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Although CD8+ T cell tolerance to tissue-specific antigen (TSA) is essential for host homeostasis, the mechanisms underlying peripheral cross-tolerance and whether they may differ between tissue sites remain to be fully elucidated. Here, we demonstrate that peripheral cross-tolerance to intestinal epithelial cell (IEC)–derived antigen involves the generation and suppressive function of FoxP3+CD8+

I discuss the dilution of responsibility of action and the idea of a symmetrical relationship between artefacts and humans. In doing so, I argue that meaning making is an activity unilaterally performed by agents, leading to an asymmetrical relationship between agents and artefacts. Therefore, the study of the one who is responsible for the action, the meaning-maker (with the capability to act) is

Background: Mohs micrographic surgery (MMS) is a precise, tissue-sparing surgical technique that offers superior cure rates compared to traditional surgical excision. However, the degree of difficulty of MMS depends on many variables, and consequently, the number of surgical stages required for each case is quite unpredictable.Objectives: To identify risk factors for complicated MMS, defined as MM

A frequency domain, weighted least squares, sensitivity function shaping procedure is presented. Pole placement is used as the basic servo design procedure. Controller overparametrization gives the degree of freedom for shaping the sensitivity function. A benchmark design example shows the capabilities of the method. The computation is simple making the design suitable for adaptive control.

Current techniques to determine functional or effective connectivity from magnetoencephalography (MEG) and electroencephalography (EEG) signals typically involve two sequential steps: 1) estimation of the source current distribution from the sensor data, for example, by minimum-norm estimation or beamforming, and 2) fitting a multivariate autoregressive (MVAR) model to estimate the AR coefficients

In the eighteenth century, the portrait genre, previously restricted to royalty and nobility, became available to users from a broader social spectrum. All over Europe, physicians, scholars, writers, merchants, and proprietors had their portraits painted to mark their standing in society. However, not these grand paintings but their printed versions made the sitters known to the broader public. Bu

Occupational therapists support and enable people to partake in occupations or activities that are important to them; that they need/want/are expected to do. Occupational therapists are increasingly involved in services addressing the impact that social inequalities can have on peoples’ wellbeing. One way in which occupational therapy students in NUI Galway learn relevant skills is through service

The enactment of the revised Payment Services Directive (PSD2) by the European Union, has pushed banks to develop digital open banking platforms to enhance market competition and promote innovation in the banking industry. PSD2 mandates banks to offer APIs to provide access to banking data to external third-party providers (TPPs). This mandate might disrupt the role of banks since external complem

Rationale: Recent randomized controlled trials did not show cardiovascular benefits of continuous positive airway pressure (CPAP) in adults with coronary artery disease (CAD) and obstructive sleep apnea (OSA) in intention-to-treat analyses. It has been argued that exclusion of patients with OSA with excessive daytime sleepiness (EDS), who may be most likely to benefit from CPAP treatment, may be a

We recently reported that female patients with hypopituitarism receiving controlled thyroid and steroid hormone substitution, but without GH replacement, had a more than 2-fold increase in cardiovascular mortality compared to the general population. In the present study we investigated the incidence of cardiovascular disease as well as the prevalence of cardiovascular risk factors in 33 females wi

We consider the problem of sharing sensitive files across users while relying on a common, untrusted third-party, e.g., a Cloud Storage Provider (CSP). Although users can rely on a secure peer-to-peer (P2P) channel for file sharing, this introduces potential delay on the data transfer and requires the sender to remain connected while the transfer process occurs. Instead, users can upload informati

This paper analyzes the problem and requirements of securely distributing software updates over the Internet,to devices in an Industrial Control System (ICS) and more generally in Internet of Things (IoT) infrastructurescontrolling a physical system, such as power grids and water supply systems. We present a novel approachthat allows to securely distribute software updates of different types, e.g.

Solar mean magnetic field (SMMF) measurements from the Wilcox SolarObservatory and with SOHO/MDI are analyzed using continuous wavelettransforms, SMMF variability is found at a number of temporal scales.Detected SMMF variations with a 1-2 year period is considered to belinked to long-term variations in the internal rotation of the Sun.Intermediate SMMF oscillations with a period of 80-200 days are

OBJECTIVE: We have evaluated a new technique of cardiac de-airing that is aimed at a) minimizing air from entering into the pulmonary veins by opening both pleurae and allowing lungs to collapse and b) flushing out residual air from the lungs by staged cardiac filling and lung ventilation. These air emboli are usually trapped in the pulmonary veins and may lead to ventricular dysfunction, life-thr

The authors present in this paper how the extended Mie theory can be used to translate not only end-point data but also temporal variations of extinction peak-position changes, peak(t), into absolute mass uptake, (t), upon biomacromolecule binding to localized surface plasmon resonance (SPR) active nanoparticles (NPs). The theoretical analysis is applied on a novel sensor template composed of a th

Interfacial electron transfer is one of the key processes in the novel type of photovoltaic cells-dye sensitized solar cells (DSSC). By means of transient absorption spectroscopy we have studied the dynamics of the initial photo-induced processes in dye-sensitized nano-porous thin films of wide-band gap semiconductor microcrystallines, which represent the main photoactive part of DSSC. In the most

BACKGROUND: The epidemiology of hepatitis C virus (HCV) infection has been studied in many countries. However, little is known about HCV infection in Lithuania, a Baltic country, that was part of the former Soviet Union. OBJECTIVES: The aim of this study was to determine and evaluate the etiology of acute viral hepatitis, the risk factors for acquiring HCV in comparison to hepatitis B virus (HBV),

Specific immunotherapy (SIT) is the only treatment with proved long-term curative potential in patients with allergic disease. Allergen-specific IgE is the causative agent of allergic disease, and antibodies contribute to SIT, but the effects of SIT on aeroallergen-specific B-cell repertoires are not well understood.