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Background: Admission lactate and lactate clearance are implemented for risk stratification in sepsis and trauma. In out-of-hospital cardiac arrest, results regarding outcome and lactate are conflicting. Methods: This is a post-hoc analysis of the Target Temperature Management trial in which 950 unconscious patents after out-of-hospital cardiac arrest were randomized to a temperature intervention

Human C4b-binding protein (C4BP) is a soluble, multiple-subunit inhibitor of complement that circulates in blood. Recently C4BP was shown to bind DNA, reduce DNA release from necrotic cells and limit DNA-mediated complement activation in solution. Herein we employed nuclear magnetic resonance spectroscopy to measure chemical shift perturbations and used them to restrain the computational docking o

It is widely believed that DC, but not macrophages, prime naïve T cells in vivo. Here, we investigated the ability of CD68-expressing cells (commonly defined as macrophages) in priming autoreactive T cells and initiating collagen-induced arthritis (CIA) in the mouse. For this purpose, a transgenic mouse was developed (MBQ mouse) where macrophages exclusively expressed the MHC class II H2-A(q) (A(q

The existence of T cells restricted for the MHC I-like molecule CD1 is well established, but the function of these cells is still obscure; one implication is that CD1-dependent T cells regulate autoimmunity. In this study, we investigate their role in experimental autoimmune encephalomyelitis (EAE), an animal model for multiple sclerosis, using CD1-deficient mice on a C57BL/6 background. We show t

The function of the nucleolus is intimately connected to cell proliferation, division and growth. Many cancer cells have enlarged nucleoli, and several nucleolar proteins have been linked to tumorigenesis. In order to find proteins whose expression is altered in the nucleoli of leukemic cells, we carried out two-dimensional difference gel electrophoresis (2-D DIGE) analyses. Prohibitin (PHB) and T

Abstract Aims Myelinated nerve fibre pathology has been demonstrated at wrist level in diabetic patients. We examined if quantification of intra-epidermal nerve fibre density (IENFD) in hairy and glabrous skin at wrist level could detect signs of subclinical small nerve fibre neuropathy. Methods In 35 diabetic patients who were age and gender matched with 31 non-diabetic patients, punch biopsies w

The project “3D-Digging at Çatalhöyük” began in 2010 thanks to collaboration between Stanford University (Archaeological Center) and the University of California Merced with the scope to record, document (with different digital technologies) and visualize in virtual reality all the phases of archaeological excavation. Phase I (2010 excavation season) of the project was mainly oriented to test diff

GPUs in embedded platforms are reaching performance levels comparable to desktop hardware, thus it becomes interesting to apply Computer Vision techniques. We propose, implement, and evaluate a novel feature detector and descriptor combination, i.e., we combine the Harris-Hessian detector with the FREAK binary descriptor. The implementation is done in OpenCL, and we evaluate the execution time and

Sequencing of immunoglobulin germline gene loci is a challenging process, e.g. due to their repetitiveness and complexity, hence limiting the insight in the germline gene repertoire of humans and other species. Through next generation sequencing technology, it is possible to generate immunoglobulin transcript data sets large enough to computationally infer the germline genes from which the transcr

Environmental, social and governance (ESG) issues are driving corporate strategy and performance. However, does this mean more ESG reporting is being done? If so, is the quality of ESG reports improving? And what about ESG performance? In this paper, we examine these three trends in ESG reporting—quantity, quality and corporate ESG performance. With a Swedish multinational corporate focus, we anal

This chapter argues for a new listening practice for electroacoustic music (EAM) that I call “deep situated listening”. “Deep situated listening” builds on existing EAM-theories, aesthetics and practices – which I here collectively refer to as the “hearing heads” approach – but extends this approach by adding an explicitly feminist perspective. “Deep situated listening” combines Donna Haraway’s no

Searches for extra dimensions have been made at the four LEP experiments, ALEPH, DELPHI, L3 and OPAL, where different processes have been searched for within both the ADD and Randall-Sundrum scenarios. Since no signs of any signal have been observed the results have been used to set exclusion limits in the corresponding extra dimension models. This talk presents both individual results from the LE

At a large tunnel project in Southern Sweden a number of geoelectrical and IP imaging were carried out. The tunnel is drilled through a horst with a complex geology which includes fractures, high water content and weathered zones. The measurements where carried out to compile a geologic model to use in the further planning of the project. The resistivity and IP complements each other very well sin

Abstract in UndeterminedAn interlaboratory study on measurement of evaporative resistance (Ret) with thermal manikins has been conducted in order to assess the repeatability and reproducibility limits as a function of mean resistance values, when using similar test protocols (ASTM F2370). Three independent laboratories tested seven clothing ensembles, with Ret ranging from very low to very high va

Self-tuning control of the dissolved oxygen concentration has been tested in full scale at the Käppala Sewage Works at Lidingö, Sweden. The controller has been shown to be robust during varying operating conditions. It also gives the potential for the estimation of interesting variables, such as the oxygen uptake rate. A number of water quality variables have been examined. Interesting couplings b