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Bikunin is a Kunitz-type proteinase inhibitor, which is cross-linked to heavy chains via a chondroitin sulfate chain, forming inter-alpha-inhibitor and related molecules. Rat bikunin was produced by baculovirus-infected insect cells. The protein could be purified with a total yield of 20 mg/liter medium. Unlike naturally occuring bikunin the recombinant protein had no galactosaminoglycan chain. En
Selective infection of phage is when the bacterial infection depends on the specific molecular interaction between an antigen and a phage-displayed protein sequence such as an antibody. Engineering of the normal infection into pathways, directed by a specific protein--protein interaction, has raised several mechanistic questions. Here, we address the type of display and the affinity between the in
Asthma is a highly prevalent condition across Europe and numerous guidelines have been developed to optimise management. However, asthma can be neither cured nor prevented, treatment choices are limited and many patients have poorly controlled or uncontrolled asthma. The Brussels Declaration on Asthma, sponsored by The Asthma, Allergy and Inflammation Research Charity, was developed to call attent
A single intradermal injection of the mineral oil pristane in susceptible DA.1F rats induces erosive arthritis closely mimicking rheumatoid arthritis (RA). Pristane-induced arthritis (PIA) is driven by autoreactive T cells but no autoantigen has been identified to date. We therefore analyzed B and T cell responses to autoantigens potentially involved in the pathogenesis of RA, including IgG, citru
Popular Abstract in Swedish I sökandet efter den rådande fostrings- och disciplineringsdiskursen i svensk skola åren 1947-1956 har Michel Foucaults diskursanalys utgjort en central utgångspunkt i denna avhandling. Jag har inledningsvis redogjort för modernitetens genombrott i Sverige och kort belyst befolkning och utbildning vid mitten av 1900-talet. Skolan som disciplineringsinstitution har beskThe purpose of this monograph is to discern what constituted the dominant fostering and discipline discourse in Swedish compulsory schools during the period 1947-1956. For this purpose Michel Foucault's discourse analysis has played a central role in this thesis. As a starting point, an account of the emergence of modernity in Sweden is given, as well as a brief presentation of the Swedish populat
This study considers the spread, character and development of the Swedish Enlightenment from the early Age of Liberty to the late Karl lohan period. This is done in six case studies three of them biographical and three of them of a more general character partly concerned with the history of concepts; all six case studies touch on the writers' world in the period. Chapter 1, "Dawn", discusses, aft
Context.-The diagnostic distinction of pulmonary neuroendocrine (NE) tumors from non-small cell lung carcinomas (NSCLCs) is clinically relevant for prognostication and treatment. Diagnosis is based on morphology and immunohistochemical staining. Objective.-To determine the diagnostic value of insulinoma-associated protein 1 (INSM1), in comparison with established NE markers, in pulmonary tumors. D
The Haro 11 galaxy merger is the closest known Lyman continuum (LyC) leaker and a strong Lyman-α (Lyα) emitter, making it an important analogue of the high-z galaxies that reionised the early Universe. To investigate how Haro 11’s properties arise, we perform a radiation hydrodynamics simulation of the merger, and create mock observations of LyC, Lyα, and Hα, from which we compute their luminositi
This chapter explores the intricate dynamics of transnational Shia networks and their relationship with Iran, focusing on the latter's aspiration to dominate global Shiism and the resistance it faces. It analyzes the transnational character of Shia clerical networks, which have been pivotal in political and communal mobilization since the 1950s, particularly in Iraq. Post-1979, Iran leveraged thes
Parity forbidden radiative transitions from metastable levels are observed in spectra of low-density astrophysical plasmas. These lines are used as probes of the physical conditions, made possible due to the long lifetime of their upper level. In a joint effort, the FERRUM project aims to obtain new and accurate atomic data for the iron-group elements, and part of this project concerns forbidden l
This thesis explores the name, naming and naming politics in three poetic texts which exhibit a concern with the normative force of language: Cristina Peri Rossi’s Evohé (1971), Julia Álvarez’ The Other Side/El otro lado (1995) and Ana Arzoumanian’s (2006) Juana I. In Evohé the woman-body and the woman-word collide and penetrate each other; in The Other Side/ El otro lado the English code conflict
The N-body problem has been studied for many centuries and is still of interest in contemporary science. A lot of effort has gone into solving this problem but it's unlikely that a general solution will be found with the mathematical tools we have today. We review some of the progress that has been made over the centuries in solving it. We take a look at the first integrals, existence of solut
OBJECTIVES: To assess the extent to which knee extensor strength and weight in adolescence are associated with knee osteoarthritis (OA) by middle age.METHODS: We studied a cohort of 40 121 men who at age 18 years in 1969/1970 underwent mandatory conscription in Sweden. We retrieved data on isometric knee extensor strength, weight, height, smoking, alcohol consumption, parental education and adult
Water availability and water demand are not evenly distributed in time and space. Many mega water diversion projects have been launched to alleviate water shortages in China. This paper analyzes the temporal and spatial features of 59 mega water diversion projects in China using statistical analysis. The relationship between nine major basins is measured using a network analysis method, and the as
