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OBJECTIVES: Vesicular drug delivery has become a useful approach for therapeutic administration of pharmaceutical compounds. Lipid vesicles have found application in membrane biology, immunology, genetic engineering and theragnostics. This review summarizes topical delivery, specifically dermal/transdermal, ocular and transungual, via these vesicles, including future formulation perspectives. KEY
Background: Monitoring metabolites of tamoxifen, such as endoxifen, has been suggested as a strategy to ascertain therapeutic effect of tamoxifen therapy, but clinical guidelines are missing. Herein, we aim to investigate the outcome of endoxifen concentrations of low-dose tamoxifen, using change in mammographic breast density as a proxy for therapy response. Methods: In the randomized KARISMA-Tam
Wireless ad hoc networks have the last 10 years gained a lot of attention within the research community. A wireless ad hoc network is a special type of wireless network where nodes are typically mobile and doesn’t rely on any fixed infrastructure to operate correctly. Much work has been done on developing robust and stable routing algorithms that consider the dynamic nature of an ad hoc network: n
Hereditary severe combined immunodeficiency (SCID) includes a heterogeneous group of diseases that profoundly affect both cellular and humoral immune responses and require treatment by bone marrow transplantation. Characterization of the cellular and molecular bases of SCID is essential to provide accurate genetic counseling and prenatal diagnosis, and it may offer the grounds for alternative form
OBJECTIVES: Neutrophils are activated and infiltrate the myocardium after ischemia and reperfusion. The involvement of neutrophils in irreversible reperfusion injury is suggested by numerous experimental studies. The aim of this study was to investigate markers of neutrophil activation following reperfusion of acute myocardial infarction (AMI) accomplished with percutaneous coronary intervention (
BACKGROUND. In recent studies serum levels of human glandular kallikrein 2 (hK2) demonstrated significant differences in pathologically organ-confined versus non-organ-confined prostate cancer (Pca). In this study we investigated whether hK2 adds independent information when considered together with traditionally used parameters to predict organ confined (pT2a/b) PCa. METHODS. Serum levels of hK2,
The paper discusses the modern metropolis as modernity in nucleo. Thereby it refers to notions like state of emergency, provisional realities, crisis, contingency, complexity. Recurrent references include Simmel, Blumenberg, Musil, Park.
Specific inhibition of the entry of encephalitogenic T lymphocytes into the central nervous system in multiple sclerosis would provide a means of inhibiting disease without compromising innate immune responses. We show here that targeting lymphocyte interactions with endothelial basement membrane laminins provides such a possibility. In mouse experimental autoimmune encephalomyelitis, T lymphocyte
OBJECTIVE: To compare the reliability of quantitative measurement of minimum hip joint space with a qualitative global assessment of radiological features for estimating the prevalence of primary osteoarthritis (OA) of the hip in colon radiographs.METHODS: All colon radiographs from patients aged 35 or older, taken at three different radiographic departments in Iceland during the years 1990-96, we
Popular Abstract in Swedish Denna avhandling beskriver studier av de mekanismer varmed bakterien Streptococcus pyogenes undviker komplementdeposition och fagocytos.Phagocytosis of Streptococcus pyogenes is complement dependent. However, the cell wall-associated M protein, which exists in >100 different serotypes (M types), enables the bacteria to evade phagocytosis. To analyze the mechanisms by which M protein confers this ability we used, as model systems, two representative M proteins, the M22 and M5 proteins, which have properties typical for many M prote
This paper describes how attribute grammars can be used to integrate program visualization in language-based environments and how program visualizations can be specified and generated from grammars. It is discussed how a general solution for a simple grammar can be reused in grammars for other specific languages. As an example we show how diagram generation for a very simple state transition langu
The interaction between the nonionic surfactant C12EO6 and the poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock copolymer EO20PO68EO20 (P123) has been investigated by means of isothermal titration and differential scanning calorimetry (DSC) as well as static and dynamic light scattering (SLS and DLS). P123 self-assembles in water into spherical micelles at ambient temperatu
Popular Abstract in Swedish Avhandlingen utgörs av en kritisk edition av Johannes Annorelius? latinska brev till brodern Julius (G3, Uppsala universitetsbibliotek). I början av 1700-talet lämnade Johannes Annorelius Uppsala och blev katolik och kapucinmunk i Flandern. Från klostret skrev han många, långa brev på franska och latin till sin lutherske bror i Sverige. I breven förklarar han varför hanThis book presents a critical edition of the Latin letters in ms. G3 (Uppsala University Library) from Johannes Annorelius to his brother. Johannes Annorelius left Sweden as a young student in the beginning of the 18th century and settled down in Flanders, where he converted to the Catholic faith and became a Capuchin friar. In the Capuchin friary Annorelius wrote several extensive letters in Fren
BACKGROUND: Information on cancer prevalence is of major importance for health planning and resource allocation. However, systematic information on cancer prevalence is largely unavailable. MATERIALS AND METHODS: Thirty-eight population-based cancer registries from 17 European countries, participating in EUROPREVAL, provided data on almost 3 million cancer patients diagnosed from 1970 to 1992. Sta
