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The ups and downs of T cells The role of costimulatory molecules in the modulation of T cell responses

Popular Abstract in Swedish Manniskan utsatts dagligen for sjukdomsframkallande bakterier och virus, vilka maste tas omhand och oskadliggoras. Var hud och slemhinnor fungerar som ett forsta fysiskt och biokemiskt skydd. De som tar sig forbi denna barriar angrips av vart immunforsvar. De vita blodkropparna ar de celler, som snabbast rycker ut till vart forsvar och ater upp och forstor angriparen. DT cell activation requires the combination of antigen in the context of MHC and costimulatory molecules to induce a functional immune response. For our studies, we primarily utilized superantigens (SAg) that bind MHC class II molecules as first signal. Mutations in the SAg MHC class II a-chain binding site reduced the number of responding T cells expressing particular TCR Vb chains, whereas mutati

A story about how MR-imaging grew up in Lund.

Ett av mina första uppdrag som nybliven professor i Medicinsk Strålningsfysik vid Lunds Universitet var att i slutet av april 1981 åka till München för att delta i en Europeisk (EU) workshop om möjligheterna att reducera patient bestrålning vid röntgendiagnostik. Av deltagarna från Storbritannien framkom att man på flera håll i Storbritannien utvecklade metoder för medicinsk avbildning utan röntge

Cellular and Molecular Interplay in Bone Homeostasis and Healing

Bone is a complex hierarchical structure mainly comprising of a matrix of collagen and hydroxyapatite. The main physiological functions of bone include regulating skeletal remodeling, calcium homeostasis and providing a congenial environment to the bone marrow cells to reside and these physiological processes are intricately regulated by various cell types and biomolecules. During trauma to the sk

Homogeneous charge compression ignition operation with natural gas: Fuel composition implications

Homogeneous charge compression ignition (HCCI) is a potentially attractive operating mode for stationary natural gas engines. Increasing demand for efficient, clean burning engines for electrical power generation provides an opportunity to utilize HCCI combustion if several inherent difficulties can be overcome. Fuel composition, particularly the higher hydrocarbon content (ethane, propane, and bu

Laboratory wavelengths for cosmological constraints on varying fundamental constants

Cosmological investigations, using high-redshift quasi-stellar object (QSO) absorption spectra, of possible variations of the fine-structure constant (alpha) require very accurate laboratory wavelengths for a number of resonance transitions from several different species. A change in alpha could be detected as a shift in the wavelengths of atomic transitions in the QSO systems and to accurately de

Cassava Processing: Safety and Protein Fortification

Popular Abstract in Swedish Kassava är ett stärkelserikt livsmedel, jämförbart med potatis. Det produceras främst i jordens tropiska regionerna och är ett viktigt livsmedel i Afrika söder om Sahara. Kassava har stora fördelar som gröda eftersom avkastningen är hög, den har god motståndskraft mot sjukdomar, den växer även på mager jord och den är motståndskraftig mot torka. Emellertid, kassava har Cassava (Manihot esculenta Crantz) is an important and cheap source of carbohydrate in tropical regions, particularly in Sub-Sahara Africa. Cassava as a human food is a good source of energy as it has a comparable high energy density of about 610 kJ/100 g fresh root. The crop has growth advantages and production can take place in soil where other crops such as maize, sorghum and sweet potatoes can

Sankt Marcellus och draken: De alkemistiska tolkningarna av en fransk 1100-talsskulptur

I centrum för avhandlingen står en staty av Marcellus, enligt legenden staden Paris förste biskop. Den placerades vid slutet av 1100-talet som trumeaupelare i Porte Sainte-Anne, den högra av de tre portalerna på Notre-Dames västfasad. En första del av studien ger skulpturens historia, sådan den framställes i den konsthistoriska forskningen, och dess tolkning genom Marcelluslegenden. Ett grundlägga

Use of Casual Loop Diagrams and Systems Analysis to Explore Alternative Climate Change Adaptation Strategies in Seyhan River Basin, Turkey

Within a UN Joint Programme titled “Enhancing the Capacity of Turkey to Adapt to Climate Change” a systems approach workshop was carried out in Adana, Turkey with broad stakeholder participation. The participants applied systems thinking approach, causal loop diagramming methodology and systems analysis to examine the potential impacts of projected climatic changes on natural ecosystems and socio-

Structural and Thermodynamic Studies on Cation- Interactions in Lectin-Ligand Complexes: High-Affinity Galectin-3 Inhibitors through Fine-Tuning of an Arginine-Arene Interaction

The high-resolution X-ray crystal structures of the carbohydrate recognition domain of human galectin-3 were solved in complex with N-acetyllactosamine (LacNAc) and the high-affinity inhibitor, methyl 2-acetamido-2-deoxy-4-O-(3-deoxy-3-[4-methoxy-2,3,5,6-tetrafluorobenzamido]--D-galactopyranose)--D-glucopyranoside, to gain insight into the basis for the affinity-enhancing effect of the 4-methoxy-2

Excess och aktionskonst en semiotisk analys av Hermann Nitschs Das 6-Tage-Spiel med betoning på första dagens Mittagsfinale

The subject for this dissertation is the Austrian artist Hermann Nitsch’s Das 6-Tage-Spiel (1998). The purpose is to examine in what way Das 6-Tage-Spiel, as part of the orgien mysterien theater (hereafter o. m. theater), is an adequate means to realize Nitsch’s intention (as he has described them outside of the work in writings and interviews). Das 6-Tage-Spiel is an example of a category of scen

Political comedy engagement : Genre work, political identity and cultural citizenship

Politisk komedi är en hybridgenre där politiska nyheter och analyser blandas med komedi och underhållning. Allt eftersom politisk komedi ökar i popularitet – i de flesta medieformer och nationella kontexter – arbetar forskare med att förstå dess roll i relation till medborgarskap, och det kan konstateras att genren utmanar den vetenskapliga förståelsen av politiska medier och medborgarskap. Denna Political comedy is a hybrid genre that mixes political news and analysis with comedy and entertainment. As it becomes more and more popular in most media forms and national contexts, researchers struggle to understand its role in relation to other types of political media, and of citizenship; in this sense, it challenges scholarly conceptualisation of political media and citizenship. Thus, this t

On the Programming and System Integration of Robots in Flexible Manufacturing

Popular Abstract in Swedish Robotar är maskiner som rör sig efter hur man programmerar dem. I industriellt bruk monteras ofta ett verktyg på roboten så att den kan svetsa, gripa, slipa, borra eller göra andra saker. Det som gör roboten bra på detta är att den kan upprepa robot-programmet flera gånger när det har blivit skrivet. Detta gör att man kan programmera roboten en gång för en arbetsuppgiftAdvanced manufacturing technologies and programmable machines such as industrial robots are used to increase productivity and quality for competitiveness on a global market. Development of increasingly flexible manufacturing systems has resulted in an increasing importance of software aspects, both on a system level and for efficient interaction with human operators. Trends toward providing custom

Uppåkra in the Viking Age

Short review of an Iron Age Central Place in South Sweden. The place is rich in Viking Age material and is probably a predecessor of the Medieval town of Lund.