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Product-service systems: Panacea or myth?

Popular Abstract in Swedish Dagens storskaliga tillverkning baseras på varor med relativt kort livstid och lågt pris. Vinsterna för tillverkarna kommer från den stora mängden sålda varor. Det finns dock inom många industribranscher krympande vinstmarginaler och många företag söker därför efter nya källor för att uppnå bättre rörelseresultat. Även miljöfrågorna är en utmaning för industrin. VäxandeLife cycle environmental problems have been addressed by a number of strategies. However, the results are mostly lamentable because solutions are searched for within the same paradigms that give rise to the problems. This research questions the vision of linear material growth and searches for ways to sustain economic growth without putting the natural environment under stress. The research explor

Bacterial virulence in urinary tract infection

Bacteriuria is associated with acute disease conditions of varying severity.48 and 62 Consequently, the definition of bacterial virulence for the urinary tract depends on the end-point chosen. Acute pyelonephritis is characterized by fever, flank pain, and general malaise. Laboratory findings include pyuria (leukocytes in the urine), elevated acute phase reactants in serum (C reactive protein [CRP

Article 31

Article 31 remains a vital provision of the 1951 Convention as much as an uneasy compromise. It is a rather complex provision affecting a much broader range of issues than the criminalization of immigration infractions and detention. Due to the difference between contemporary migratory realities and those of the drafting period, it is not straightforwardly applied. Resort to the travaux préparatoi

Non-exacerbating patients with COPD from a UK perspective using the galaxy model

Introduction: Dual bronchodilators are recommended as maintenance treatment for patients with symptomatic COPD in the UK; further evidence is needed to evaluate cost-effectiveness versus monotherapy. Cost-effectiveness of umeclidinium/vilanterol versus umeclidinium and salmeterol from a UK healthcare perspective in patients without exacerbations in the previous year was assessed using post hoc EMA

Identifying bacteria using DNA binding maps

We have developed an assay, based on nanofluidic channels and fluorescence microscopy, for optical mapping of DNA based on competitive binding between two molecules - one fluorescent and one sequence selective. From the experimental data we can extract binding constants for the two competing DNA binders, which may be subsequently used to calculate a theoretical reference map of any DNA with known

Outpatient volumes and medical staffing resources as predictors for continuity of follow-up care during transfer of adolescents with congenital heart disease

Background: Providing continuous follow-up care to patients with congenital heart disease (CHD) remains a challenge in many settings. Previous studies highlight that patients with CHD experience discontinuation of follow-up care, but mainly describe a single-centre perspective, neglecting inter-institutional variations. Hospital-related factors above and beyond patient-related factors are believed

Beta secretase 1-dependent amyloid precursor protein processing promotes excessive vascular sprouting through NOTCH3 signalling

Amyloid beta peptides (Aβ) proteins play a key role in vascular pathology in Alzheimer’s Disease (AD) including impairment of the blood–brain barrier and aberrant angiogenesis. Although previous work has demonstrated a pro-angiogenic role of Aβ, the exact mechanisms by which amyloid precursor protein (APP) processing and endothelial angiogenic signalling cascades interact in AD remain a largely un