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Poly(amido amine) (PAMAM) dendrimers have previously been shown, as cationic condensing agents of DNA, to have high potential for nonviral gene delivery. This study addresses two key issues for gene delivery: the interaction of the biomembrane with (i) the condensing agent (the cationic PAMAM dendrimer) and (ii) the corresponding dendrimer/DNA aggregate. Using in situ null ellipsometry and neutron

Popular Abstract in Swedish Blodet är sammansatt av många olika typer av mogna celler som är ansvariga för specialiserade roller inom blodsystemet. Röda blodceller transporterar syre till kroppens celler, vita blodceller förser oss med försvar mot mikroorganismer och blodplättar ser till att stoppa blödningar. Nybildning av blodceller behövs kontinuerligt eftersom vissa celler lever bara i några dThe blood is composed of many different cell types that through tightly regulated mechanisms are derived from hematopoietic stem cells (HSCs). In addition, HSCs are able to undergo self-renewing divisions whereby new HSCs are produced. This is an extremely important feature of HSCs in order to ensure the existence of the HSC pool that is paramount to provide life-long hematopoiesis. Aging is in ge

Apoptosis, followed by rapid phagocytic clearance, is the primary mechanism by which organisms dispose of unwanted cells. The intracellular and extracellular composition of an apoptotic cell changes to decrease immunogenicity and enhance its uptake. By changing their extracellular composition, apoptotic cells acquire the capacity to bind complement initiation molecules such as C1q and MBL. Binding

The chapter reviews evidence for the bodily mimesis hypothesis, which states that the evolution of language was preceded by an adaptation for improved volitional control of the body, giving our ancestors advantages in the domains of imitation, empathy, and gestural communication. Much of this evidence is also shared by other gesture-first theories of language origins, but they face the problem of

Pathogenic microbes acquire human complement inhibitors to circumvent the innate immune system. In this study, we identify two novel host-pathogen interactions, factor H (FH) and factor H-like protein 1 (FHL-1), the inhibitors of the alternative pathway that binds to Hib. A collection of clinical Haemophilus influenzae isolates was tested and the majority of encapsulated and unencapsulated bound F

The forefield of the Solheimajokull outlet glacier, South Iceland, has a variety of glacial landforms and sediments that are products of late Holocene and modern glacier oscillations. Several sets of moraine ridges reflect past ice front positions and river-cut sedimentary sections provide information about past environments. Here, we describe sediments and landforms deposited during the late Holo

Patrick Chamoiseau is arguably the most prominent cultural personality from the French island of Martinique. His reputation is due to the worldwide success of his novels, especially Texaco, winner of the Prix Goncourt-award in 1992, but also to the fact that he is the leading theorist of the Créolité, an ideological movement whose aim is to preserve the character of Creole identity and culture aga

Analysis of eye movements recorded with a mobile eye-tracker is difficult since the eye-tracking data are severely affected by simultaneous head and body movements. Automatic analysis methods developed for remote-, and tower-mounted eye-trackers do not take this into account and are therefore not suitable to use for data where also head- and body movements are present. As a result, data recorded w

This paper considers a class of control problems where there is a need to find switching-sequences between different linear systems, as well as linear control laws, to minimize some quadratic cost function. An algorithm to optimize the switching sequences for a class of switched linear problems is presented. The algorithm searches for solutions which are arbitrarily close to optimal finding the op

A number of CCS-technologies are currently being developed for the reduction of CO2 emissions from thermal power stations. One such technology is the oxyfuel process, in which a mixture of CO2 and steam is used as the working medium. The semi-closed oxyfuel combustion combined cycle (SCOC-CC) is an oxyfuel cycle where the working medium mainly consists of CO2 (85-95%). Current practice is to desig

We consider the following clustering problems: given a general undirected graph, partition its vertices into disjoint clusters such that each cluster forms a clique and the number of edges within the clusters is maximized (Max-ECP), or the number of edges between clusters is minimized (Min-ECP). These problems arise naturally in the DNA clone classification. We investigate the hardness of finding

This paper deals with bandwidth allocation in a Bluetooth scatternet. The proposed assignment of transmission rights provides a controlled traffic transfer between Bluetooth piconets and represents a key component in an ad-hoc wireless Bluetooth network in order to provide with efficient data packet passing within and across piconets. This assignment is obtained by executing a distributed algorith

Thermographic phosphors can be robust temperature remote sensors. The accuracy of the temperature measured by the phosphor is highly dependent on the quality of the phosphor calibration used. Conventionally, thermographic phosphors are calibrated by measuring a series of decay curves at known stable oven temperatures. The process is then repeated covering the thermal sensitivity range of the phosp

Gaia is ESA's ambitious space astrometry mission with a foreseen launch date in late 2011. Its main objective is to perform a stellar census of the 1,000 million brightest objects in our galaxy (completeness to V=20 mag) from which an astrometric catalog of micro-arcsec (μas) level accuracy will be constructed. A key element in this endeavor is the Astrometric Global Iterative Solution (AGIS) - th

Popular Abstract in Swedish Årligen diagnostiseras cirka 60 000 nya fall av cancer i Sverige (Socialstyrelsen, 2015), och var tredje person beräknas få en cancerdiagnos under sin livstid. Trots stora framsteg inom forskning och utveckling är cancer, näst efter hjärt- och kärlsjukdomar, den vanligaste dödsorsaken i vårt samhälle. Bland de tio vanligaste formerna av cancer hör lymfom, vilket är etMantle cell lymphoma (MCL) is an aggressive form of B-cell lymphoma (BCL) with poor clinical outcome. In this thesis, which is based upon five original papers, different approaches have been used to pinpoint and investigate molecular events that promote MCL tumor growth, progression or resistance to treatment. The aim has been to identify novel targets with the potential to eradicate malignant cel

En samling brev från av en svensk adelsdam, Beata Christina Strömfelt,(1737 - 1820) analyseras som talspråkliga.