metabolism of laquinimod, a new orally active immunomodulator, has been investigated in human liver microsomes. Hydroxylated and dealkylated metabolites were formed. The metabolite formation exhibited single enzyme Michaelis-Menten kinetics with apparent K-M in the range of 0.09 to 1.9 mM and V-max from 22 to 120 pm
It is now more than two decades since Jane Summerton published her landmark book District Heating Comes to Town about the successful development of a district heating system in an ‘ordinary’ town in Sweden. It was published when sociotechnical studies of urban technical systems were still relatively rare, and arrived during a fertile period of intellectual development that was striving to connect
Fokus för forskningen kan sammanfattas med orden vardag, hälsa och välbefinnande. Aktivitet, dess komplexitet, mening och vilken betydelse det har för människors upplevelse av hälsa och välbefinnande – är centralt. Vi som är organiserade i gruppen arbetar i varierande omfattning med undervisning, forskning och med att sprida våra resultat till brukare och olika verksamheter i samhället.The research in the Occupational therapy and occupational science-group is focused on occupation, health and wellbeing. The complexity, meaning and importance of the concept of everyday occupations for people’s health, is the key. The group works to a varying extent at teaching, research and dissemination of our results to users, in the society.
Avdelningens uppdrag är underhåll, fastighetsskötsel samt leverans av tjänster gentemot såväl externa parter, som fakultetens interna verksamheter. Avdelningen ansvarar även för: besiktning, underhåll och reparationer av instrument och utrustning enligt serviceavtal med brukare. att ta emot felanmälningar och beställningar från verksamheten. verksamheten i receptionerna på BMC och CRC. hj
Substrate and product inhibition of hydrogen production during sucrose fermentation by the extremely thermophilic bacterium Caldicellulosiruptor saccharolyticus was studied. The inhibition kinetics were analyzed with a noncompetitive, nonlinear inhibition model. Hydrogen was the most severe inhibitor when allowed to accumulate in the culture. Concentrations of 5-10 mM H2 in the gas phase ( partial
Cloud RAN (C-RAN) is a promising paradigm for the next generation radio access network infrastructure, which offers centralised and coordinated base-band signal processing in a cloud-based BBU pool. This requires extremely low latency responses to achieve real-time signal processing. In this paper, we analysed the challenges to introduce cloud native model for signal processing in C-RAN. We studie
This paper attempts to address the failings of a predominant paradigm in IS research and practice that emphasises technological determinism. This paradigm makes use of a false belief in the power of rationality in organizational decision-making, and a mythology in which organizational actors can be viewed as passive ‘users’ of technology. We wish to create a discussion of the nature and role of pr
District heating systems make an important puzzle piece in the energy system of both today and tomorrow. When designing, simulating and controlling these systems, hydraulics play a vital role. The pressure generated by pumps has to drive sufficient flow throughout the system to satisfy the requirements of customers. Ensuring that the system is sufficiently pressurized is a challenging task already
Protection against mucosally transmitted infections probably requires immunity at the site of pathogen entry(1), yet there are no mucosal adjuvant formulations licensed for human use. Polyethyleneimine (PEI) represents a family of organic polycations used as nucleic acid transfection reagents in vitro and DNA vaccine delivery vehicles in vivo(2,3). Here we show that diverse PEI forms have potent m
Global Health has not featured as prominently in the European Union (EU) research agenda in recent years as it did in the first decade of the new millennium, and participation of low-income and middle-income countries (LMICs) in EU health research has declined substantially. The Horizon Europe Research and Innovation Framework adopted by the European Parliament in April 2019 for the period 2021-20
This article studies the Kyoto Protocol’s CDM as an example of hybrid governance, involving both public and private actors, and uses the concept of agency to explore the influence of public and private actors in the governance of the CDM over time. Even though public actors formally govern the CDM, the delegation of project implementation and supervision to private companies has created ample oppo
Following the 2008–2009 global financial crisis, ‘green energy economy’ packages have been implemented to stimulate sustainable economic growth in several Organisation for Economic Co-operation and Development (OECD) countries. Clearly focused on the energy sector, these packages typically include energy-efficiency policy measures and aim to encourage the transition towards a low-carbon economy. W
It is likely that everyone will, at some time, suffer from a problem related to the musculoskeletal system, ranging from a very common problem such as osteoarthritis or back pain to severely disabling limb trauma or rheumatoid arthritis. Many musculoskeletal problems are chronic conditions. The most common symptoms are pain and disability, with an impact not only on individuals’ quality of life bu
