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Superantigens (SAgs) are bacterial enterotoxins produced by Staphylococcus aureus. Staphylococcal enterotoxin type A (SEA), a staphylococcal superantigen, has been shown to bind to the cytokine signalling receptor glycoprotein 130 (gp130). The structural details, as well as the exact physiological role of this interaction, remain unclear. Here, we describe the structural details of the SEA–gp130 c

We show that the category of finitely generated free modules over certain local rings is 𝑛-angulated for every 𝑛⩾3. In fact, we construct several classes of 𝑛-angles, parameterized by equivalence classes of units in the local rings. Finally, we show that for odd values of 𝑛 some of these 𝑛-angulated categories are not algebraic.

In this chapter we introduce biomaterials science to a nonexpert reader in order to provide new perspectives for the development of in vitro three-dimensional models that are relevant in lung research. Specifically, we provide a comprehensive description of key concepts in the fields of biomaterials science and lung research to explain how merging them can give rise to new models of lung biology a

The tumor suppressor gene p53 can mediate both apoptosis and cell cycle arrest. In addition, p53 also influences differentiation. To further characterize the differentiation inducing properties of p53, we overexpressed a temperature-inducible p53 mutant (ptsp53Val135) in the erythroleukemia cell line K562. The results show that wild-type p53 and hemin synergistically induce erythroid differentiati

This brief overview of the use of household salt (NaCl) in optically stimulated luminescence (OSL) dosimetry is focusing on the use of NaCl pellets. It is suggested that the most optimal use of household NaCl, in general prospective dosimetry, is to compress the salt grains to pellets and read the radiation induced signal using OSL rather than TL. A summary of the main OSL dosimetric properties is

We present an overview of the 4MOST project at the Preliminary Design Review. 4MOST is a major new wide-field, high-multiplex spectroscopic survey facility under development for the VISTA telescope of ESO. 4MOST has a broad range of science goals ranging from Galactic Archaeology and stellar physics to the high-energy physics, galaxy evolution, and cosmology. Starting in 2021, 4MOST will deploy 24

Homelessness is a growing global problem. Homelessness produces and reinforces social exclusion. The main reason for homelessness is that there is a shortage of housing available to people with low incomes. Counteracting homelessness requires housing policy initiatives that make it possible for people with low incomes to have access to housing. At the same time people who are homeless must receive

BACKGROUND AND AIM: The drinking water in parts of Ronneby municipality was heavily contaminated with perfluoroalkyl substances (PFAS) for decades. Although PFAS has endocrine-disrupting properties and may interfere with breastfeeding, the supporting epidemiologic literature is conflicting and based solely on populations with background levels of exposure. The effects on breastfeeding in populatio

Understanding how innovation comes about is essential to furthering economic development and sustainable transitions. Noting “creative response” (Schumpeter, 1947) as a broad notion of how agents respond to changes in their environment, this lemma surveys main contributions to our understanding of innovation as endogenous to social and economic mechanisms. Through a review of economic historical d

Objectives: An increased interest in the phenomenon and process of compassion, in both clinical and non-clinical psychological research, has been seen in recent decades. In these contexts, compassion is frequently understood as a felt response to the suffering of others that involves caring and seeing the universal nature of human suffering, as well as an authentic desire to ease the distress. Bas