Sökresultat

Plasmodium falciparum is the causative agent of the most severe type of malaria, a life-threatening disease affecting the lives of over three billion people. Factors like widespread resistance against available drugs and absence of an effective vaccine are seriously compounding control of the malaria parasite. Thus, there is an urgent need for the identification and validation of new drug targets.

Introduction: Biokinetic and dosimetry studies in small animals often precede clinical radionuclide therapies. As in human studies, a reliable evaluation of therapeutic efficacy is essential and must be based on accurate dosimetry, which must be based on a realistic dosimetry model. The aim of this study was to evaluate the differences in the results when using a more anatomic realistic mouse phan

This study was performed to investigate the mechanisms responsible for the transport of albumin and low-density lipoprotein (LDL) across capillary walls in vivo. To separate transcytosis from passive, 'porous' transport, we tested the effects of the transcytosis inhibitors N-ethylmaleimide (NEM) and filipin given intraperitoneally on the peritoneal capillary clearance of LDL and albumin in anesthe

Objective: Valid dietary data are essential when trying to identify whether or not one or more dietary exposures are responsible for disease. We examined diet composition in women who reported dietary change in the past compared with non-changers, and how the associations between dietary factors and postmenopausal breast cancer are influenced by dietary change, obesity status and misreporting of e

The laser-induced incandescence technique (LII) is a laser-based diagnostic technique for measurements of soot volume fraction and particle size. The technique relies on detection of incandescent light from soot particles heated to around 4000 K using nanosecond laser pulses. A theoretical model for LII has been implemented and improved in order to provide a tool for predicting the signal respons

This paper includes species investigated through many years starting with original material from museum collections. A great number of species in the genera Stephanodiscus Ehrenberg, Cyclostephanos Round and Cyclotella (Kutzing) Brebisson, all in the family Stephanodiscaceae Makarova, are presented with holo-, lecto- and/or neotypes, type locality and information concerning nomenclature. A typus g

Maturity-onset diabetes of the young (MODY) is a heterogeneous single gene disorder characterized by non–insulin-dependent diabetes, an early onset and autosomal dominant inheritance. Mutations in six genes have been shown to cause MODY. Approximately 15–20% of families fitting MODY criteria do not have mutations in any of the known genes. These families provide a rich resource for the identificat

An analytical procedure based on microwave-assisted extraction (MAE) and standard addition was applied for the determination of banned azo dyes in bovine, sheep, and goat leather. Standard addition at four different concentration levels was performed using azo dyes, dissolved either in methanol or water. All dyes were determined indirectly by measuring their corresponding harmful aromatic amines,

We have investigated the electron transfer from reduced tyrosine YD (YDred) and cytochrome b559 to the S2 and S3 states of the water oxidizing complex (WOC) in Photosystem II. The EPR signal of oxidized cyt b559, the S2 state multiline EPR signal and the EPR signal from YD@? were measured to follow the electron transfer to the S2 and S3 states at 245 and 275 K. The majority of the S2 centers was r

Methods of analysing and interpreting two-dimensional velocity field data in order to understand the scales of turbulence of bubbly two-phase flow were developed. Reynolds decomposition and large eddy simulation (LES) decompositions (low-pass filtering), in conjunction with proper orthogonal decomposition (POD) energy spectra analysis, as well as adjusted convective decomposition (constant convect

The thesis uses, as a starting point for a discussion of emergency response management, the problem of gradual coordinated adaptation of management functions in relation to an event and its dynamics. Empirical observations and analyses carried out in the research project show that important problemsolving processes not included in, and sometimes diverging from, planning and preparations frequently

The aim of this paper is to explore relations between science and the public. Specifically, Swedish meteorology around 1900 and the role of media relations in the construction of a storm-warning system will be discussed. It is argued that science - public interaction can be a factor in the process of establishing priorities in science.

More and more people are moving to urban areas, but with this urban growth, there is also an increase in the urban population coping with health problems. This thesis explores the possibilities of restoring mental health through Urban Design. This is done by creating a vision plan for a restorative neighbourhood in Antwerp, named 'Het Eilandje'.

The unicellular green alga of genus Chlamydomonas are well studied within the fields of photosynthesis and flagellar research. Although many molecular tools have been developed for use on Chlamydomonas, little research has been done on its ecology and population dynamics. Species within the genus are morphologically indistinguishable using light microscopy and as such a molecular method is necessa