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The interrogative model of inquiry and inquiry learning

Hakkarainen and Sintonen (2002) praise the descriptive adequacy of Hintikka's Interrogative Model of Inquiry (imi) to describe children's practices in an inquiry-based learning context. They further propose to use the imi as a starting point for developing new pedagogical methods and designing new didactic tools. We assess this proposal in the light of the formal results that in the imi characteri

Mucosal receptors involved in pathogen recognition and host defence

Urinary tract infection is the most common infection in man. P fimbriae are virulence factors of uro-pathogenic Escherichia coli. They are expressed by 70-90 % of acute pyelonephritis isolates and up to 100% of the most virulent isolates that cause bacteremia. This thesis concerns the interaction between P fimbriae and the urinary tract mucosa, and the host receptors involved in fimbrial recognit

Evaluating the Machinability of Inconel 718 Using Polar Diagrams

Abstract in UndeterminedThe use of a polar diagram method for describing and evaluating the machinability ofInconel 718 was explored. Five key parameters of the work material, representing themechanical and physical properties, which have the strongest influence on its machinability,were employed in the diagrams. These five parameters were integrated into asingle polar diagram, used to describe th

1H NMR diffusometry study of water in casein dispersions and gels

The self-diffusion coefficients of water in casein solutions and gels were measured using a pulsed-gradient spin-echo nuclear magnetic resonance technique (PGSE NMR). The dependence of the self-diffusion coefficient of water on the concentration and structure-of casein is reported. The results were analyzed using a cell model. It was found that the water self-diffusion coefficient is insensitive t

Lipids as cofactors in protein folding: Stereo-specific lipid-protein interactions are required to form HAMLET (human alpha-lactalbumin made lethal to tumor cells).

Proteins can adjust their structure and function in response to shifting environments. Functional diversity is created not only by the sequence but by changes in tertiary structure. Here we present evidence that lipid cofactors may enable otherwise unstable protein folding variants to maintain their conformation and to form novel, biologically active complexes. We have identified unsaturated C18 f

T cell surface redox levels determine T cell reactivity and arthritis susceptibility.

Rats and mice with a lower capacity to produce reactive oxygen species (ROS) because of allelic polymorphisms in the Ncf1 gene (which encodes neutrophil cytosolic factor 1) are more susceptible to develop severe arthritis. These data suggest that ROS are involved in regulating the immune response. We now show that the lower capacity to produce ROS is associated with an increased number of reduced

Apical sorting by galectin-3-dependent glycoprotein clustering

Epithelial cells are characterized by their polarized organization based on an apical membrane that is separated from the basolateral membrane domain by tight junctions. Maintenance of this morphology is guaranteed by highly specific sorting machinery that separates lipids and proteins into different carrier populations for the apical or basolateral cell surface. Lipid-raft-independent apical carr

Strategies Applied by Women in Coping With ad-hoc Demands for Unauthorized User Fees During Pregnancy and Childbirth. A Focus Group Study From Angola.

Our aim in this study was to explore women's responses to reported ad-hoc demands for unauthorized user fees during pregnancy and childbirth in Luanda, Angola. Ten focus group discussions were conducted and data were analysed using grounded theory. Women were found to apply six strategies as they "endeavored to cope with demands for unauthorized user fees" (core category): (i) blowing the whistle,

As though we had no spirit: Ritual, politics and existence in the Aymara quest for decolonization

Colonialism’ and ‘decolonization’ have been dealt with by postcolonial studies and, more recently, by scholars identified with the ‘de-colonial turn’. At the same time, in the ethnopolitically charged context of contemporary Bolivian society, colonialism and decolonization have become issues of political, existential and even cosmological import. This thesis identifies a need to root the ‘de-colon

Higher Education: Commodity or Space for Learning: modelling contradictions in educational practices

In this article the authors reflect upon and critically examine signs of a contradiction in higher education which they discuss in terms of the tension between 'use value' and 'exchange value'. Use value here represents learning as something valuable ‘in itself’ whereas exchange value represents learning as an achievement of grades and credits to be ‘traded’ on a market. Their aim in this article

Cytokine levels in the blood may distinguish suicide attempters from depressed patients.

Elevated plasma cytokines is a common finding in Major Depressive Disorder (MDD), although not consistent. It is currently not known whether the inflammatory changes are confined to any specific subgroup of depressive patients. We here analyzed three inflammatory markers in suicidal and non-suicidal depressive patients, as well as healthy controls. Plasma interleukin (IL)-2, IL-6 and tumor necrosi

Colloidal systems in DNA packaging

The interaction between DNA and cationic cosolutes- multivalent ions, cationic surfactants and cationic macromolecules- has direct biological implications and is also foreseen to have a number of applications, in particular for transfection and protection and purification of DNA. We have during the last few years established a broad physico-chemical research program on various mixed systems of DNA