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Combining histological grade, TILs, and the PD-1/PD-L1 pathway to identify immunogenic tumors and de-escalate radiotherapy in early breast cancer : A secondary analysis of a randomized clinical trial

Background The implementation of immunological biomarkers for radiotherapy (RT) individualization in breast cancer requires consideration of tumor-intrinsic factors. This study aimed to investigate whether the integration of histological grade, tumor-infiltrating lymphocytes (TILs), programmed cell death protein-1 (PD-1), and programmed death ligand-1 (PD-L1) can identify tumors with aggressive ch

INFERNO : Galactic winds in dwarf galaxies with star-by-star simulations including runaway stars

The formation and evolution of galaxies have proved sensitive to the inclusion of stellar feedback, which is therefore crucial to any successful galaxy model. We present INFERNO, a new model for hydrodynamic simulations of galaxies, which incorporates resolved stellar objects with star-by-star calculations of when and where the injection of enriched material, momentum, and energy takes place. INFE

Predicting annual heating energy use using BIM : A simplified method for early design phase

Building information modeling (BIM) and building energy modeling (BEM) are two key tools to make the transition to net-zero energy buildings (NZEB). However, a recent literature review indicated that the conversion from BIM to BEM is currently dysfunctional, due to limitations regarding competencies, processes, and technology. In this article, a case study is presented to show how the information

Continued Stabilization of a Cementless 3D-Printed Total Knee Arthroplasty : Five-Year Results of a Randomized Controlled Trial Using Radiostereometric Analysis

BACKGROUND: Three-dimensional (3D) printing of highly porous orthopaedic implants aims to promote better osseointegration, thus preventing aseptic loosening. However, short-term radiostereometric analysis (RSA) after total knee arthroplasty (TKA) has shown higher initial migration of cementless 3D-printed tibial components compared with their cemented counterparts. Therefore, critical evaluation o

Tibial Component Undersizing Is Related to High Degrees of Implant Migration Following Cementless Total Knee Arthroplasty : A Study of Radiostereometric Analysis Data for 111 Patients with 2-Year Follow-up

Background: Radiostereometric analysis (RSA) studies have shown that the continuous migration of tibial components is predictive of aseptic loosening following total knee arthroplasty (TKA). In the present study, we investigated whether accurate sizing and placement of tibial components are related to the degree of implant migration as measured with use of RSA.Methods:A total of 111 patients who u

An improved adaptive neuro-fuzzy inference system for hydrological drought prediction in Algeria

Drought has negative impacts on water resources, food security, soil degradation, desertification and agricultural productivity. The meteorological and hydrological droughts prediction using standardized precipitation/runoff indices (SPI/SRI) is crucial for effective water resource management. In this study, we suggest ANFISWCA, an adaptive neuro-fuzzy inference system (ANFIS) optimized by the wat

Feature Detection and Description using a Harris-Hessian/FREAK Combination on an Embedded GPU

GPUs in embedded platforms are reaching performance levels comparable to desktop hardware, thus it becomes interesting to apply Computer Vision techniques. We propose, implement, and evaluate a novel feature detector and descriptor combination, i.e., we combine the Harris-Hessian detector with the FREAK binary descriptor. The implementation is done in OpenCL, and we evaluate the execution time and

Critical steps for computational inference of the 3′-end of novel alleles of immunoglobulin heavy chain variable genes - illustrated by an allele of IGHV3-7

Sequencing of immunoglobulin germline gene loci is a challenging process, e.g. due to their repetitiveness and complexity, hence limiting the insight in the germline gene repertoire of humans and other species. Through next generation sequencing technology, it is possible to generate immunoglobulin transcript data sets large enough to computationally infer the germline genes from which the transcr

Corporate ESG reporting quantity, quality and performance : Where to now for environmental policy and practice?

Environmental, social and governance (ESG) issues are driving corporate strategy and performance. However, does this mean more ESG reporting is being done? If so, is the quality of ESG reports improving? And what about ESG performance? In this paper, we examine these three trends in ESG reporting—quantity, quality and corporate ESG performance. With a Swedish multinational corporate focus, we anal

Pilot study of using resistivity-IP, magnetometry and slingram for separation of industrial waste

A controlled experiment was carried out by doing geophysical measurements on a purpose-built heap consisting of two different industrial waste fractions, called NF ( non-ferrous metal) and SLF (shredder light fraction), from the recycling plant of Stena Metall in Halmstad, Sweden. The purpose of the experiment was to see if it was possible to distinguish the different types of material using geoph

Modelling of metal cutting tool wear based on Archard’s wear equation

This article deals with an essential problem in the metal cutting industry, the problem of predicting tool wear and tool life. This is also a problem that has been studied by academia for the last century, often with very little added knowledge. The possibility to replace a large number of systematic wear tests with only a few specially designed tests provides new potentials for rapid information

In-situ soot characterization of propane flames and influence of additives in a 100 kW oxy-fuel furnace using two-dimensional laser-induced incandescence

In-situ soot characterization has been successfully performed in a 100 kWth down-fired oxy-fuel test furnace using laser-induced incandescence (LII) and extinction measurements. Primarily non-premixed propane flames were investigated in oxy-fuel mode with various concentrations of oxygen in the oxidant. The turbulent flame character was manifested through two-dimensional single-shot LII signals fr

Predictors of erythrocyte cadmium levels in 454 adults in Florence, Italy

Background: Cadmium bioaccumulates in the body and causes several adverse health effects. Understanding the primary sources of exposure is critical in order to implement effective prevention measures. Methods: We included 454 adults enrolled in the Florence cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC) during 1992–98. At enrolment, information was collected on d

Factors influencing the induction of high affinity antibodies to Plasmodium falciparum merozoite antigens and how affinity changes over time

Understanding the functional characteristics of naturally acquired antibodies against P. falciparum merozoite antigens is crucial for determining the protective functions of antibodies. Affinity (measured as kd) of naturally acquired antibodies against two key targets of acquired immunity, EBA175 and PfRh2, was determined using Surface Plasmon Resonance (SPR) in a longitudinal survey in Nigeria. A

Tailored chemical mechanisms for simulation of urban air pollution

A semi-stochastic, statistical reduction method for chemical kinetic schemes based on the ant colony optimization method, is developed for atmospheric chemistry simulations. The prime application is coupled dynamic and chemistry models for simulation of the dispersion and reactivity of chemical species on street scale, i.e. the modelling of urban air pollution in street canyons. The method is desi