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A detailed dynamical investigation of the proposed QS Virginis planetary system

In recent years, a number of planetary systems have been proposed to orbit-evolved binary star systems. The presence of planets is invoked to explain observed variations in the timing of mutual eclipses between the primary and secondary components of the binary star system. The planets recently proposed orbiting the cataclysmic variable system QS Virginis are the latest in this ongoing series of `

Insights into weak affinity antibody-antigen interactionsStudies using affinity chromatography and optical biosensor

Popular Abstract in Swedish I cellen styrs allt av biomolekylernas förmåga till igenkänning och växelverkan med varandra. Molekylernas speciella egenskaper bygger upp kroppens alla komplicerade funktioner, till exempel immunförsvar, celldelning och muskelarbete. Interaktionerna mellan biomolekylerna kan vara av olika karaktär; de beskrivs som starka eller svaga (affinitet), långsamma eller snabba Molecular recognition and interaction is fundamental for the function of biological systems. The properties of the interacting biomolecules dictate the type of forces involved and the strength and dynamics of the interaction. Many interactions are very strong whereas others exhibit weak affinity. Typically, weak interactions work in concert to trigger a biological response. The advantage with thi

The estrogen receptor in fish and effects of synthetic estrogens in the environment - Ecological and evolutionary perspectives and societal awareness

Popular Abstract in Swedish Vår läkemedelsanvändning har eskalerat de senaste två årtionden och vi har kunnat behandla, bota och förebygga sjukdomar samt minskat antalet oönskade graviditeter i större utsträckning jämfört med förr. Detta har dock också fört med sig negativa effekter och miljöproblem efter att läkemedlen kommer ut i naturen. Ett antal läkemedel är så kallade endokrina störningssubsSynthetic hormones are a group of pharmaceuticals used for various human and animal treatments. However, consumption and disposal of these substances have also given rise to negative effects and environmental problems for organisms in the wild which is why these substances have been classified as estrogenic endocrine-disrupting chemicals (EDCs). Studies on the estrogen receptors (ers) and their ge

Dendritic cell interactions with Gram negative bacteria

Popular Abstract in Swedish För att skydda sig mot omgivande virus, bakterier och parasiter har kroppen utvecklat ett speciellt försvar. Detta försvar utgörs av ett komplext nätverk av celler och lösliga komponenter som interagerar med varandra. En del av kroppens försvar utgörs av fysiska barriärer så som huden och av celler som är specialiserade på att ta upp och döda angripande mikroorganismer.The interaction between murine bone marrow-derived dendritic cells (DC) and the Gram negative bacteria Salmonella typhimurium and Escherichia coli have been characterised. These studies showed that DC phagocytosed and processed S. typhimurium and E. coli expressing defined epitopes for peptide presentation on major histocompatibility complex class I (MHC-I) and class II (MHC-II) molecules. Process

Best Practice Guideline: Transportation of People Seated in Wheelchairs, Version 2.21.

Summary, key points: Transport considerations ought to be factored into the initial phase of the wheelchair & seating assessment process. Manufacturers of wheelchairs and seating systems should make information relating to the safe transportation of their products readily available - and easy to understand. With the desire to provide the safest possible transport environment for wheelchair-se

Valuation of Supply Chain Flow Risks by Indexing

The paper is based on a general conceptual supply chain flow risk model developed in an earlier paper, a literature review and case studies. The paper has the title "Developing a supply chain risk model" and is reported as a final paper at the NOFOMA 2005 conference. The literature review has been focusing articles and reports/books on supply chain management. Some of its findings have earlier bee

A social perspective on the interview technique in design research. Part I: Interviews in design research

Many studies focusing on design activities use the interview technique as part of their investigation. Nevertheless, methodological discussions about the interview setting as the locus of a social interaction between the interviewer and the respondent and its implications for the interpretation of the data obtained are rarely found in publications within our design community. Part I of this public

Sociology and the New Institutionalism

In sociology, new institutionalists led the revival in interest in institutions in organizational theory and economic sociology by shifting the focus of causal reasoning from agent-centric studies of economic and organizational actors to the relationship connecting the firm with its institutional environment. We suggest a multilevel causal model incorporating the connection between the subinstitut

B cell activation in vitro: thymus-dependent immune responses and bacterial cell surface proteins

In this thesis aspects of peripheral B lymphocyte differentiation were studied. Through in vitro experiments, B lymphocyte activation was assessed. B lymphocytes express immunoglobulin (Ig) specific for a certain antigen on the cell surface, and when surface Ig is crosslinked by an antigen, the cell is activated. Antigens giving rise to a T cell dependent immune response are internalized by the B

Comparative study of the student's design process: Implications for the teaching of the later phases of the mechanical engineering design process

Most methods that guide the designer through the later phases of the design process are general in nature, and it is up to the designer to organize the design work using the tools and techniques available. This process also relies greatly on experience, which is quite a challenge for students, who are mostly novices in the area. In a comparative study, the evolution of the experience and skills ac

A social perspective on the interview technique in design research. Part II: The interview as a social situation

Many studies focusing on the design activity use the interview technique as a part of their investigation. Methodological discussions about the interview setting as the locus of a social interaction between the interviewer and the respondent and its implications for the interpretation of the obtained data are nevertheless rarely found in publications within our design community. Part I of this pub

Water Interactions with Acetic Acid Layers on Ice and Graphite

Adsorbed organic compounds modify the properties of environmental interfaces with potential implications for many Earth system processes. Here, we describe experimental studies of water interactions with acetic acid (AcOH) layers on ice and graphite surfaces at temperatures from 186 to 200 K. Hyperthermal D2O water molecules are efficiently trapped on all of the investigated surfaces, with only a

The Growing Emphasis on Social Citizenship in Nordic Education – Inducing New Social Risks While Trying to Alleviate Them

Education as a social right has been gaining strong prominence in the Nordic countries transition towards the post-industrial society. I focused the Swedish educational system. The study finds that the right to education turned into a moral duty to be an enlightened citizen. The interviewees’ stigmatize vocational programmes and encourage pupils to choose ‘right’ meaning school-based education. A

Lactadherin binds to elastin - a starting point for medin amyloid formation?

Medin amyloid is found in the medial layer of the aorta in almost 100% of the Caucasian population over 50 years of age. The medin fragment is 5.5 kDa and derives from the C2-like domain of the precursor protein lactadherin. We have previously reported immunohistochemical findings showing that medin amyloid co-localizes with elastic fibers of arteries and herein we show that lactadherin also is as

Increased Sensitivity to Broadly Neutralizing Antibodies of End-Stage Disease R5 HIV-1 Correlates with Evolution in Env Glycosylation and Charge.

Induction of broadly neutralizing antibodies, such as the monoclonal antibodies IgGb12, 2F5 and 2G12, is the objective of most antibody-based HIV-1 vaccine undertakings. However, despite the relative conserved nature of epitopes targeted by these antibodies, mechanisms underlying the sensitivity of circulating HIV-1 variants to broadly neutralizing antibodies are not fully understood. Here we have

Domain wall-grain boundary interactions in polycrystalline Pb(Zr0.7Ti0.3)O3 piezoceramics

Interactions between grain boundaries and domain walls were extensively studied in ferroelectric films and bicrystals. This knowledge, however, has not been transferred to polycrystalline ceramics, in which the grain size represents a powerful tool to tailor the electromechanical and dielectric response. Here, we relate changes in dielectric and electromechanical properties of a bulk polycrystalli