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BACKGROUND: The disabilities of the arm, shoulder and hand (DASH) questionnaire is a self-administered region-specific outcome instrument developed as a measure of self-rated upper-extremity disability and symptoms. The DASH consists mainly of a 30-item disability/symptom scale, scored 0 (no disability) to 100. The main purpose of this study was to assess the longitudinal construct validity of the
Popular Abstract in Swedish Avhandlingen består av tre empiriska uppsatser inom internationell finansiell ekonomi. Den ekonometriska gemensamma nämnaren är att samtliga använda modeller är av komplex multivariat natur. Därför föreslås att de ekonometriska modellerna estimeras med hjälp av simulated annealing, en stokastisk optimeringsalgoritm som potentiellt löser de problem som vanligtvis är förkThis thesis consists of three self-contained empirical studies on international financial economics. The common economic theme is that all three studies deal with international stock market return and risk. The common econometric theme is that all estimations are performed using simulated annealing, a stochastic optimization algorithm in the Markov Chain Monte Carlo family, in an attempt to solve
Plasmodium falciparum is the causative agent of the most severe type of malaria, a life-threatening disease affecting the lives of over three billion people. Factors like widespread resistance against available drugs and absence of an effective vaccine are seriously compounding control of the malaria parasite. Thus, there is an urgent need for the identification and validation of new drug targets.
Introduction: Biokinetic and dosimetry studies in small animals often precede clinical radionuclide therapies. As in human studies, a reliable evaluation of therapeutic efficacy is essential and must be based on accurate dosimetry, which must be based on a realistic dosimetry model. The aim of this study was to evaluate the differences in the results when using a more anatomic realistic mouse phan
This study was performed to investigate the mechanisms responsible for the transport of albumin and low-density lipoprotein (LDL) across capillary walls in vivo. To separate transcytosis from passive, 'porous' transport, we tested the effects of the transcytosis inhibitors N-ethylmaleimide (NEM) and filipin given intraperitoneally on the peritoneal capillary clearance of LDL and albumin in anesthe
Objective: Valid dietary data are essential when trying to identify whether or not one or more dietary exposures are responsible for disease. We examined diet composition in women who reported dietary change in the past compared with non-changers, and how the associations between dietary factors and postmenopausal breast cancer are influenced by dietary change, obesity status and misreporting of e
The laser-induced incandescence technique (LII) is a laser-based diagnostic technique for measurements of soot volume fraction and particle size. The technique relies on detection of incandescent light from soot particles heated to around 4000 K using nanosecond laser pulses. A theoretical model for LII has been implemented and improved in order to provide a tool for predicting the signal respons
The aim of the present study was to take a closer look into the evidence for a theory of prehistoric string manufacture, formulated by the British archaeologist Karen Hardy in the article Prehistoric string theory. How twisted fibers helped to shape the world (Hardy, 2008). A problem with the article, with the relevance and validity of the presented evidence as substance for the theory, was the mi
Recent trends of permafrost thawing in the subarctic are expected to cause increased release of dissolved organic carbon (DOC) to inland waters, which might have cascading effects on downstream aquatic ecosystems and release of CO2 to the atmosphere. This study therefore aimed at evaluating the applicability of an empirical band ratio algorithm for estimating chromophoric dissolved organic matter
We test a new approach to calculate the mean velocity and velocity dispersion for a sample of nearby stars when their radial velocities are not available. The most commonly used method (here called the projection method, PM) was introduced in a paper by Dehnen & Binney (1998). That method is here compared, theoretically and numerically, with an application of the Maximum Likelihood (ML) method
This paper focuses on the stratification within the education systems of the social-democratic welfare regime. Since 1990 the welfare states and education systems of Denmark, Finland, Norway Sweden has changed significantly. At the same time there has been a decrease in the power of the working class and its allies. According to the Power Resource Theory this should, at least eventually, lead to a
Monte Carlo simulation is frequently employed to compute p-values for test statistics with unknown null distributions. However, the computations can be exceedingly time-consuming, and, in such cases, the use of pre-computed simulations can be considered to increase speed. This approach is attractive in principle, but complicated in practice because the size of the pre-computed data can be prohibit
Background: Dystroglycan (Dg) is a transmembrane protein that is a part of the Dystrophin Glycoprotein Complex (DGC) which connects the extracellular matrix to the actin cytoskeleton. The C-terminal end of Dg contains a number of putative SH3, SH2 and WW domain binding sites. The most C-terminal PPXY motif has been established as a binding site for Dystrophin (Dys) WW-domain. However, our previous
