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The αE integrin chain CD103 identifies a subset of migratory dendritic cells (DCs) in the gut, lung, and skin. To gain further understanding of the function of CD103(+) DCs in regulating adaptive immunity in vivo, we coupled ovalbumin (OVA) to the CD103 antibody M290 (M290.OVA). Intraperitoneal injection of M290.OVA induced OVA-specific CD8(+) and CD4(+) T-cell proliferation in lymph nodes (LNs) o

Current treatments that are efficient in controlling effector T cells responses to allografts have limited efficacy on the accelerated rejection mediated by memory T cells. Effective targeting of alloreactive memory T cells may therefore be explored to improve therapeutic approaches towards solving this problem. In this study, we investigated the synergistic effect of CD44/CD70 blockade and anti-C

Atypical hemolytic uremic syndrome has been associated with dysregulation of the alternative complement pathway. In this study, a novel heterozygous C3 mutation was identified in a factor B-binding region in exon 41, V1636A (4973 T > C). The mutation was found in three family members affected with late-onset atypical hemolytic uremic syndrome and symptoms of glomerulonephritis. All three patients

Lakes and vegetation are important factors of the Earth's hydrological cycle and can be called an “indicator” of climate change. In this study, long-term changes of lakes' area and vegetation coverage in the Qinghai-Tibetan Plateau (QTP) and their relations to the climate change were analyzed by using Mann-Kendall method during the past 30 years. Results showed that: 1) the lakes' area of the QTP

An investigation of the fundamental frequency in Swedish feedback words is presented. It is hypothesised that the F0-pattern differs between words signalling positive and negative feedback-i.e. agreement and disagreement with the utterance of the preceding speaker. When imitating the contrast, the negative feedback word nej 'no' is often produced with a falling F0, stretching over a larger range,

The European Academy of Allergy and Clinical Immunology (EAACI) organized the first European Strategic Forum on Allergic Diseases and Asthma. The main aim was to bring together all relevant stakeholders and decision-makers in the field of allergy, asthma and clinical Immunology around an open debate on contemporary challenges and potential solutions for the next decade. The Strategic Forum was an

Spotted fever group (SFG) Rickettsia species are inoculated into the mammalian bloodstream by hematophagous arthropods. Once in the bloodstream and during dissemination, the survival of these pathogens is dependent upon the ability of these bacteria to evade serum-borne host defenses until a proper cellular host is reached. Rickettsia conorii expresses an outer membrane protein, Adr1, which binds

Bacterial proteases are important enzymes used in several technical applications where controlled cleavage of proteins is needed. They are challenging enzymes to express recombinantly as parts of the proteome can be hydrolyzed by their activity. The eukaryotic model organism Saccharomyces cerevisiae is potentially a good expression host as it tolerates several stress conditions and is known to bet

Gastric cancer is a dominating cause of cancer-associated mortality with limited therapeutic options. Here, we show that syndecan-4 (SDC4), a transmembrane proteoglycan, is highly expressed in intestinal subtype gastric tumors and that this signature associates with patient poor survival. Further, we mechanistically demonstrate that SDC4 is a master regulator of gastric cancer cell motility and in

Visual information can be integrated in prominence perception, but most available evidence stems from controlled experimental settings, often involving synthetic stimuli. The present study provides evidence from spontaneously produced head gestures that occurred in Swedish television news readings. Sixteen short clips (containing 218 words in total) were rated for word prominence by 85 adult volun

Soil is an interface of the lithosphere, biosphere, hydrosphere and atmosphere that provides a habitat for microbial growth. The microbial biomass forms an integral part of the soil. The physiological potential and diversity of the microbial communities in soils are strongly associated with the physicochemical properties of soils. The biotic and abiotic characteristics determine the structure and

This chapter focuses on communication-centered change research and its implications for public sector organizations. It focuses on the organizational level and the communication processes through which changes are enacted. Special attention is given to coworkers and how they make sense in times of changes. Sensemaking processes play a crucial role in organizational changes; if managers and employe

Circular Economy regulation is rapidly adopted at different levels of governance, including municipalities, private and industry standards, national law and supranational standard-setting. There are increasing demands from policymakers, businesses and civil society for theoretical insights and more knowledge on the effects of policies and laws ('policy learning'). However, despite this mounting in

Modellering av smältavrinning med kort tidsupplösning

Increased shale gas extraction through hydraulic fracturing and its distribution through shale gas pipelines have brought about innumerable socioeconomic consequences, both tangibly and intangibly. Evidence remains unclear on what are the impacts of shale gas developments on property values. By employing a mixed method approach, combining original data collected in the Marcellus Shale through inte

Denna avhandling undersöker skapandet och omvandlingen av offentliga platser i Hongkong, en stad som är genomsyrad av nyliberala ideal och som under senare år har kännetecknats av betydande försämringar när det gäller demokratiska rättigheter och friheter. Som ett resultat av den nyliberala kapitalismens expansion har kommodifieringen av det urbana rummet inte bara förvärrats utan också blivit merThis thesis explores the production and transformation of public spaces in Hong Kong, a city that is steeped in neoliberal ideals and has seen substantial deterioration in terms of democratic rights and freedoms in recent years. As a result of the expansion of neoliberal capitalism, commodification of urban space has not only exacerbated, but also become more far-reaching and indiscriminate. While

Background: Eosinophils are innate immune cells present in the intestine during steady state conditions. An intestinal eosinophilia is a hallmark of many infections and an accumulation of eosinophils is also observed in the intestine during inflammatory disorders. Classically the function of eosinophils has been associated with tissue destruction, due to the release of cytotoxic granule contents.

Mechanical damage at the time of joint injury and the ensuing inflammatory response associated with elevated levels of pro-inflammatory cytokines in the synovial fluid, are reported to contribute to the progression to osteoarthritis after injury. In this exploratory study, we used a targeted proteomics approach to follow the progression of matrix degradation in response to mechanical damage and cy

The 1976 premiere of Face to Face came at the height of director-screenwriter Ingmar Bergman's career. Prestigious awards and critical acclaim had made him into a leading name in European art cinema, yet today Face to Face is a largely overlooked and dismissed work.This book tells the story of its rise and fall. It presents a new portrait of Bergman as a political artist exploring a new medium wit