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Observations based on overexpression of the suppressor gene p53 or interference with endogenous p53 support a role for p53 in mediating not only growth inhibition and apoptosis but also differentiation. The aim of this study was to characterize the mechanisms of p53-dependent differentiation in the monoblastic leukemia cell line U-937. These cells were transfected with a mutant of the p53 gene exp

Background: To show results of a prespecified pooled analysis of the studies SPORTIF III (open-label) and SPORTIF V (double-blind), to assess the homogeneity of the results and to explore subgroup analyses and adverse events. Methods and Results: 7,329 patients with atrial fibrillation (AF) and 1 additional stroke risk factor were randomized to warfarin (international normalized ratio 2.0-3.0) or

A cysteine proteinase of 30 kDa (CP30) of Trichomonas vaginalis, is known to play a role in cytoadherence of the parasite to host cells. However, the CP30 activity in clinical isolates from symptomatic and asymptomatic patients has not been analyzed. In the present study, CP30 was detected in 20 fresh and long-term culture maintained T. vaginalis isolates each from symptomatic and asymptomatic wom

Varje medlemsstat har förbehållit sig rätten att lagstifta inom rättsområdet direkt beskattning. Det medför att medlemsstaterna är skatterättsligt suveräna och att gemensamma EU-beslut kan fattas inom detta rättsområde, under särskilda omständigheter. Trots detta har EU-domstolen sedan ca 30 år tillbaka, avkunnat domar som berör frågor huruvida regler inom den direkta beskattningens område är föreOver the years it has become clear that the Court of Justice of the European Union may, despite the principle of fiscal sovereignty rule on the compatibility of domestic tax measures belonging to the field of direct taxation, with the fundamental freedoms. Truthfully, the compatibility assessment is found much earlier in other fields of law. The last step of the methodology used by the Court encom

Examensarbetets titel: Från buzzword till sanning? Seminariedatum: 2014-06-05 Ämne/kurs: FEKH29, Examensarbete i marknadsföring på kandidatnivå, 15HP Författare: Jeanna Lundberg och Julia Undin Handledare: Jon Bertilsson Fem nyckelord: buzzword, fad, svenska reklambranschen, content marketing, fäste Syfte: Att förbättra tidigare kunskap om hur reklambyråer i Sverige hanterar samt förhåller siTitle: From buzzword to truth? Seminar date: 2014-06-05 Course: FEKH29, Bahelor Thesis in Business Administration, specialization in marketing, Undergraduate level, 15ECTS Authors: Jeanna Lundberg and Julia Undin Advisor: Jon Bertilsson Key words: buzzword, fad, the Swedish advertising business, content marketing, attachment Purpose: Improving prior knowledge of how advertising agencies in S

“What discrepancies arise from the incompatible definitions of intangibles for transfer pricing purposes according to the OECD Transfer Pricing Guidelines 2017 and the U.S. Tax Cuts and Jobs Act, and what are the risks?” The thesis analyses the discrepancies of the different definitions of intangibles in a transfer pricing context, between the OECD Transfer Pricing Guidelines 2017 and the U.S. ta

Lag om anställningsskyddslag är den lag som skyddar arbetstagare vid uppsägningar och avskedanden. Denna svenska lagstiftning finner vi i LAS som är från år 1974 men kom sedan att ändras år 1982. I 7 § andra stycket LAS stadgas omplaceringsreglerna som reglerar arbetsgivarens skyldighet att försöka bereda annat arbete hos sig. Uppsägningen från arbetsgivaren ska vara sakligt grundad. Innan arbetsgThe Employment Protection Act, LAS, is the law that protects workers in the event of dismissal and termination. This Swedish legislation can be found in LAS which is from 1974 but changed in 1982. Section 7, second paragraph in LAS, stipulates the relocation rules that regulate the employer's obligation to try to prepare other work with him. The dismissal from the employer must be objective gr

This bachelor’s thesis aims to analyze and compare how two contemporary theologians, Roger Haight, S.J. and Ted Peters, understand the genesis of the faith in Jesus’ resurrection and its significance for the Christian understanding of Jesus from Nazareth. In order to fulfill this aim, I have mainly studied Jesus: Symbol of God and Ted Peters’ God – The World’s Future. From this inquiry, I firstly

The purpose of this study was to analyze selected passages of the short story The South Wind by the Iraqi writer Abd el-Malik Nuri, which was done in order to find out how the description of characters, setting, and events, are related to class. The main research questions dealt with how the use of word choice and imagery are used in connection to the setting and characterization, but also how the

In the following Master’s thesis I examine two central concepts in the development of the Latin-American novel of the 20th century: the Marvelous Real (lo real maravilloso) and the American Baroque (lo barroco americano), both developed by the Cuban author Alejo Carpentier (1904-1980). In the study, following some biographical considerations, two original texts by Carpentier are presented; the fir

Fiberförstärkta plastkonstruktioners inverkan på risknivå ombord på stora passagerarfartyg Användning av fiberförstärkta plastkonstruktioner (FRP) inom den marina sektorn har blivit alltmer intressant ur ett hållbarhetsperspektiv. Problemet med FRP som byggnadsmaterial är att det är brännbart, vilket på grund av tradition och reglering gör det svårt att övergå från, det mer traditionella materialeThe main objective of this project was to determine how a FRP composite structure performs compared to a steel structure in regard to fire safety and risk level during an evacuation. More specifically the objective was to study how the differences in the thermal properties influence the smoke layer height, visibility and the temperature of the gases in the early stages of a fire. This was done by

In this paper I discuss the compatibility of externalism about epistemic justification with the well-known KK-thesis in epistemic logic. A weaker form of the KK-thesis (if one knows, one is also in a position to know that one knows) is first defended against Williamson's anti-luminosity arguments. Given some base assumptions about the nature of human beings and states of knowing, it is argued

Darfurkonflikten är en av de mest våldsamma och brutala konflikter som har präglat 2000-talet. Vad som har orsakat konflikten är en fråga som har delat den akademiska världen i två tydliga läger, ett som argumenterar för att klimatförändringarna är den primära orsaken till konflikten. Medan andra hävdar att politiska beslut ligger bakom det hatt och splittringar som har präglat konflikten. SamtidiThe Darfur conflict is one of the most violent and brutal conflicts during the 21st century. There is still an ongoing debate over the cause of the conflict that has split the academic world in primarily two different camps. One that argues that climate change is the primary cause of the conflict, and another that argues that political decisions are the main factor for the conflict. At the same ti

Denna kandidatuppsats undersöker en direkt aktion mot brännvinsbrännerier som genomfördes i Karlshamn, november 1853. Den arbetande befolkningen i staden var vid denna tid mycket upprörda över det faktum att de lokala brännvinsbrännerierna fick fortsätta att köpa upp och bränna spannmål och potatis, trots den ständigt ökande bristen på livsmedel. Genom att tillämpa den brittiske historiken E.P. ThThis thesis aims to investigate a case of worker’s direct action against distilleries of hard liquor (brännvin) in the southern Swedish town of Karlshamn, November 1853. Many people were angry because the distilleries were allowed to keep on distilling grains and potatoes despite the constantly increasing shortage of basic foodstuffs. By applying English historian E.P. Thompson’s theory of “the mo

Den juridiska frågan om i vilken utsträckning stater får tvångsrädda människor på internationellt vatten, har fått ny betydelse i och med migrationsflödet över centrala Medelhavet. Flera incidenter har visat att det finns såväl strategiska som rent överlevnadsbaserade grunder till att migranter och flyktingar motsätter sig räddning av vissa statsfartyg på Medelhavet. Denna uppsats syftar till att The legal question of State’s use of forcible measures to rescue people on international water has gained relevance in relation to the current migratory movements on the Mediterranean Sea. Multiple incidents have shown that there are strategic as well as pure survival motives for a migrant boat to refuse assistance. The aim of this thesis is to investigate to what extent States may use forcible me