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A formalism was recently introduced to instrument, monitor and control computer applications based on the rate of heartbeats they emit, thereby quantitatively signaling their progress toward goals. To date, the idea was however used essentially in an heuristic manner. This work first shows that a very simple dynamic heartbeat rate model can be devised, an that said model allows to address the corr
The global antimicrobial drug resistance crisis requires urgency in searching for more effective broad-spectrum antimicrobial drugs. Here, we present a complete circular genome sequence and a plasmid of an antimicrobial-producing isolate, Bacillus velezensis strain Sam8H1, from the Makgadikgadi saltpans in Botswana. Bioinformatic analyses revealed 12 putative secondary metabolite biosynthetic gene
The asymptotic behaviour of deterministic logit dynamics in heterogeneous routing games is analyzed. It is proved that in directed multigraphs with parallel routes, and in series composition of such multigraphs, the dynamics admits a globally asymptotically stable fixed point. Moreover, the unique fixed point of the dynamics approaches the set of Wardrop equilibria, as the noise vanishes. The resu
Urbanisation is proceeding at an alarming rate which forces wildlife to either retreat from urban areas or cope with novel stressors linked to human presence and activities. For example, urban stressors like anthropogenic noise, artificial light at night and chemical pollution can have severe impacts on the physiology of wildlife (and humans), in particular the immune system and antioxidant defenc
We present the results of a near-infrared (NIR) monitoring programme carried out between 1999 and 2005 to determine the variability properties of the 'Arecibo sample of OH/IR stars'. The sample consists of 385 IRAS-selected Asymptotic Giant Branch (AGB) candidates, for which their O-rich chemistry has been proven by the detection of 1612 MHz OH maser emission. The monitoring data were complemented
The Forum Romanum constituted the religious, political, economic and administrative centre of Rome for more than a millennium. During this time it went through several changes. It transformed from a liminal zone in the periphery of the Iron Age settlements into a communal space and sacred ground; later into an arena for political struggle and civic ambition; and finally into a showcase for Imperia
Introduction: There are multiple contributors to falls in older adults. Both health-related (poor balance, polypharmacy, and poor vision), and home-related (home hazards). However, most fall risk interventions only address one or two. The successful Lifestyle Intervention Functional Exercise (LiFE) program could likely be developed into a multicomponent intervention. Objectives: The objectives wer
A fundamental difference between ordinary and leisure time is for many the ability to indulge in extra-ordinary activities of both body and mind. Rooted in antiquity, the renaissance villas were often used as spaces for indulgence of artistic endeavors, be it philosophical discussions, poetry-writing or lavish parties. Of indulgence, Aristoteles wrote: ‘The self-indulgent man craves for all pleasa
The complement system resembles a double-edged sword since its activation can either benefit or harm the host. Thus, regulation of this system is of utmost importance and performed by several circulating and membrane-bound complement inhibitors. The pool of well-established regulators has recently been enriched with proteins that either share structural homology to known complement inhibitors such
According to results of a recent literature search performed by the European Academy of Dermatology and Venereology (EADV) Task Forces (TF) on Quality of Life and Patient Oriented Outcomes (QoL and PO) and Acne, Rosacea and Hidradenitis Suppurativa (ARHS), most of the publications where health-related (HR) QoL of acne patients was studied were clinical trials. Members of the EADV TF on QoL and PO
The molecular weight distribution and the viscosity of water‐soluble dietary fibre polysaccharides isolated from green beans, Brussels sprouts and green peas were investigated following boiling, microwave treatment and canning. Blanching was used as a reference process. In green beans and Brussels sprouts microwave treatment had minor effects, while there generally was a small decrease of neutral
The problem of optimizing PPM with the help of different choices of estimators and their parameters for different subsets of nodes in the context tree is considered. Methods of such optimization for Markov chain and context tree models for individual files and over given sets of files are presented, and it is demonstrated that the extension from Markov chain models to context tree models is necess
The aim of this paper is to discuss how research schools with a structured programme and targeted profile may make it difficult for doctoral students to expand the academic role. Our paper is based on material collected in a questionnaire given to doctoral students enrolled at a Swedish research school in architecture. In this questionnaire we found three areas – openness to other disciplines and
Context: Insulin resistance in skeletal muscle is a major risk factor for the development of type 2diabetes in women with polycystic ovary syndrome (PCOS). Despite this, the mechanisms underlyinginsulin resistance in PCOS are largely unknown.Objective: To investigate the genome-wide DNA methylation and gene expression patterns inskeletal muscle from women with PCOS and controls and relate them to
Identifying stars found in the Milky Way as having formed in situ or accreted can be a complex and uncertain undertaking. We use Gaia kinematics and APOGEE elemental abundances to select stars belonging to the Gaia-Sausage-Enceladus (GSE) and Sequoia accretion events. These samples are used to characterize the GSE and Sequoia population metallicity distribution functions, elemental abundance patte
A fuel mass estimation method for short pilot diesel injections is proposed and analyzed in this article. Previous studies showed that the pilot misfire ratio was more strongly correlated with the fuel mass than the on-time. This characteristic is exploited for the fuel mass estimation in a region where it is otherwise challenging to get good estimation accuracy due to the low signal-to-noise rati
