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PurposeLonger and heavier road freight vehicles, so called High Capacity Vehicles (HCVs) are likely to be implemented by the Swedish government in the near future. This paper analyses the effects on tonne-kilometres, vehicle-kilometres, CO2 and socio-economics of three possible implementation strategies (HCVs on all roads, a designated road network, a designated road network with km-based truck ch
We investigate here populations of cataclysmic variables (CVs) in a set of 288 globular cluster (GC) models evolved with the MOCCA code. This is by far the largest sample of GC models ever analysed with respect to CVs. Contrary to what has been argued for a long time, we found that dynamical destruction of primordial CV progenitors is much stronger in GCs than dynamical formation of CVs, and that
Pollutions on and within the underground poses risks for groundwater contamination and is a widespread global problem. Common remediation methods based on digging and removal can be expensive and have limitations, while in-situ remediation is an attractive alternative. However, there is a need to develop tools to monitor the effectiveness both in terms of the successful injection of remediation fl
We investigate the impact of a galaxy’s merger history on its system of satellites using the new VINTERGATAN-GM suite of zoom-in hydrodynamical simulations of Milky Way-mass systems. The suite simulates five realizations of the same halo with targeted ‘genetic modifications’ of a z ≈ 2 merger, but resulting in the same halo mass at z = 0. We find that differences in the satellite stellar mass func
CONTEXT: Cardiometabolic multimorbidity (CM) is an increasing public health concern. Previous observational studies have suggested inverse associations between coffee, tea, and caffeine intake and risks of individual cardiometabolic diseases; however, their associations with CM and related biological markers are unknown.METHODS: This prospective study involved 172 315 (for caffeine analysis) and 1
Italian is sexy, German is rough—but how about Páez or Tamil? Are there universal phonesthetic judgments based purely on the sound of a language, or are preferences attributable to language-external factors such as familiarity and cultural stereotypes? We collected 2,125 recordings of 228 languages from 43 language families, including 5 to 11 speakers of each language to control for personal vocal
At the 2015 UN Climate Change Conference in Paris, nations around the world reached a landmark agreement to unify in an effort to combat climate change. The main goal of the Paris agreement is to strengthen the global response to the threat of climate change by keeping global temperature rise well below 2°C above pre-industrial levels and preferably to limit the temperature rise even further to 1.
Abstract in Spanish En el presente trabajo buscamos poner en cuestión la relación entre desarrollo, desigualdad y territorio en el contexto actual de la globalización y en el marco de las políticas públicas dirigidas, supuestamente, a favorecer a los actores sociales de menores recursos. Para ello nos centramos en un estudio de caso en el nordeste de la provincia de Misiones, Argentina. Aquí la ac
In this paper it is shown that the central features of systematic engineering design process models: a step-by-step concretisation of the product with a systematic variation of subsolutions and recombination are not absolutely necessary. Current models are neither generic nor ideal. Instead of using product characteristics as a basis for design process models, the focus should be on the concrete g
The structure, formation, and evolution of the Milky Way bulge is a matter of debate. Important diagnostics for discriminating between models of bulge formation and evolution include alpha-abundance trends with metallicity, and spatial abundance and metallicity gradients. Due to the severe optical extinction in the inner Bulge region, only a few detailed investigations of this region have been per
P>Diagnosing candidaemia remains difficult despite the development of new diagnostics. We report a direct comparison of three different blood-culture systems and four indirect tests. One hundred and fourteen episodes either with haematological disease and fever despite antibacterials, or with documented invasive candidiasis, were enrolled prospectively. Clinical, para-clinical information and surv
Despite the unprecedented interest in organic-inorganic metal halide perovskite solar cells, quantitative information on the charge transfer dynamics into selective electrodes is still lacking. In this paper, we report the time scales and mechanisms of electron and hole injection and recombination dynamics at organic PCBM and Spiro-OMeTAD electrode interfaces. On the one hand, hole transfer is com
Streptococcal toxic shock syndrome is frequently caused by Streptococcus pyogenes of the M1 serotype. The aim of this study was to determine the role of Ras-homologous (Rho)-kinase signaling in M1 protein-provoked lung damage. Male C57BL/6 mice received the Rho-kinase-specific inhibitor Y-27632 before administration of M1 protein. Edema, neutrophil accumulation and CXC chemokines were quantified i
Nasal decolonisation has a proven effect on the prevention of severe Staphylococcus aureus infections and in the control of methicillin resistant S. aureus (MRSA). However, rising rates of resistance to antibiotics highlights the need for new substances for nasal decolonisation. LTX-109 is a broad spectrum, fast-acting bactericidal antimicrobial drug for topical treatment, which causes membrane di
We present new in-situ measurements of particle rotations and energy dissipation during compression of 3D packings of stiff, frictional particles. Two confined, uniaxial compression tests with different degrees of lateral confinement are discussed. X-ray computed tomography and 3D X-ray diffraction were combined to provide inter-particle forces, slip and roll distances, twist angles, and energy di
Quinoline-3-carboxamides (Q substances) are small molecule compounds with anti-inflammatory properties. In this study, we used one of these substances, Paquinimod, to treat a novel model for chronic liver inflammation and liver fibrosis, the NOD-Inflammation Fibrosis (N-IF) mouse. We show that treatment of N-IF mice significantly reduced inflammation and resulted in the regression of fibrosis, eve
The early form of Integrated Water Resources Management (IWRM) emerged in the USA in the 1900s in order to manage interactions between water, land, eco- and social systems. By the end of the last century, IWRM has become a globally prominent policy concept. We concern ourselves with three questions, namely, a) “why did IWRM become a globally popular concept”?; b) “how did IWRM become a globally po
Complement system aberrations have been identified as pathophysiological mechanisms in a number of diseases and pathological conditions either directly or indirectly. Examples of such conditions include infections, inflammation, autoimmune disease, as well as allogeneic and xenogenic transplantation. Both prospective and retrospective studies have demonstrated significant complementrelated differe
