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There is a global demand for sustainable industrial development and a call to make manufacturing “greener”. Nanotechnologies are in a promising position to be early adopters of this concept. Advancements in the nanomaterial industry can help confront global issues, and aid in sustainable development that enables positive economic, environmental, and social changes. Formal evaluation of a product’s
The Nucleosome Remodeling and Deacetylase (NuRD) complex is a transcriptional regulator essential to several normal developmental processes, but also found to have a role in several types of cancer. In order to design cancer therapies targeting this complex, determining the structure and subunit composition is crucial. X-ray crystallography is required for the level of detail desired, demanding la
This is a representation study of the antagonist character and monstrous female vampire Drusilla from the TV-show ”Buffy the Vampire Slayer” (1997). The purpose of this study is to find out how Drusilla as an antagonist is portrayed from a feministic perspective. The theories that are used focus on monstrous female, sex, motherhood and female objectification in TV, film and literature. Using these
Female drivers operating in the public transport sector are underrepresented in the literature on women’s mobility which largely addresses the fear of crime among female riders. Alternative modes of transport, as well as job opportunities, have nevertheless started to emerge as international and local ride-hailing firms mushroom across the globe in urban cities. The World Bank Group International
The global transport industry stands in front of the next big technology shift; the implementation of autonomous vehicles. This shift might remove the physical driver from the truck, increase safety and improve flexibility. This will most likely change the fundamentals of the transportation industry. Autonomous trucks are anticipated to be implemented for short distance transportation in gated are
Efforts to reform the public sectors of Zambia have been ongoing since the 1990s with objectives to ensure efficient and high-quality provision of public goods and services to all citizens and battling persistently high levels of poverty. Outcomes have however been mixed at best. This study assesses how reforms to the public sectors of Zambia have been framed in terms of what problem representati
Wetland and biodiversity loss affect both ecosystem function and human wellbeing. However, it is argued that the incremental rate of farmland abandonment provides opportunities for ecological restoration to help reverse this negative trend. This thesis applies ecosystem service framework and psychological ownership theory to analyse a wetland restoration project in a semi-urban town of Jablonné v
A translocation between chromosomes 9 and 22 produces the fusion gene BCR-ABL that leads to the constitutive activity of a tyrosine kinase. This initiates the uncontrolled proliferation of myeloid cells causing Chronic Myeloid Leukaemia (CML). The disorder is treated by tyrosine kinase inhibitors (TKIs) that prevent the progression of CML into more advanced phases. The treatment must be sustained
The invention of the integrated circuit is a key milestone in the history of electronic circuits. Since its introduction the number of components on a chip have increased rapidly, making them more powerful and able to perform complex operations, but it has also changed the design process. Today different parts of a chip can be developed separately as Intellectual Property (IP) and then put togethe
Background: Cancer of unknown primary (CUP) is a fatal cancer, accounting for 3-5% of all diagnosed cancers. Finding the primary site is important for therapeutic choices and we believe that the organ which is designated as the cause of death may give clues about the primary site. Methods: A total of 20,570 patients with CUP were identified from the Swedish Family-Cancer Database. Causes of death
A simple, rapid and environmentally friendly hollow-fibre liquid-phase microextraction (HF-LPME) technique was developed for the quantitative determination of polycyclic aromatic hydrocarbons (PAHs) in aqueous samples. GC-MS was then used as the method of analysis. The HF-LPME technique involves extraction of PAHs from a 20-mL sample containing 20 % acetonitrile as a modifier. The PAHs were extrac
The duration of cell death may allow deducing the underlying degenerative mechanism. To find out how long a photoreceptor takes to die, we used the rdl mouse model for retinal neurodegeneration, which is characterized by phosphodiesterase-6 (PDE6) dysfunction and photoreceptor death triggered by high cGMP levels. Based on cellular data on the progression of cGMP accumulation, cell death, and survi
Monte Carlo simulation is frequently employed to compute p-values for test statistics with unknown null distributions. However, the computations can be exceedingly time-consuming, and, in such cases, the use of pre-computed simulations can be considered to increase speed. This approach is attractive in principle, but complicated in practice because the size of the pre-computed data can be prohibit
Background: Dystroglycan (Dg) is a transmembrane protein that is a part of the Dystrophin Glycoprotein Complex (DGC) which connects the extracellular matrix to the actin cytoskeleton. The C-terminal end of Dg contains a number of putative SH3, SH2 and WW domain binding sites. The most C-terminal PPXY motif has been established as a binding site for Dystrophin (Dys) WW-domain. However, our previous
Amplitudes, rates, periodicities, causes and future trends of temperature variations based on tree rings for the past 2485 years on the central-eastern Tibetan Plateau were analyzed. The results showed that extreme climatic events on the Plateau, such as the Medieval Warm Period, Little Ice Age and 20th Century Warming appeared synchronously with those in other places worldwide. The largest amplit
New metastable massive particles with electric and colour charge are features of many theories beyond the Standard Model. A search is performed for long-lived gluino-based R-hadrons with the ATLAS detector at the LHC using a data sample corresponding to an integrated luminosity of 31 pb(-1). We search for evidence of particles that have come to rest in the ATLAS detector and decay at some later ti
BACKGROUND: Family members of persons with pre-dialysis chronic kidney disease may experience feelings of vulnerability and insecurity as the disease follows its course. Against this background, the aim of the present study was to explore empowerment in outpatient care as experienced by these family members. METHODS: An inductive approach for qualitative data analysis was chosen. The study sampl
Popular Abstract in Swedish Trots utvecklingen inom materialvetenskap, datorkapacitet och byggnadsteknik, fortsätter fel relaterade till byggnadsfysik att inträffa i våra byggnader. Dessa byggnadsfel spänner mellan att byggnader inte möter kraven på energianvändning till att byggnader orsakar hälsoproblem hos de människor som vistas i byggnaden till följd av att de utsätts för kemikalier eller bioDespite advances in material science, computers and building technology, building failures related to building physics continue to occur. These failures range from a building not meeting its energy use target to a building causing people to become ill from exposure to various chemicals or biological organisms. These failures cost society considerable amounts of money each year and many of these fa
We present a novel design for a macrostructured cathode that can be coated with a thin layer of the B-10 solid converter and mounted to replace the Boron-lined flat parallel plates of a proportional counter used for slow neutron detection. The proposed design consists of a 3D regular pattern exhibiting millimeter deep grooves with an opening angle of alpha = 45 degrees, which could be created in t
