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Development of rotational CARS for combustion diagnostics using a polarization approach

Rotational Coherent anti-Stokes Raman spectroscopy (CARS) has the last decades been developed into a useful tool for thermometry and concentration measurements in combustion. In this paper, we present a novel polarization approach of the technique, which will enhance its potential and widen the range of conditions at which it can be utilized. The theory of the polarization approach is described in

Re-organising the logistics resources of companies after mergers and acquisitions

This paper discusses the relation between logistics and Mergers and Acquisitions (M&A) of companies within the same industry and same industry level (i.e. horizontal M&A). The purpose is to study the effects of M&A on the logistics resources of companies and the possibility for companies to benefit from the re-organising of these resources in the form of synergies. The study hopes to a

Throat related symptoms and voice : development of an instrument for self assessment of throat-problems

BACKGROUND: Symptoms from throat (sensation of globus; frequent throat clearing; irritated throat) are common in patients referred to voice clinics and to ENT specialists. The relation to symptoms of voice discomfort is unclear and in some cases patients do not have voice problems at all. Instruments for patients' self-reporting of symptoms, and assessment of handicap, such as the Voice Handicap I

NLK-mediated phosphorylation of HDAC1 negatively regulates Wnt signaling

The Wnt signaling pathway is essential in regulating various cellular processes. Different mechanisms of inhibition for Wnt signaling have been proposed. Besides β-catenin degradation through the proteasome, nemo-like kinase (NLK) is another molecule that is known to negatively regulate Wnt signaling. However, the mechanism by which NLK mediates the inhibition of Wnt signaling was not known. In th

Effect of entrainment on liquid film dryout in vertical upward annular flow

This work aims to investigate the effect of liquid entrainment on liquid film dryout in annular flow for flow boiling. Entrainment and deposition rates of droplets were included in mass conservation equations to estimate the local liquid film mass flux in annular flow, and the critical vapor quality at dryout conditions. Different entrainment rate correlations were evaluated using flow boiling dat

SOX9 is a major negative regulator of cartilage vascularization, bone marrow formation and endochondral ossification

SOX9 is a transcription factor of the SRY family that regulates sex determination, cartilage development and numerous other developmental events. In the foetal growth plate, Sox9 is highly expressed in chondrocytes of the proliferating and prehypertrophic zone but declines abruptly in the hypertrophic zone, suggesting that Sox9 downregulation in hypertrophic chondrocytes might be a necessary step

Convergence Analysis of the Dirichlet-Neumann Iteration for Finite Element Discretizations

We analyze the convergence rate of the Dirichlet-Neumann iteration for the fully discretized unsteady transmission problem. Specifically, we consider the coupling of two linear heat equations on two identical non overlapping domains with jumps in the material coefficients across these. In this context, we derive the iteration matrix of the coupled problem. In the 1D case, the spectral radius of th

Tumor-directed immunotherapy can generate tumor-specific T cell responses through localized co-stimulation

The most important goals for the field of immuno-oncology are to improve the response rate and increase the number of tumor indications that respond to immunotherapy, without increasing adverse side effects. One approach to achieve these goals is to use tumor-directed immunotherapy, i.e., to focus the immune activation to the most relevant part of the immune system. This may improve anti-tumor eff

Quantitative picosecond laser-induced fluorescence measurements of nitric oxide in flames

Quantitative concentrations measurements using time-resolved laser-induced fluorescence have been demonstrated for nitric oxide (NO) in flame. Fluorescence lifetimes measured using a picosecond Nd:YAG laser and optical parametric amplifier system have been used to directly compensate the measured signal for collisional quenching and evaluate NO concentration. The full evaluation also includes the

Leukocyte telomere length predicts SSRI response in major depressive disorder : A preliminary report

Short leukocyte telomere length (LTL) may be associated with several psychiatric disorders, including major depressive disorder (MDD). Short LTL has previously been associated with poor response to psychiatric medications in bipolar disorder and schizophrenia, but no studies have prospectively assessed the relationship of LTL to SSRI response in MDD. We assessed pre-treatment LTL, depression sever

Protocol for meta-analysis of temperature reduction in animal models of cardiac arrest

Targeted temperature management (TTM) of 32-34 °C has been the standard treatment for out-of-hospital cardiac arrest since clinical trials in 2002 showed benefits to survival and neurological outcome. Recently, this treatment has been challenged by another clinical trial showing no difference in outcome between TTM of 33 °C and 36 °C. This protocol describes the methodology for a meta-analysis det

Effects on leisure activities and social participation of a case management intervention for frail older people living at home : A randomised controlled trial

Frailty causes disability and restrictions on older people's ability to engage in leisure activities and for social participation. The objective of this study was to evaluate the effects of a 1-year case management intervention for frail older people living at home in Sweden in terms of social participation and leisure activities. The study was a randomised controlled trial with repeated follow-up

Indivisible Wholes & Fragmented Realities : On the Aggregation of Disaster Risk Information

Orkanen Katrina, tsunamin i Indiska oceanen, Lehmankraschen och 11-september attackerna är bara några exempel på sentida händelser som väckt frågor kring vår förmåga att förutse och förstå katastrofrisker. I efterhand är det dock lätt att glömma att vi alltid har ett oändligt antal potentiella scenarier framför oss, men bara ett förflutet, vilket kan få oss att överdriva förutsägbarheten för händeDivision of labor and trade have been prerequisites for the development of welfare societies. Ironically, this specialization has caused a fragmentation of the knowledge necessary to understand risks that may undermine societal safety. This has not only prompted a need for inter-organizational exchange and integration of disaster risk information, it has also prompted a need for understanding how

On Human Terms – Integration of a Massive Open Online Course (MOOC) in Ergonomics in University Courses

The aim of the Massive Open Online Course (MOOC) ‘Work and Technology on Human Terms’ was to be a modern, highly accessible study material in Ergonomics/Work science to contribute to safer and healthier workplaces. The course targets engineering students, but also students in economics, human relations, physiotherapy, occupational health, as well as professionals. The purpose of this paper is to d

On Human Terms – A First Evaluation of a Massive Open Online Course (MOOC) in Ergonomics

The Massive Open Online Course (MOOC) ‘Work and Technology on Human Terms’ (www.onhumanterms.org ) was launched in July 2017 with the aim to contribute to safer and healthier workplaces by increasing the knowledge about how products, systems, and work organizations can be designed on human terms. The purpose of this paper is to present the results of a first evaluation of the MOOC. The online cour

The non-coding RNA of the multidrug resistance-linked vault particle encodes multiple regulatory small RNAs.

Vault particles are conserved organelles implicated in multidrug resistance and intracellular transport. They contain three different proteins and non-coding vault RNAs (vRNAs). Here we show that human vRNAs produce several small RNAs (svRNAs) by mechanisms different from those in the canonical microRNA (miRNA) pathway. At least one of these svRNAs, svRNAb, associates with Argonaute proteins to gu