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Dynamical modelling of globular clusters: challenges for the robust determination of IMBH candidates

The presence or absence of intermediate-mass black holes (IMBHs) at the centre of Milky Way globular clusters (GCs) is still an open question. This is due to either observational restrictions or limitations in the dynamical modelling method; in this work, we explore the latter. Using a sample of high-end Monte Carlo simulations of GCs, with and without a central IMBH, we study the limitations of s

Proposal of quality assurance system for positron emission tomography in the Russian Federation

High diagnostic efficiency as well as the optimization of patient and staff doses in positron emission tomography (PET) can be achieved by implementing quality assurance program. This study was focused on the requirements and basic aspects of quality assurance (QA) in PET combined with computed tomography (CT), that include equipment quality control (QC). QA systems include methods of image QC, ex

The incretin effect in female mice with double deletion of GLP-1 and GIP receptors

To establish the contribution of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) for the incretin effect after oral glucose, studies were undertaken in female mice with genetic deletion of receptors for GIP and GLP-1 (double incretin receptor knockout [DIRKO] mice) and their wild-type (WT) counterparts. Insulin secretion was explored after oral glucose (doses

Sequestering of damage-associated molecular patterns (DAMPs) : a possible mechanism affecting the immune-stimulating properties of aluminium adjuvants

Aluminium-based adjuvants (ABAs) have been used in human and veterinary vaccines for decades, and for a long time, the adjuvant properties were believed to be mediated by an antigen depot at the injection site, prolonging antigen exposure to the immune system. The depot hypothesis is today more or less abandoned, and instead replaced by the assumption that ABAs induce an inflammation at the inject

Agreement between artificial neural networks and experienced electrocardiographer on electrocardiographic diagnosis of healed myocardial infarction

Objectives. The purpose of this study was to compare the diagnoses of healed myocardial infarction made from the 12-lead electrocardiogram (ECG) by artificial neural networks and an experienced electrocardiographer. Background. Artificial neural networks have proved of value in pattern recognition tasks. Studies of their utility in ECG interpretation have shown performance exceeding that of conven

'May contain traces of' : An ethnographic study of eating communities and the gluten free diet

Changes to the contemporary food system, including meals and eating patterns, have occurred quickly. One such change over the past 30 years has been the increase of commercially produced foods aimed at food allergies and intolerances and ‘free from’ dieting. The gluten free diet has recently emerged as a popular diet trend in Western countries, outpacing its origins as a treatment for celiac disea

Small data and conflicting information

Things are seldom ideal. The quality in information underlying the assessment of risk and support decisions is not an exception. Quantitative measures of uncertainty are extremely useful, but a problem with quantitative measures of uncertainty is that qualitative aspects of uncertainty, e.g. related to weaknesses in background knowledge or deep uncertainty (Cox 2012), are difficult to address.

Three variants of the leukotoxin gene in human isolates of Fusobacterium necrophorum subspecies funduliforme

Leukotoxin is a well-known virulence factor of animal isolates of Fusobacterium necrophorum subspecies necrophorum, and is also expressed by animal isolates of subspecies funduliforme, whereas its presence in isolates from humans has not been fully established. In this study we found that the leukotoxin gene was present in all tested F. necrophorum isolates from humans. Three sequence variants wer

Dynamical orbital evolution scenarios of the wide-orbit eccentric planet HR 5183b

The recently discovered giant exoplanet HR5183b exists on a wide, highly eccentric orbit (a = 18 au, e = 0.84). Its host star possesses a common proper-motion companion which is likely on a bound orbit. In this paper, we explore scenarios for the excitation of the eccentricity of the planet in binary systems such as this, considering planet-planet scattering, Lidov-Kozai cycles from the binary act

Auditory hypersensitivity and attention in survivors of paediatric brain tumours

Objective: Both auditory and visual hypersensitivity are clinical features of mental fatigue after acquired brain damage or in neurological disorders. Both types of hypersensitivity are also associated with attention deficits, especially in neurodevelopmental syndromes. The aim of this study was to examine auditory and visual hypersensitivity, and associations to attention, in a group of children

Using binaries in Globular Clusters to catch sight of Intermediate-Mass Black Holes

The dynamical evolution of globular clusters (GCs) is tied to their binary population, as binaries segregate to the cluster centre, leading to an increased binary fraction in the core. This central overabundance of mainly hard binaries can serve as a source of energy for the cluster and has a significant effect on the observed kinematics, such as artificially increasing the observed line-of-sight

Are we observing an NSC in course of formation in the NGC 4654 galaxy?

We use direct N-body simulations to explore some possible scenarios for the future evolution of two massive clusters observed towards the centre of NGC 4654, a spiral galaxy with mass similar to that of the Milky Way. Using archival HST data, we obtain the photometric masses of the two clusters, M = 3 × 105 M= and M = 1.7 × 106 M=, their half-light radii, Reff ∼4 pc and Reff ∼6 pc, and their proje

Urban neighborhoods – the locus of change. What can we learn from the transition story of Augustenborg?

Cities, and more importantly urban neighborhoods, are key sites of infrastructure provision with direct links to social and environmental concerns. They are increasingly seen as sites of strategic action in transitions toward sustainability and resilience, and offer big opportunities for fundamental societal change. The framing of neighborhood-level problems and their solutions, governance process