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SCM PRINCIPLES VS. LEGAL PRINCIPLES: CHALLENGES AND FRICTION

Purpose of this paper: Logisticians propose changes to improve supply chains, and legal practitioners are doing likewise, but from a tax perspective. Proposals from one domain increasingly have an impact on the other due to e.g. globalisation – but cross-disciplinary knowledge often seems small. Our purpose is to facilitate interaction between the domains by increasing joint understanding o

Clinical Outcomes of Surgical Release Among Diabetic Patients With Carpal Tunnel Syndrome: Prospective Follow-Up With Matched Controls.

PURPOSE: To compare the clinical outcome after carpal tunnel release in diabetic and nondiabetic patients. METHODS: We evaluated a prospective, consecutive series of 35 diabetic patients (median age, 54 years; 15 with type 1 and 20 with type 2 diabetes) with carpal tunnel syndrome, who were age- and gender-matched with 31 nondiabetic patients (median age, 51 years) having idiopathic carpal tunnel

Pathogenic Autoreactive B Cells Are Not Negatively Selected toward Matrix Protein Collagen II.

We have addressed the importance of B cell tolerance to collagen type II, a matrix protein, which is a target in rheumatoid arthritis (RA) and its mouse models. We generated a germline-encoded anti-collagen type II (CII) IgH replacement anti-C1 B cell mouse strain (ACB) to investigate how B cell tolerance to CII, a matrix protein, is subverted and to further understand pathogenesis of RA. Phenotyp

An approximate analysis of load balancing using stale state information for servers in parallel

That a load balancing strategy using stale information care lessly will incur system performance degradation is easy to verify. However it is not so obvious that routing a customer to the expected shortest queue has the same problem when information for decision is stale. We consider a queueing system with a load balancer and a pool of identical FCFS queues in parallel. The arrival process is assu

The Double Disjunction Task as a Coordination Problem

In this paper I present the double disjunction task as introduced by Johnson-Laird. This experiment is meant to show how mental model theory explains the discrepancy between logical competence and logical performance of individuals in deductive reasoning. I review the results of the task and identify three problems in the way the task is designed, that all fall under a lack of coordination between

Differential gene expression in adipose tissue from obese human subjects during weight loss and weight maintenance.

BACKGROUND: Differential gene expression in adipose tissue during diet-induced weight loss followed by a weight stability period is poorly characterized. Markers of these processes may provide a deeper understanding of underlying mechanisms. OBJECTIVE: We aimed to identify differentially expressed genes in human adipose tissue during weight loss and weight maintenance after weight loss. DESIGN:

Autoimmune and chronic inflammatory disorders and risk of non-Hodgkin lymphoma by subtype

Background. Some autoimmune and chronic inflammatory disorders are associated with increased risks of non-Hodgkin lymphoma (NHL). Because different NHL subtypes develop at different stages of lymphocyte differentiation, associations of autoimmune and inflammatory disorders with specific NHL subtypes could lead to a better understanding of lymphomagenic mechanisms. Methods: In a population-based ca

Kit regulates maintenance of quiescent hematopoietic stem cells.

Hematopoietic stem cell (HSC) numbers are tightly regulated and maintained in postnatal hematopoiesis. Extensive studies have supported a role of the cytokine tyrosine kinase receptor Kit in sustaining cycling HSCs when competing with wild-type HSCs posttransplantation, but not in maintenance of quiescent HSCs in steady state adult bone marrow. In this study, we investigated HSC regulation in Whit

The prosody of contrastive topics in Southern Swedish

This paper presents a pilot study on the prosodic marking of a contrastive topic in Southern Swedish. A test sentence was elicited in three experimental conditions: initial focus; final focus; contrastive topic (initial word) plus focus (final word). F0 patterns were analysed in recordings of 10 speakers. A majority of the speakers distinguished clearly between the conditions, but speakers employe

Efficient Pruning of Search Trees in LQR Control of Switched Linear Systems

This paper considers off-line optimization of a switching sequence fora given finite set of linear control systems and joint optimization ofcontrol laws. A linear quadratic full information criterion isoptimized and dynamic programming is used to find the optimalswitching sequence and control laws. The main result is a method for efficient pruning of the search tree to avoid combinatoric explosion

Computer-Aided Planning of New Production Lines in Mechanical Industries and of Working Environments for Disabled Persons

To optimize productivity and working-life quality, it is important to understand and utilise the connections between productivity and working environment. Culture and the state of the market may affect the strength of these connections. However, in order to ensure flexibility and quality in products and services, it may be useful to have motivated, skilled and responsible coworkers at all levels.

Laminin G Domains, their Receptors, and Activation of Intracellular Pathways

Popular Abstract in Swedish Extracellulär matrix är namnet på det molekylära nätverk vilket finns mellan celler i flercelliga organismer. Det består av socker och proteiner organiserade i olika vävnadsspecifika nätverk. Två huvudformer finns, basalmembran och interstitiell extracellulär matrix. Basalmembran ligger som en tunn filt under epitel- och endotelceller, runt fettväv, muskler och periferaBasement membranes are sheet like structures underlying epithelial, endothelial, adipocytes, muscle and peripheral nerve cells. Laminins are an important family of basement membrane proteins implicated in various biological functions through their interactions with cell surface receptors. Laminins are trimers composed of a, b and g chains. Integrins, dystroglycan and other transmembrane glycoprote

The immunomodulatory properties of C-Med 100 an extract of the plant Uncaria tomentosa

Popular Abstract in Swedish C-Med 100, en naturmedicin med immunomodulerande egenskaper Vårt immunsystem skyddar oss mot infektioner från bakterier, virus och parasiter. För att detta ska fungera behövs många olika egenskaper och idag delas immunsystemet in i två delar, en ospecifik och en specifik. Den ospecifika delen består av hud, slemhinnor, magsyra och olika celler som snabbt tar sig till etExtracts from the bark of the vine Uncaria tomentosa have anti-inflammatory, antiviral, antimutagenic and antioxidant effects. In this study, we evaluate the effects of an Uncaria tomentosa extract, denoted C-Med 100, on the cellular level of the immune system both in vivo and in vitro. Our results indicated that lymphocytes had significantly prolonged half life after in vivo supplementation with

NKT cells promote both type 1 and type 2 inflammatory responses in a mouse model of liver fibrosis

Sterile liver inflammation and fibrosis are associated with many liver disorders of different etiologies. Both type 1 and type 2 inflammatory responses have been reported to contribute to liver pathology. However, the mechanisms controlling the balance between these responses are largely unknown. Natural killer T (NKT) cells can be activated to rapidly secrete cytokines and chemokines associated w